Results 51 to 60 of about 329,666 (334)
Poultry Science, 2023 : The insulin-like growth factor (IGF) system plays an indispensable role in embryonic and postnatal development in mammals. However, the effects of the system on growth, carcass, and egg-laying traits, and diversified selection have not been ...
Yulong Guo +13 more
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Estradiol, Progesterone, and Transforming Growth Factor α Regulate Insulin-Like Growth Factor Binding Protein-3 (IGFBP3) Expression in Mouse Endometrial Cells [PDF]
, 2009 Insulin-like growth factor 1 (IGF1) Is Involved in the proliferation of mouse and rat endometrial cells in a paracrine or autocrine manner. Insulin-like growth factor binding protein-3 (IGFBP3) modulates actions of IGFs directly or indirectly.
Hembree JR +10 more
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Androgen receptor overexpression in prostate cancer in type 2 diabetes
Molecular Metabolism, 2018 Objective: While prostate cancer does not occur more often in men with diabetes, survival is markedly reduced in this patient group. Androgen signaling is a known and major driver for prostate cancer progression.
Stefan Zoltán Lutz +17 more
doaj +1 more source
TRPV2 is critical for the maintenance of cardiac structure and function in mice [PDF]
, 2014 The heart has a dynamic compensatory mechanism for haemodynamic stress. However, the molecular details of how mechanical forces are transduced in the heart are unclear.
Iwasaki, Keiichiro +10 more
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IGF-1 protects against angiotensin II-induced cardiac fibrosis by targeting αSMA
Cell Death and Disease, 2021 The insulin-like growth factor 1 receptor (IGF-1R) signaling in cardiomyocytes is implicated in physiological hypertrophy and myocardial aging. Although fibroblasts account for a small amount of the heart, they are activated when the heart is damaged to ...
Sangmi Ock +5 more
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Cardiovascular Research, 2015 Aims Patients with conditions that are associated with insulin resistance such as obesity, type 2 diabetes mellitus, and polycystic ovary syndrome have an increased risk of thrombosis and a concurrent hyperactive platelet phenotype.
S. Moore +7 more
semanticscholar +1 more source
IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells [PDF]
, 2012 The cysteine-type peptidase cathepsin X is highly upregulated in several cancers and presumably promotes tumor invasion through bypassing cellular senescence. Here, we present first evidence that the underlying mechanism may involve the regulation of the
Bunsen, Thea +3 more
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Respiratory Research, 2005 Background Cellular responses to aging and oxidative stress are regulated by type 1 insulin-like growth factor receptor (IGF-1R). Oxidant injury, which is implicated in the pathophysiology of a number of respiratory diseases, acutely upregulates IGF-1R ...
Flejou Jean-François +7 more
doaj +1 more source
Cell-based gene therapy for mending infarcted hearts [PDF]
, 2011 The goal of this study was to analyse the efficiency of a combinatorial cell/growth factor therapy to improve function of infarcted murine hearts. The Insulin-like Growth Factor-1 (IGF-1) isoform, IGF-1Ea, has been shown to reduce scar formation and ...
Poudel, Bhawana, Poudel, Bhawana
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Understanding the key to targeting the IGF axis in cancer: a biomarker assessment
Frontiers in Oncology, 2015 Type 1 insulin like growth factor receptor (IGF-1R) targeted therapies showed compelling pre-clinical evidence; however, to date, this failed to translate to patient benefit in Phase 2/3 trails in unselected patients. This was further complicated by the
Kunal Amratlal Lodhia +2 more
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