Results 11 to 20 of about 17,995 (192)

Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages

open access: yesActa Pharmaceutica Sinica B, 2023
Myocardial dysfunction is the most serious complication of sepsis. Sepsis-induced myocardial dysfunction (SMD) is often associated with gastrointestinal dysfunction, but its pathophysiological significance remains unclear.
Dandong Fang   +17 more
doaj   +1 more source

Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome

open access: yesArchives of Medical Science, 2022
Introduction Cholecystokinin (CCK) is involved in several metabolic pathways, and CCK agonists are considered as a potential novel treatment option in populations with increased metabolic risk, including polycystic ovary syndrome (PCOS).
Eva Drnovsek   +6 more
doaj   +1 more source

Localization of the murine cholecystokinin A and B receptor genes [PDF]

open access: yesMammalian Genome, 1995
We have determined the chromosomal locations of the two cholecystokinin (CCK) receptor genes in the mouse. Genetic localization utilized an interspecific backcross panel formed from the cross (C57BL/6J x Mus spretus) F1 x Mus spretus. Genomic DNAs from 94 individuals in the backcross were analyzed by Southern hybridization with rat CCKA and CCKB ...
Isakoff, M. S.   +2 more
openaire   +3 more sources

Cholecystokinin Outcome on Markers of Intestinal IgA Antibody Response

open access: yesCurrent Issues in Molecular Biology, 2022
Cholecystokinin 8 (CCK8) is an entero-octapeptide that participates in crosstalk with components of intestinal immunity via the CCK receptor (CCKR), but its role in modulation of the IgA response is not fully known under physiological conditions.
Juan Morales-Magaña   +8 more
doaj   +1 more source

Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory

open access: yesFrontiers in Neuroanatomy, 2021
Telencephalic cognitive and emotional circuits/functions are strongly modulated by subcortical inputs. The main focus of past research on the nature of this modulation has been on the widespread monoamine projections to the telencephalon.
Isis Gil-Miravet   +8 more
doaj   +1 more source

Effects of γ-aminobutyric acid on feed intake, growth performance and expression of related genes in growing lambs

open access: yesAnimal, 2015
This study was conducted to investigate the effects of rumen-protected γ-aminobutyric acid (GABA) on feed intake, growth performance and expression of related genes in growing lambs.
D.M. Wang   +5 more
doaj   +1 more source

Transcriptome Sequencing Analysis of Sex-Related Genes in the Gonads of Mytilus unguiculatus

open access: yesFishes, 2023
In the cultivation of Mytilus unguiculatus, the broodstock are shade-dried to stimulate sperm and egg production. To identify the functional genes affecting gonad development in M.
Yanwen Ma   +4 more
doaj   +1 more source

Expression of the Cholecystokinin-B Receptor in Neoplastic Gastric Cells [PDF]

open access: yesHormones and Cancer, 2017
Gastric cancer is an important disease due to its high mortality. Despite the decline in frequency, most cases are discovered late in its course, and most of the cancer patients die within a few years of diagnosis. In addition to Helicobacter pylori gastritis, gastrin is considered an important factor in the development of this disease, and thus ...
Mjønes, Patricia   +6 more
openaire   +3 more sources

Heteromerization of μ-opioid receptor and cholecystokinin B receptor through the third transmembrane domain of the μ-opioid receptor contributes to the anti-opioid effects of cholecystokinin octapeptide

open access: yesExperimental and Molecular Medicine, 2018
Pain medicine: Boosting the potency of opioid analgesics A hormone known to weaken the pain-relieving effects of opioid drugs does so because of interaction between the hormone receptor and the opioid receptor.
Yin Yang   +5 more
doaj   +1 more source

Kidney Gastrin/CCKBR Attenuates Type 2 Diabetes Mellitus by Inhibiting SGLT2-Mediated Glucose Reabsorption through Erk/NF-κB Signaling Pathway [PDF]

open access: yesDiabetes & Metabolism Journal
Background Both sodium-glucose cotransporters (SGLTs) and Na+/H+ exchangers (NHEs) rely on a favorable Na-electrochemical gradient. Gastrin, through the cholecystokinin B receptor (CCKBR), can induce natriuresis and diuresis by inhibiting renal NHEs ...
Xue Zhang   +8 more
doaj   +1 more source

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