Results 251 to 260 of about 681,804 (310)

Rational Design and Organoid‐Based Evaluation of a Cocktail CAR‐γδ T Cell Therapy for Heterogeneous Glioblastoma

Advanced Science, EarlyView.
A novel “prof” cocktail therapy is designed. It screens antigens, selects personalized antigen panels, engineers optimized CAR‐Vδ1 T cells, and tests in patient‐derived GBM organoids, offering hope for effective CAR‐T drugs against heterogeneous solid tumors. Abstract Various challenges, including tumor heterogeneity and inadequate T cell infiltration,
Guidong Zhu, Zhongzheng Sun, Yingchao Liu, Jiang Liu, Linpei Guo, Guojing Pei, Ying Jiang, Baowang Miao, Zhen Li, Ping Zhang, Dongqi Tang, Wen Zhang, Chengwei Wang   +12 more
wiley   +1 more source

Section 9: Pharmacologic Approaches to Glycemic Treatment. [PDF]

Clin Diabetes
europepmc   +1 more source

Rabson-Mendenhall syndrome presented as severe acanthosis nigricans in an infant harboring novel mutations in the INSR gene: a case report. [PDF]

Front Pediatr
Yan S, Sheng Y, Hui HZ, Zhou CY, Liu DM.
europepmc   +1 more source

EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation

Advanced Science, EarlyView.
Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi, Ping Yang, Huaijin Qiao, Jinchen He, Bin Song, Hao Bai, Fengdi Jiang, Yining Zhang, Qian Li, Tao Yan, Wenlin Tu, Daojiang Yu, Shuyu Zhang   +12 more
wiley   +1 more source

A comprehensive review on the implications of Yogic/Sattvic diet in reducing inflammation in type 2 diabetes. [PDF]

Nutr Diabetes
Vallazhath A, Thimmappa PY, Joshi HB, Hebbar KR, Nayak A, Umakanth S, Saoji AA, Manjunath NK, Hadapad BS, Joshi MB.   +9 more
europepmc   +1 more source

A Touch Enabled Hemodynamic and Metabolic Monitor

Advanced Science, EarlyView.
This work presents a touch‐based hybrid platform for simultaneous monitoring of vital signs and sweat metabolites. With a simple tri‐finger touch of 4–6 min, users can concurrently get to know their glucose, uric acid, cortisol levels from fingertip sweat, along with blood pressure and heart rate.
Omeed Djassemi, Tamoghna Saha, Ponnusamy Nandhakumar, Muhammad Inam Khan, Hannah Fishman, Sara Earney, Chochanon Moonla, Yuchen Xu, Henry Thai, Sofia Morales‐Fermin, Gyeongho Kim, Rhea Park, Beya Acot, Oscar Wu, Cannon Wurster, An‐Yi Chang, Christopher Cheung, Julia Silberman, Shichao Ding, Joseph Wang   +19 more
wiley   +1 more source

Activation of the Insulin Receptor by <i>Sarcopoterium spinosum</i> Extract and Identification of Sarcocyanidin A as a Novel Active Compound. [PDF]

ACS Omega
Wollman A, Hasib Afana R, Carmeli S, Rosenzweig T.   +3 more
europepmc   +1 more source

INSULIN RECEPTOR TRAFFICKING

, 2010
Carpentier, Jean-Louis, Hamer, Isabelle, Foti, Michelangelo   +2 more
openaire   +2 more sources

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis

Advanced Science, EarlyView.
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu, Jiewen Liao, Chao Xu, Yuan Xiong, Juan Zhou, Guangji Wang, Ze Lin, Kangkang Zha, Chuanlu Lin, Ruiyin Zeng, Guandong Dai, Qian Feng, Bobin Mi, Guohui Liu   +13 more
wiley   +1 more source

Mechanistic Insights Into <i>Ganoderma Lucidum</i> for Diabetes Treatment via Network Pharmacology and Validation. [PDF]

Diabetes Metab Syndr Obes
Guo S, Yang L, Zhou J, Luo W, Nie B, Zhong X, Liu D, Kang X.   +7 more
europepmc   +1 more source