Results 41 to 50 of about 329,666 (334)

Angiotensin II receptor blocker attenuates intrarenal renin-angiotensin-system and podocyte injury in rats with myocardial infarction. [PDF]

PLoS ONE, 2013
The mechanisms and mediators underlying common renal impairment after myocardial infarction (MI) are still poorly understood. The present study aimed to test the hypothesis that angiotensin II type 1 receptor blockers (ARBs) provides renoprotective ...
Zhu-zhi Wen, Mu-yan Cai, Zun Mai, Dong-mei Jin, Yang-xin Chen, Hui Huang, Deng-feng Geng, Jing-feng Wang   +7 more
doaj   +1 more source

Exploring metabolic dysfunction in chronic kidney disease [PDF]

, 2012
Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and end-stage renal disease (ESRD) is a serious medical condition associated with increased morbidity, mortality, and in particular cardiovascular disease (CVD) risk ...
Slee, Adrian D.
core   +2 more sources

Insulin-like growth factor-I gene delivery to astrocytes reduces their inflammatory response to lipopolysaccharide

Journal of Neuroinflammation, 2011
Background Insulin-like growth factor-I (IGF-I) exerts neuroprotective actions in the central nervous system that are mediated at least in part by control of activation of astrocytes. In this study we have assessed the efficacy of exogenous IGF-I and IGF-
Goya Rodolfo G, Hereñú Claudia B, Bellini Maria J, Garcia-Segura Luis M   +3 more
doaj   +1 more source

Analysis of insulin-like growth factors (IGF)-I, and -II, type II IGF receptor and IGF-binding protein-2 mRNA and peptide levels in normal and nephrectomized rat kidney

Kidney International, 1995
Immunocytochemistry, in situ hybridization, and radioimmunoassay were employed to examine the cellular distribution of mRNAs and proteins for IGF-I, II, IGF-II/M6P receptor, IGFBP2 as well as the levels of IGF-I and II in normal and unilaterally nephrectomized (Nx) adult rat kidneys.
Patricia B. Summerlin, Andrew P. Evan, Bret A. Connors, David P. Henry, Wei Hua Lee   +4 more
openaire   +3 more sources

Prospective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab [PDF]

, 2015
Background: The aim of our study was to evaluate whether a panel of biomarkers, prospectively analysed might be able to predict patients' clinical outcome more accurately than RAS status alone.
Abouelkhair, KM, Cascinu, S, Del Prete, M, Faloppi, L, Giampieri, R, Ibrahim, EM, Loretelli, C, Mandolesi, A, Maristella, B, Scarpelli, M, Scartozzi, M   +10 more
core   +3 more sources

Activation of the S100A7/RAGE Pathway by IGF-1 Contributes to Angiogenesis in Breast Cancer

Cancers, 2021
Simple Summary Breast cancer mortality is increased in patients affected by metabolic disorders associated with dysregulation of the Insulin-like growth factor-1 (IGF-1) axis, like obesity and type-2 diabetes.
M. G. Muoio, M. Talia, R. Lappano, Andrew H Sims, V. Vella, F. Cirillo, Livia Manzella, M. Giuliano, M. Maggiolini, A. Belfiore, E. M. De Francesco   +10 more
semanticscholar   +1 more source

ErbB2 enhances mammary tumorigenesis, oncogene-independent recurrence and metastasis in a model of IGF-IR-mediated mammary tumorigenesis

Molecular Cancer, 2010
Background The type I insulin-like growth factor receptor (IGF-IR) and ErbB2 (Her-2) are receptor tyrosine kinases implicated in human breast cancer.
Campbell Craig I, Petrik James J, Moorehead Roger A   +2 more
doaj   +1 more source

Decreased IGF Type 1 Receptor Signaling in Mammary Epithelium during Pregnancy Leads to Reduced Proliferation, Alveolar Differentiation, and Expression of Insulin Receptor Substrate (IRS)-1 and IRS-2 [PDF]

Endocrinology, 2011
The IGFs and the IGF type 1 receptor (IGF-1R) are essential mediators of normal mammary gland development in mice. IGF-I and the IGF-1R have demonstrated functions in formation and proliferation of terminal end buds and in ductal outgrowth and branching during puberty.
Zhaoyu Sun, Sain Shushanov, Derek LeRoith, Teresa L. Wood   +3 more
openaire   +2 more sources

Down-regulation of hepatic expression of GHR/STAT5/IGF-1 signaling pathway fosters development and aggressiveness of HCV-related hepatocellular carcinoma: Crosstalk with Snail-1 and type 2 transforming growth factor-beta receptor

PLOS ONE, 2022
Background and aims So far, few clinical trials are available concerning the role of growth hormone receptor (GHR)/signal transducer and activator of transcription 5 (STAT5)/insulin like growth factor-1 (IGF-1) axis in hepatocarcinogenesis. The aim of this study was to evaluate the hepatic expression of GHR/STAT5/IGF-1 signaling pathway in ...
Mona A. Abu El-Makarem, Mariana F. Kamel, Ahmed Abdelhaleem Mohamed, Hossam El‐Sheikh Ali, Mohamed Mahgoub, Alaa El-Deen M. Mohamed, Ahmed M. El-Said, Mahmoud G. Ameen, Alshymaa A. Hassnine, Hatem A. Hassan   +9 more
openaire   +2 more sources

Small interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer model.

PLoS ONE, 2012
Insulin-like growth factor I (IGF-I) and its type I receptor (IGF-IR) play significant roles in tumorigenesis and in immune response. Here, we wanted to know whether an RNA interference approach targeted to IGF-IR could be used for specific antitumor ...
Tiphanie Durfort, Mercedes Tkach, Mariya I Meschaninova, Martín A Rivas, Patricia V Elizalde, Alya G Venyaminova, Roxana Schillaci, Jean-Christophe François   +7 more
doaj   +1 more source