Results 31 to 40 of about 378,083 (173)
Security, extensibility, and redundancy in the Metabolic Operating System [PDF]
arXiv, 2023 People living with Type 1 Diabetes (T1D) lose the ability to produce insulin naturally. To compensate, they inject synthetic insulin. One common way to inject insulin is through automated insulin delivery systems, which use sensors to monitor their metabolic state and an insulin pump device to adjust insulin to adapt.
arxiv
Frontiers in Endocrinology, 2012 Today, insulin analogs are used in millions of diabetic patients. Insulin analogs have been developed to achieve more physiological insulin replacement in terms of time course of the effect.
Laura eSciacca +2 more
doaj +1 more source
Frontiers in Endocrinology, 2015 Insulin-like peptides, such as insulin and insulin-like growth factors (IGFs), induce a variety of bioactivities, such as growth, differentiation, survival, increased anabolism and decreased catabolism in many cell types and in vivo.
Fumihiko eHakuno +12 more
doaj +1 more source
Mode Localization in the Cooperative Dynamics of Protein Recognition [PDF]
, 2015 The biological function of proteins is encoded in their structure and expressed through the mediation of their dynamics. Local fluctuations are known to initiate biologically relevant pathways as they cooperatively enhance the dynamics in specific regions in the protein.
arxiv +1 more source
Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020 The mechanism of development of insulin resistance is not fully deciphered. Disorders that lead to insulin resistance can occur at the following levels of the insulin signaling pathway: pre-receptor (abnormal insulin), receptor (reduced number or affnity
Nikonova L. V. +2 more
doaj +1 more source
Impairment of insulin-stimulated glucose utilization is associated with burn-induced insulin resistance in mouse muscle by hyperinsulinemic-isoglycemic clamp [PDF]
arXiv, 2020 Burn-induced insulin resistance is associated with increased morbidity and mortality; however, the impact of burn injury on tissue-specific insulin sensitivity and its molecular mechanisms with consideration of insulin state remains unknown in rodent models.
arxiv
Tissue-specific regulation of IRS-1 in unilaterally nephrectomized rats
Brazilian Journal of Medical and Biological Research, 1997 Insulin stimulates the tyrosine kinase activity of its receptor, resulting in the phosphorylation of its cytosolic substrate, insulin receptor substrate 1 (IRS-1).
A.D. Sasse +5 more
doaj +1 more source
Haematologica, 2012 Background In normal platelets, insulin inhibits agonist-induced Ca2+ mobilization by raising cyclic AMP. Platelet from patients with type 2 diabetes are resistant to insulin and show increased Ca2+ mobilization, aggregation and procoagulant activity. We
Anja J. Gerrits +5 more
doaj +1 more source
Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa
Cell Death and Disease, 2022 Synaptic loss, neuronal death, and circuit remodeling are common features of central nervous system neurodegenerative disorders. Retinitis pigmentosa (RP), the leading cause of inherited blindness, is a group of retinal dystrophies characterized by ...
Alonso Sánchez-Cruz +9 more
doaj +1 more source
Brain Insulin Resistance: Focus on Insulin Receptor-Mitochondria Interactions
Life, 2021 Current hypotheses implicate insulin resistance of the brain as a pathogenic factor in the development of Alzheimer’s disease and other dementias, Parkinson’s disease, type 2 diabetes, obesity, major depression, and traumatic brain injury.
Igor Pomytkin, Vsevolod Pinelis
doaj +1 more source