Results 31 to 40 of about 85,930 (259)

Olmesartan potentiates the anti-angiogenic effect of sorafenib in mice bearing Ehrlich's ascites carcinoma: role of angiotensin (1-7). [PDF]

PLoS ONE, 2014
Local renin-angiotensin systems exist in various malignant tumor tissues; this suggests that the main effector peptide, angiotensin II, could act as a key factor in tumor growth.
Mohammad M Abd-Alhaseeb, Sawsan A Zaitone, Soad H Abou-El-Ela, Yasser M Moustafa   +3 more
doaj   +1 more source

IGF-I and insulin activate mitogen-activated protein kinase via the type 1 IGF receptor in mouse embryonic stem cells [PDF]

Reproduction, 2007
Although IGF-I and insulin are important modulators of preimplantation embryonic physiology, the signalling pathways activated during development remain to be elucidated. As a model of preimplantation embryos, pluripotent mouse embryonic stem cells were used to investigate which receptor mediated actions of physiological concentrations of IGF-I and ...
Nguyen, T. T., Sheppard, A. M., Kaye, P. L., Noakes, P. G.   +3 more
openaire   +3 more sources

Identification of IGF-1-enhanced cytokine expressions targeted by miR-181d in glioblastomas via an integrative miRNA/mRNA regulatory network analysis

Scientific Reports, 2017
The insulin-like growth factor (IGF)-1 signaling is relevant in regulating cell growth and cytokine secretions by glioblastomas. MicroRNAs determine the cell fate in glioblastomas. However, relationships between IGF-1 signaling and miRNAs in glioblastoma
Kuo-Hao Ho, Peng-Hsu Chen, Edward Hsi, Chwen-Ming Shih, Wei-Chiao Chang, Chia-Hsiung Cheng, Cheng-Wei Lin, Ku-Chung Chen   +7 more
doaj   +1 more source

Differential Expression of IGF Components and Insulin Receptor Isoforms in Human Seminoma Versus Normal Testicular Tissue

Neoplasia: An International Journal for Oncology Research, 2005
Insulin-like growth factors (IGF) have mitogenic and antiapoptotic functions, and may be involved in tumor growth. The purpose of the study was to investigate the role of IGF components in seminoma compared to normal testis.
Tanja Pascale Neuvians, Isabella Gashaw, Andrea Hasenfus, Axel Häcker, Elke Winterhager, Rainer Grobholz   +5 more
doaj   +1 more source

Role of the Insulin-Like Growth Factor Type 1 Receptor in the Pathogenesis of Diabetic Encephalopathy

International Journal of Endocrinology, 2015
Defective cognitive function is common in patients with diabetes, suggesting that insulin normally exerts anabolic actions in neuron, namely, diabetic encephalopathy.
Duo Zhang, Shuang Jiang, Heng Meng
doaj   +1 more source

Insulin-like Growth Factor-Dependent Proliferation and Survival of Triple-Negative Breast Cancer Cells: Implications for Therapy

Neoplasia: An International Journal for Oncology Research, 2011
Triple-negative breast cancers have a poor prognosis and are not amenable to endocrine- or HER2-targeted therapies. The prevailing view is that targeting the insulin-like growth factor (IGF) signal transduction pathway will not be beneficial for triple ...
Zoë Davison, Gail E. de Blacquière, Bruce R. Westley, Felicity E.B. May   +3 more
doaj   +1 more source

Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cells. [PDF]

PLoS ONE, 2012
Type I insulin-like growth factor receptor (IGF-1R) and insulin receptor (INSR) are highly homologous molecules, which can heterodimerize to form an IGF-1R/INSR hybrid (Hybrid-R).
Yu-Chieh Wu, Meifang Zhu, Danielle M Robertson   +2 more
doaj   +1 more source

Type 1 Insulin-like Growth Factor Receptor (IGF-IR) Signaling Inhibits Apoptosis Signal-regulating Kinase 1 (ASK1) [PDF]

Journal of Biological Chemistry, 2003
The type 1 insulin-like growth factor receptor (IGF-IR) is a receptor-tyrosine kinase that plays a critical role in signaling cell survival and proliferation. IGF-IR binding to its ligand, insulin-like growth factor (IGF-I) activates phosphoinositide 3-kinase (PI3K), promotes cell proliferation by activating the mitogen-activated protein kinase (MAPK ...
Veronica, Galvan, Anna, Logvinova, Sabina, Sperandio, Hidenori, Ichijo, Dale E, Bredesen   +4 more
openaire   +2 more sources

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

Cell, 1993
Newborn mice homozygous for a targeted disruption of insulin-like growth factor gene (Igf-1) exhibit a growth deficiency similar in severity to that previously observed in viable Igf-2 null mutants (60% of normal birthweight). Depending on genetic background, some of the Igf-1(-/-) dwarfs die shortly after birth, while others survive and reach ...
J P, Liu, J, Baker, A S, Perkins, E J, Robertson, A, Efstratiadis   +4 more
openaire   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source