Results 21 to 30 of about 329,666 (334)

Differential Expression of IGF Components and Insulin Receptor Isoforms in Human Seminoma Versus Normal Testicular Tissue

Neoplasia: An International Journal for Oncology Research, 2005
Insulin-like growth factors (IGF) have mitogenic and antiapoptotic functions, and may be involved in tumor growth. The purpose of the study was to investigate the role of IGF components in seminoma compared to normal testis.
Tanja Pascale Neuvians, Isabella Gashaw, Andrea Hasenfus, Axel Häcker, Elke Winterhager, Rainer Grobholz   +5 more
doaj   +1 more source

Ovarian follicular expression of mRNA encoding the type I IGF receptor and IGF-binding protein-2 in sheep following five days of nutritional supplementation with glucose, glucosamine or lupins [PDF]

Reproduction, 2004
The IGF system is associated with ovarian folliculogenesis. The effect of the IGFs mediated through the type I receptor (IGF-IR) and IGF-binding protein-2 (IGFBP-2), is to regulate the growth and atresia of follicles. To test if the mRNAs for IGF-IR and IGFBP-2 are differentially regulated in the follicle we used nutritional treatments that stimulate ...
Dominique Blache, Graeme Martin, Rex J. Scaramuzzi, M. Munoz-Gutierrez   +3 more
openaire   +2 more sources

Inflammatory responses in primary muscle cell cultures in Atlantic salmon (Salmo salar) [PDF]

, 2013
Peer reviewedPublisher ...
Martin, Samuel A.M., Pooley, Nicholas J., Secombes, Christopher J., Tacchi, Luca   +3 more
core   +2 more sources

Reversal of age-related learning deficiency by the vertebrate PACAP and IGF-1 in a novel invertebrate model of aging: the pond snail (Lymnaea Stagnalis) [PDF]

, 2014
With the increase of life span, nonpathological age-related memory decline is affecting an increasing number of people. However, there is evidence that age-associated memory impairment only suspends, rather than irreversibly extinguishes, the intrinsic ...
Alexander, Audesirk, Chaudhury, D. Regl di, Delcourt, Du, G. Kemenes, Hattiangady, Hermann, Hernadi, I. Kemenes, J  zsa, Kemenes, Kemenes, Lee, Markowska, Otto, Otto, Patel, Patel, Pavlopoulos, Pirger, Pirger, Pirger, Roberto, S. Naskar, Sacchetti, Shioda, Silhol, Tamas, Telegdy, Vaudry, Watson, Watson, Yang, Yeoman, Z. Laszlo, Z. Pirger, Zhang   +38 more
core   +2 more sources

Structural Analogs of Human Insulin-like Growth Factor (IGF) I with Altered Affinity for Type 2 IGF Receptors

Journal of Biological Chemistry, 1989
We have used site-directed mutagenesis of a synthetic gene for insulin-like growth factor (IGF) I to prepare three analogs in which specific residues in the A region are replaced with the corresponding residues in the A chain of insulin. The analogs are [Ile41, Glu45, Gln46, Thr49, Ser50, Ile51, Ser53, Tyr55, Gln56]IGF I (A chain mutant), in which ...
Joy D Applebaum, Margaret A. Cascieri, B G Green, Gary G. Chicchi, Marvin L. Bayne, Nancy S. Hayes   +5 more
openaire   +3 more sources

The cellular repressor of E1A-stimulated genes mediates glucocorticoid-induced loss of the type-2 IGF receptor in ileal epithelial cells [PDF]

Journal of Endocrinology, 2005
Glucocorticoids induce hypertrophy of the neonatal ileal mucosa but the molecular mechanisms behind this growth induction remain poorly understood. Ileal epithelial cells (IECs) are dependent upon IGF-II for proliferation both in vivo and in culture. The type-2 IGF receptor (IGFR-2) is a lysosomal transport protein that attenuates IGF-II-driven growth ...
J B Paxton, Phillip V. Gordon, N S Fox
openaire   +2 more sources

The tobacco-specific carcinogen NNK induces pulmonary tumorigenesis via nAChR/Src/STAT3-mediated activation of the renin-angiotensin system and IGF-1R signaling

Experimental and Molecular Medicine, 2023
The renin-angiotensin (RA) system has been implicated in lung tumorigenesis without detailed mechanistic elucidation. Here, we demonstrate that exposure to the representative tobacco-specific carcinogen nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1 ...
Hye-Jin Boo, Hye-Young Min, Su Jung Hwang, Hyo-Jong Lee, Jae-Won Lee, Sei-Ryang Oh, Choon-Sik Park, Jong-Sook Park, You Mie Lee, Ho-Young Lee   +9 more
doaj   +1 more source

Elevated insulin-like growth factor (IGF) binding protein (IGFBP)-2 and IGFBP-4 expression of leukemic T-cells is affected by autocrine/paracrine IGF-II action but not by IGF type I receptor expression [PDF]

European Journal of Endocrinology, 1998
We recently found evidence indicating that the source of elevated serum insulin-like growth factor binding protein (IGFBP)-2 in leukemia was the leukemic T-cells. Here we report that locally produced IGF-II affects IGFBP-2 expression and growth of leukemic cells through the IGF type I receptor.
Bell M, Sanatani Ms, Martin W. Elmlinger, Michael B. Ranke, Dannecker Ge   +4 more
openaire   +3 more sources

Insulin-like growth factor-1 is a negative modulator of glucagon secretion [PDF]

, 2017
Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose.
Andreozzi, F, Di Fatta, C, Fuoco, A, Mancuso, E, Mannino, Gc, Sesti, G, Spiga, R   +6 more
core   +1 more source

Fluorescent-Antibody Targeting of Insulin-Like Growth Factor-1 Receptor Visualizes Metastatic Human Colon Cancer in Orthotopic Mouse Models. [PDF]

, 2016
Fluorescent-antibody targeting of metastatic cancer has been demonstrated by our laboratory to enable tumor visualization and effective fluorescence-guided surgery.
Bouvet, Michael, Hoffman, Robert M, Lee, Jin Young, Murakami, Takashi, Park, Jeong Youp, Zhang, Yong   +5 more
core   +2 more sources