Evidence-Based Complementary and Alternative Medicine, 2011 β-Endorphin plays a major role in the amelioration of insulin resistance. The present study documents that myricetin (3,5,7,3′, 4′, 5′-hexahydroxyflavone) ameliorates insulin resistance by enhancing β-endorphin production in insulin-resistant rats.
T. Tzeng, S. Liou, I. Liu
semanticscholar +1 more source
Inhibition of Y1 receptor signaling improves islet transplant outcome [PDF]
, 2017 Failure to secrete sufficient quantities of insulin is a pathological feature of type-1 and type-2 diabetes, and also reduces the success of islet cell transplantation.
A Ali-Rachedi +46 more
core +5 more sources
Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures
Nature Communications, 2022 DNA aptamers can activate insulin receptor as selective agonists or positive allosteric modulators. Here, authors determine structures of the insulin receptor bound to aptamers and provide a basis for the selective activation or allosteric regulation of ...
Junhong Kim +8 more
doaj +1 more source
Differential pathways to adult metabolic dysfunction following poor nutrition at two critical developmental periods in sheep [PDF]
, 2014 Epidemiological and experimental studies suggest early nutrition has long-term effects on susceptibility to obesity, cardiovascular and metabolic diseases.
Brewin, Andrew +10 more
core +11 more sources
Magnesium supplementation enhances insulin sensitivity and decreases insulin resistance in diabetic rats [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Diabetes mellitus has been suggested to be the most common metabolic disorder associated with magnesium deficiency. This study aimed to investigate the effects and mechanisms of magnesium supplementation on insulin receptor activity in ...
Hongzhou Liu +5 more
doaj +1 more source
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites [PDF]
, 2016 Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T ...
Acevedo-Suárez +59 more
core +2 more sources
The Insulin Receptor Mediates Insulin’s Early Plasma Clearance by Liver, Muscle, and Kidney
Biomedicines, 2021 The role of the insulin receptor in mediating tissue-specific insulin clearance in vivo has not been reported. Using physiologic insulin doses, we measured the initial clearance rate (first 5 min) of intravenously injected ([125I]TyrA14)-insulin by ...
Rick I. Meijer, Eugene J. Barrett
doaj +1 more source
Insulin transport across the blood–brain barrier can occur independently of the insulin receptor
Journal of Physiology, 2018 Insulin enters the brain from the blood via a saturable transport system. It is unclear how insulin is transported across the blood–brain barrier (BBB).
E. Rhea, C. Rask-Madsen, W. Banks
semanticscholar +1 more source
Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake [PDF]
, 2014 Virtually all diabetic dogs require exogenous insulin therapy to control their hyperglycaemia. In the UK, the only licensed insulin product currently available is a purified porcine insulin preparation.
Angela L. Holder +23 more
core +1 more source
Insulin receptor-inspired soluble insulin binder
European Journal of Cell Biology, 2023 The insulin receptor (IR) is a 320 kDa membrane receptor tyrosine kinase mediating the pleiotropic actions of insulin, leading to phosphorylation of several intracellular substrates including serine/threonine-protein kinase (AKT1), and IR ...
Christopher Mendoza +6 more
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