Results 31 to 40 of about 158,687 (265)
Molecular Cancer, 2010 Background The type I insulin-like growth factor receptor (IGF-IR) and ErbB2 (Her-2) are receptor tyrosine kinases implicated in human breast cancer.
Campbell Craig I +2 more
doaj +1 more source
Poultry Science, 2023 : The insulin-like growth factor (IGF) system plays an indispensable role in embryonic and postnatal development in mammals. However, the effects of the system on growth, carcass, and egg-laying traits, and diversified selection have not been ...
Yulong Guo +13 more
doaj +1 more source
Cellular and molecular mediators of bone metastatic lesions [PDF]
, 2018 Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia +3 more
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Androgen receptor overexpression in prostate cancer in type 2 diabetes
Molecular Metabolism, 2018 Objective: While prostate cancer does not occur more often in men with diabetes, survival is markedly reduced in this patient group. Androgen signaling is a known and major driver for prostate cancer progression.
Stefan Zoltán Lutz +17 more
doaj +1 more source
TRPV2 is critical for the maintenance of cardiac structure and function in mice [PDF]
, 2014 The heart has a dynamic compensatory mechanism for haemodynamic stress. However, the molecular details of how mechanical forces are transduced in the heart are unclear.
Iwasaki, Keiichiro +10 more
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IGF-1 protects against angiotensin II-induced cardiac fibrosis by targeting αSMA
Cell Death and Disease, 2021 The insulin-like growth factor 1 receptor (IGF-1R) signaling in cardiomyocytes is implicated in physiological hypertrophy and myocardial aging. Although fibroblasts account for a small amount of the heart, they are activated when the heart is damaged to ...
Sangmi Ock +5 more
doaj +1 more source
Leptin receptor in the chicken ovary: potential involvement in ovarian dysfunction of ad libitum-fed broiler breeder hens [PDF]
, 2004 In hens, the ovarian follicles committed to ovulation are arranged in an ordered follicular hierarchy. In standard broiler breeders hens genetically selected for high growth rate the reproductive function is clearly dysfunctional.
Cassy, Sandrine +5 more
core +3 more sources
Respiratory Research, 2005 Background Cellular responses to aging and oxidative stress are regulated by type 1 insulin-like growth factor receptor (IGF-1R). Oxidant injury, which is implicated in the pathophysiology of a number of respiratory diseases, acutely upregulates IGF-1R ...
Flejou Jean-François +7 more
doaj +1 more source
Understanding the key to targeting the IGF axis in cancer: a biomarker assessment
Frontiers in Oncology, 2015 Type 1 insulin like growth factor receptor (IGF-1R) targeted therapies showed compelling pre-clinical evidence; however, to date, this failed to translate to patient benefit in Phase 2/3 trails in unselected patients. This was further complicated by the
Kunal Amratlal Lodhia +2 more
doaj +1 more source
Mammalian models of extended healthy lifespan [PDF]
, 2011 Over the last two centuries, there has been a significant increase in average lifespan expectancy in the developed world. One unambiguous clinical implication of getting older is the risk of experiencing age-related diseases including various cancers ...
Colin Selman +7 more
core +2 more sources