Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway
Advanced Science, EarlyView.Viridicatol (VDC), isolated from the deep‐sea‐derived fungus, enhances osteogenesis in vitro and in vivo by targeting Wnt/SHN3 signaling pathway. It can be delivered via engineered nanovesicles to mitigate bone loss of osteoporosis, fracture repair, and osteogenesis imperfecta.
Chun‐Lan Xie +10 more
wiley +1 more source
Hormonal Crossroads in Inborn Errors of the Metabolism Impact of Puberty and Dietary Interventions on Metabolic Health. [PDF]
MetabolitesLundqvist T, Stenlid R, Halldin M.
europepmc +1 more source
Decoding Blastocystis‐Driven Mechanisms in Gut Microbiota and Host Metabolism
Advanced Science, EarlyView.Blastocystis, a prevalent gut microbe, interacts with the host through metabolic and immune pathways, influencing cardiometabolic health. This perspective explores its role in modulating short‐chain fatty acid production, tryptophan metabolism, and immune signaling, potentially impacting cholesterol absorption, glucose metabolism, and vascular health ...
Lei Deng, Kevin SW Tan
wiley +1 more source
Association of serum cortisol with insulin secretion and plasma aldosterone with insulin resistance in untreated type 2 diabetes: a cross-sectional study. [PDF]
Diabetol Metab SyndrOhira M +5 more
europepmc +1 more source
MTCH2 Suppresses Thermogenesis by Regulating Autophagy in Adipose Tissue
Advanced Science, EarlyView.This study demonstrates that MTCH2 acts as an evolutionarily conserved regulator of energy homeostasis across Drosophila, rodents, and humans. Adipose‐specific MTCH2 ablation enhances brown/beige adipose thermogenesis through Bcl‐2‐dependent autophagy, promoting energy expenditure and counteracting obesity‐associated metabolic disorders. These findings
Xin‐Yuan Zhao +17 more
wiley +1 more source
The effect of garlic and stevia extract with aerobic exercise on hypothalamic leptin and ghrelin receptor mRNA expression and insulin resistance in obese rats. [PDF]
BMC Complement Med TherAmirkhani Z +6 more
europepmc +1 more source
Advanced Science, EarlyView.The genome of Megachile rotundata, an extensively managed solitary pollination bee species, has been sequenced, covering 280.68 Mb and predicting 10 701 genes. The study reveals significant expansions of the Toll gene family and their abundant expression in diapause prepupae, highlighting enhanced immune responses during diapause. This genome serves as
Rangjun Shi +8 more
wiley +1 more source
Scaffold-free endocrine tissue engineering: role of islet organization and implications in type 1 diabetes. [PDF]
BMC Endocr DisordBal T.
europepmc +1 more source
Advanced Science, EarlyView.The impact of topography on the secretome of adipose‐derived stem cells (ADSCs) has the potential for promoting tendon regeneration. The secretome generated from ADSCs on aligned structure has a potent effect in promoting cell migration, proliferation, tenogenic differentiation, macrophage M2 polarization, and tendon mechanical function recovery ...
Qiuzi Long +14 more
wiley +1 more source
Insulin autoimmune syndrome in a patient with vitiligo: a case report and review of literature. [PDF]
J Med Case RepHeydari I +3 more
europepmc +1 more source