Results 1 to 10 of about 71,218 (134)

Stimulation of Human Extravillous Trophoblast Migration by IGF-II Is Mediated by IGF Type 2 Receptor Involving Inhibitory G Protein(s) and Phosphorylation of MAPK [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2001
We have earlier shown that migration and invasiveness of first trimester human extravillous trophoblast cells are stimulated by IGF-II, independently of IGF type 1 receptor and that migration stimulation is the primary reason for increased extravillous trophoblast cell invasiveness induced by IGF-II. In the present study we examined the functional role
Peeyush K. Lala, Peter Chidiac, Chandan Chakraborty, Louise M. Gleeson, Timothy McKinnon   +4 more
openaire   +3 more sources

Identification of a Resistance Mechanism to IGF-IR Targeting in Human Triple Negative MDA-MB-231 Breast Cancer Cells

Biomolecules, 2021
Triple negative breast cancer (TNBC) is associated with unfavorable prognosis and high relapse rates following chemotherapy. There is an urgent need to develop effective targeted therapy for this BC subtype. The type I insulin-like growth factor receptor
Jennifer Tsui, Shu Qi, Stephanie Perrino, Matthew Leibovitch, Pnina Brodt   +4 more
doaj   +1 more source

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes [PDF]

Genes & Development, 2001
Peripheral insulin resistance and impaired insulin action are the primary characteristics of type 2 diabetes. The first observable defect in this major disorder occurs in muscle, where glucose disposal in response to insulin is impaired. We have developed a transgenic mouse with a dominant-negative insulin-like growth factor-I receptor (KR–IGF-IR ...
Fernández, Ana M., Kim, Jason K., Yakar, Shoshana, Dupont, Joëlle, Hernandez-Sanchez, Catalina, Castle, Arthur L., Filmore, Jonathan, Shulman, Gerald I., Le Roith, Derek   +8 more
openaire   +6 more sources

The IGF/Insulin-IGFBP Axis in Corneal Development, Wound Healing, and Disease

Frontiers in Endocrinology, 2020
The insulin-like growth factor (IGF) family plays key roles in growth and development. In the cornea, IGF family members have been implicated in proliferation, differentiation, and migration, critical events that maintain a smooth refracting surface that
Whitney L. Stuard, Rossella Titone, Danielle M. Robertson   +2 more
doaj   +1 more source

Correlation of serum IGF-1, AGEs and their receptors with the risk of colorectal cancer in patients with type 2 diabetes mellitus

Frontiers in Oncology, 2023
BackgroundAccording to epidemiological evidence, people with type 2 diabetes mellitus have a higher risk of developing colorectal cancer.ObjectiveTo examine the relationship between colorectal cancer (CRC) and serum levels of IGF-1, IGF-1R, AGEs,RAGE and sRAGE in patients with type 2 diabetes.MethodsBy using RNA−Seq data of CRC patients from The Cancer
Zeng Chen, Qiao Hong
openaire   +3 more sources

The Soluble Type 2 Insulin-like Growth Factor (IGF-II) Receptor Reduces Organ Size by IGF-II-mediated and IGF-II-independent Mechanisms [PDF]

Journal of Biological Chemistry, 1998
The soluble type 2 insulin-like growth factor (IGF) receptor or IGF-II/mannose 6-phosphate receptor (sIGF2R) is produced in vivo by proteolytic deletion of the transmembrane and intracellular domains of the cellular form of the receptor (IGF2R). There is evidence that sIGF2R is a negative regulator of growth.
Sarah E. Squire, Silvio Zaina
openaire   +3 more sources

Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients. [PDF]

PLoS ONE, 2016
Insulin-like growth factor (IGF) signalling plays a key role in homing, progression, and treatment resistance in multiple myeloma (MM). In the extracellular environment, the majority of IGF molecules are bound to one of six IGF-binding proteins (IGFBP1-6)
Liesbeth Bieghs, Malene Brohus, Ida B Kristensen, Niels Abildgaard, Martin Bøgsted, Hans E Johnsen, Cheryl A Conover, Elke De Bruyne, Karin Vanderkerken, Michael T Overgaard, Mette Nyegaard   +10 more
doaj   +1 more source

The Role of Insulin and Insulin-like Growth Factors in the Increased Risk of Cancer in Diabetes

Rambam Maimonides Medical Journal, 2011
Patients with type 2 diabetes (T2D) are at increased risk of developing cancer. This evidence arises from numerous epidemiologic studies that relate a positive association between T2D and cancer. In-vitro and several in-vivo experiments have attempted to
Derek LeRoith, Eyal J. Scheinman, Keren Bitton-Worms   +2 more
doaj   +1 more source

The Continuing Evolution of Insulin-like Growth Factor Signaling [version 1; peer review: 4 approved]

F1000Research, 2020
The insulin-like growth factors (IGFs; IGF1/IGF2), known for their regulation of cell and organismal growth and development, are evolutionarily conserved ligands with equivalent peptides present in flies (D. melanogaster), worms (C. elegans) among others.
Steven A Rosenzweig
doaj   +1 more source

Differential Expression of IGF Components and Insulin Receptor Isoforms in Human Seminoma Versus Normal Testicular Tissue

Neoplasia: An International Journal for Oncology Research, 2005
Insulin-like growth factors (IGF) have mitogenic and antiapoptotic functions, and may be involved in tumor growth. The purpose of the study was to investigate the role of IGF components in seminoma compared to normal testis.
Tanja Pascale Neuvians, Isabella Gashaw, Andrea Hasenfus, Axel Häcker, Elke Winterhager, Rainer Grobholz   +5 more
doaj   +1 more source