Results 21 to 30 of about 158,687 (265)

Insulin-like growth factor-1 is a negative modulator of glucagon secretion [PDF]

, 2017
Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose.
Andreozzi, F, Di Fatta, C, Fuoco, A, Mancuso, E, Mannino, Gc, Sesti, G, Spiga, R   +6 more
core   +1 more source

Synergistic cardiac pathological hypertrophy induced by high-salt diet in IGF-IIRα cardiac-specific transgenic rats.

PLoS ONE, 2019
Stress-induced cardiac hypertrophy leads to heart failure. Our previous studies demonstrate that insulin-like growth factor-II receptor (IGF-IIR) signaling is pivotal to hypertrophy regulation.
Ruey-Lin Chang, Srinivasan Nithiyanantham, Chih-Yang Huang, Pei-Ying Pai, Tung-Ti Chang, Lai-Chin Hu, Ray-Jade Chen, V VijayaPadma, Wei-Wen Kuo, Chih-Yang Huang   +9 more
doaj   +1 more source

Insulin signaling regulates mitochondrial function in pancreatic beta-cells. [PDF]

PLoS ONE, 2009
Insulin/IGF-I signaling regulates the metabolism of most mammalian tissues including pancreatic islets. To dissect the mechanisms linking insulin signaling with mitochondrial function, we first identified a mitochondria-tethering complex in beta-cells ...
Siming Liu, Terumasa Okada, Anke Assmann, Jamie Soto, Chong Wee Liew, Heiko Bugger, Orian S Shirihai, E Dale Abel, Rohit N Kulkarni   +8 more
doaj   +1 more source

Olmesartan potentiates the anti-angiogenic effect of sorafenib in mice bearing Ehrlich's ascites carcinoma: role of angiotensin (1-7). [PDF]

PLoS ONE, 2014
Local renin-angiotensin systems exist in various malignant tumor tissues; this suggests that the main effector peptide, angiotensin II, could act as a key factor in tumor growth.
Mohammad M Abd-Alhaseeb, Sawsan A Zaitone, Soad H Abou-El-Ela, Yasser M Moustafa   +3 more
doaj   +1 more source

Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer.

PLoS ONE, 2016
Therapies targeting the type I insulin-like growth factor receptor (IGF-1R) have not been developed with predictive biomarkers to identify tumors with receptor activation.
Marc A Becker, Yasir H Ibrahim, Annabell S Oh, Dedra H Fagan, Sara A Byron, Aaron L Sarver, Adrian V Lee, Leslie M Shaw, Cheng Fan, Charles M Perou, Douglas Yee   +10 more
doaj   +1 more source

Insulin-like growth factor-I gene delivery to astrocytes reduces their inflammatory response to lipopolysaccharide

Journal of Neuroinflammation, 2011
Background Insulin-like growth factor-I (IGF-I) exerts neuroprotective actions in the central nervous system that are mediated at least in part by control of activation of astrocytes. In this study we have assessed the efficacy of exogenous IGF-I and IGF-
Goya Rodolfo G, Hereñú Claudia B, Bellini Maria J, Garcia-Segura Luis M   +3 more
doaj   +1 more source

Angiotensin II receptor blocker attenuates intrarenal renin-angiotensin-system and podocyte injury in rats with myocardial infarction. [PDF]

PLoS ONE, 2013
The mechanisms and mediators underlying common renal impairment after myocardial infarction (MI) are still poorly understood. The present study aimed to test the hypothesis that angiotensin II type 1 receptor blockers (ARBs) provides renoprotective ...
Zhu-zhi Wen, Mu-yan Cai, Zun Mai, Dong-mei Jin, Yang-xin Chen, Hui Huang, Deng-feng Geng, Jing-feng Wang   +7 more
doaj   +1 more source

Fluorescent-Antibody Targeting of Insulin-Like Growth Factor-1 Receptor Visualizes Metastatic Human Colon Cancer in Orthotopic Mouse Models. [PDF]

, 2016
Fluorescent-antibody targeting of metastatic cancer has been demonstrated by our laboratory to enable tumor visualization and effective fluorescence-guided surgery.
Bouvet, Michael, Hoffman, Robert M, Lee, Jin Young, Murakami, Takashi, Park, Jeong Youp, Zhang, Yong   +5 more
core   +2 more sources

Small interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer model.

PLoS ONE, 2012
Insulin-like growth factor I (IGF-I) and its type I receptor (IGF-IR) play significant roles in tumorigenesis and in immune response. Here, we wanted to know whether an RNA interference approach targeted to IGF-IR could be used for specific antitumor ...
Tiphanie Durfort, Mercedes Tkach, Mariya I Meschaninova, Martín A Rivas, Patricia V Elizalde, Alya G Venyaminova, Roxana Schillaci, Jean-Christophe François   +7 more
doaj   +1 more source

Germline PTPRD mutations in Ewing sarcoma: biologic and clinical implications. [PDF]

, 2013
Ewing sarcoma occurs in children, adolescents and young adults. High STAT3 levels have been reported in approximately 50% of patients with Ewing sarcoma, and may be important in tumorigenesis.
Anderson, Peter M, Angelo, Laura S, Benjamin, Robert S, Fu, Siqing, Herzog, Cynthia E, Janku, Filip, Jiang, Yunyun, Kurzrock, Razelle, Naing, Aung, Subbiah, Vivek   +9 more
core   +3 more sources