Results 21 to 30 of about 71,317 (233)

Insulin signaling regulates mitochondrial function in pancreatic beta-cells. [PDF]

PLoS ONE, 2009
Insulin/IGF-I signaling regulates the metabolism of most mammalian tissues including pancreatic islets. To dissect the mechanisms linking insulin signaling with mitochondrial function, we first identified a mitochondria-tethering complex in beta-cells ...
Siming Liu, Terumasa Okada, Anke Assmann, Jamie Soto, Chong Wee Liew, Heiko Bugger, Orian S Shirihai, E Dale Abel, Rohit N Kulkarni   +8 more
doaj   +1 more source

Purification of the Insulin-like growth factor II (IGF-II) receptor from an IGF-II-producing cell line, and generation of an antibody which both immunoprecipitates and blocks the type 2 IGF receptor

Biochemical and Biophysical Research Communications, 1986
18,54-SF cells, which secrete rat insulin-like growth factor II (rIGF-II), have abundant type 2 IGF receptors. We have purified the type 2 receptor from these cells by solubilization of crude membranes in Triton X-100, followed by chromatography on agarose-immobilized rIGF-II.
Hung Pham, D. Hodges, Phillip D.K. Lee, Ron G. Rosenfeld, David R. Powell   +4 more
openaire   +3 more sources

The ACAA-insertion/deletion polymorphism at the 3′ UTR of the IGF-II receptor gene is associated with type 2 diabetes and surrogate markers of insulin resistance [PDF]

European Journal of Endocrinology, 2006
Objective: The IGF-II receptor gene (IGFIIR) is located at chromosome 6q26, a region that harbors a genetic marker linked to insulin-resistant traits in Mexican–Americans. In the present study conducted in Spaniards, we tested a common polymorphism in IGFIIR for association with type 2 diabetes and insulin-resistant traits.
Wifredo Ricart, Gemma Villuendas, Abel López-Bermejo, José Manuel Fernández-Real, José L. San Millán, Carme Gubern, José I. Botella-Carretero, Héctor F. Escobar-Morreale   +7 more
openaire   +2 more sources

Synergistic cardiac pathological hypertrophy induced by high-salt diet in IGF-IIRα cardiac-specific transgenic rats.

PLoS ONE, 2019
Stress-induced cardiac hypertrophy leads to heart failure. Our previous studies demonstrate that insulin-like growth factor-II receptor (IGF-IIR) signaling is pivotal to hypertrophy regulation.
Ruey-Lin Chang, Srinivasan Nithiyanantham, Chih-Yang Huang, Pei-Ying Pai, Tung-Ti Chang, Lai-Chin Hu, Ray-Jade Chen, V VijayaPadma, Wei-Wen Kuo, Chih-Yang Huang   +9 more
doaj   +1 more source

Olmesartan potentiates the anti-angiogenic effect of sorafenib in mice bearing Ehrlich's ascites carcinoma: role of angiotensin (1-7). [PDF]

PLoS ONE, 2014
Local renin-angiotensin systems exist in various malignant tumor tissues; this suggests that the main effector peptide, angiotensin II, could act as a key factor in tumor growth.
Mohammad M Abd-Alhaseeb, Sawsan A Zaitone, Soad H Abou-El-Ela, Yasser M Moustafa   +3 more
doaj   +1 more source

Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer.

PLoS ONE, 2016
Therapies targeting the type I insulin-like growth factor receptor (IGF-1R) have not been developed with predictive biomarkers to identify tumors with receptor activation.
Marc A Becker, Yasir H Ibrahim, Annabell S Oh, Dedra H Fagan, Sara A Byron, Aaron L Sarver, Adrian V Lee, Leslie M Shaw, Cheng Fan, Charles M Perou, Douglas Yee   +10 more
doaj   +1 more source

ErbB2 enhances mammary tumorigenesis, oncogene-independent recurrence and metastasis in a model of IGF-IR-mediated mammary tumorigenesis

Molecular Cancer, 2010
Background The type I insulin-like growth factor receptor (IGF-IR) and ErbB2 (Her-2) are receptor tyrosine kinases implicated in human breast cancer.
Campbell Craig I, Petrik James J, Moorehead Roger A   +2 more
doaj   +1 more source

Angiotensin II receptor blocker attenuates intrarenal renin-angiotensin-system and podocyte injury in rats with myocardial infarction. [PDF]

PLoS ONE, 2013
The mechanisms and mediators underlying common renal impairment after myocardial infarction (MI) are still poorly understood. The present study aimed to test the hypothesis that angiotensin II type 1 receptor blockers (ARBs) provides renoprotective ...
Zhu-zhi Wen, Mu-yan Cai, Zun Mai, Dong-mei Jin, Yang-xin Chen, Hui Huang, Deng-feng Geng, Jing-feng Wang   +7 more
doaj   +1 more source

Analysis of insulin-like growth factors (IGF)-I, and -II, type II IGF receptor and IGF-binding protein-2 mRNA and peptide levels in normal and nephrectomized rat kidney

Kidney International, 1995
Immunocytochemistry, in situ hybridization, and radioimmunoassay were employed to examine the cellular distribution of mRNAs and proteins for IGF-I, II, IGF-II/M6P receptor, IGFBP2 as well as the levels of IGF-I and II in normal and unilaterally nephrectomized (Nx) adult rat kidneys.
Patricia B. Summerlin, Andrew P. Evan, Bret A. Connors, David P. Henry, Wei Hua Lee   +4 more
openaire   +3 more sources

Insulin-like growth factor-I gene delivery to astrocytes reduces their inflammatory response to lipopolysaccharide

Journal of Neuroinflammation, 2011
Background Insulin-like growth factor-I (IGF-I) exerts neuroprotective actions in the central nervous system that are mediated at least in part by control of activation of astrocytes. In this study we have assessed the efficacy of exogenous IGF-I and IGF-
Goya Rodolfo G, Hereñú Claudia B, Bellini Maria J, Garcia-Segura Luis M   +3 more
doaj   +1 more source