Results 31 to 40 of about 3,230,451 (211)

Insulin transport across the blood–brain barrier can occur independently of the insulin receptor

Journal of Physiology, 2018
Insulin enters the brain from the blood via a saturable transport system. It is unclear how insulin is transported across the blood–brain barrier (BBB).
E. Rhea, C. Rask-Madsen, W. Banks
semanticscholar   +1 more source

Landmarks in insulin research

Frontiers in Endocrinology, 2011
Ever since the discovery of insulin and its role in the regulation of glucose uptake and utilization, there has been great interest in insulin, its structure and the way in which it interacts with its receptor and effects signal transduction. As the 90th
Michael eLawrence, Michael eLawrence
doaj   +1 more source

Insulin receptor has tyrosine kinase activity toward Shc in rat liver

Brazilian Journal of Medical and Biological Research, 1998
Insulin induces tyrosine phosphorylation of Shc in cell cultures and in insulin-sensitive tissues of the intact rat. However, the ability of insulin receptor (IR) tyrosine kinase to phosphorylate Shc has not been previously demonstrated.
E.V. Páez-Espinosa, C.R.O. Carvalho, L.A. Velloso, M.J.A. Saad   +3 more
doaj   +1 more source

The Insulin Receptor Mediates Insulin’s Early Plasma Clearance by Liver, Muscle, and Kidney

Biomedicines, 2021
The role of the insulin receptor in mediating tissue-specific insulin clearance in vivo has not been reported. Using physiologic insulin doses, we measured the initial clearance rate (first 5 min) of intravenously injected ([125I]TyrA14)-insulin by ...
Rick I. Meijer, Eugene J. Barrett
doaj   +1 more source

Inhibition of D4 Dopamine Receptors on Insulin Receptor Expression and Effect in Renal Proximal Tubule Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundIon transport in the renal proximal tubule (RPT), which is increased in essential hypertension, is regulated by numerous hormones and humoral factors, including insulin and dopamine. Activation of dopamine receptor inhibits sodium reabsorption,
Ye Zhang, Hongmei Ren, Xi Lu, Duofen He, Yu Han, Hongyong Wang, Chunyu Zeng, Weibin Shi   +7 more
doaj   +1 more source

Insulin analogs and cancer

Frontiers in Endocrinology, 2012
Today, insulin analogs are used in millions of diabetic patients. Insulin analogs have been developed to achieve more physiological insulin replacement in terms of time course of the effect.
Laura eSciacca, Rosario eLe Moli, Riccardo eVigneri   +2 more
doaj   +1 more source

Adapter Function of Protein-tyrosine Phosphatase 1D in Insulin Receptor/Insulin Receptor Substrate-1 Interaction (*)

Journal of Biological Chemistry, 1995
Insulin signal transduction involves the multisite docking protein insulin receptor substrate-1 (IRS-1) and a number of Src homology-2 (SH2) domain factors, including p85/p110 phosphatidylinositol 3-kinase, p110 GTPase-activating protein, and the ...
A. Kharitonenkov, J. Schnekenburger, Zhengjun Chen, P. Knyazev, Suhad Ali, Esther Zwick, M. White, A. Ullrich   +7 more
semanticscholar   +1 more source

The novel functions of high-molecular-mass complexes containing insulin receptor substrates in mediation and modulation of insulin-like activities: Emerging concept of diverse function by IRS-associated proteins

Frontiers in Endocrinology, 2015
Insulin-like peptides, such as insulin and insulin-like growth factors (IGFs), induce a variety of bioactivities, such as growth, differentiation, survival, increased anabolism and decreased catabolism in many cell types and in vivo.
Fumihiko eHakuno, Toshiaki eFukushima, Toshiaki eFukushima, Yosuke eYoneyama, Hiroyasu eKamei, Atsufumi eOzoe, Hidehito eYoshihara, Daisuke eYamanaka, Takashi eShibano, Meri eSone-Yonezawa, Bu-Chin eYu, Kazuhiro eChida, Shin-Ichiro eTakahashi   +12 more
doaj   +1 more source

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non‐human primate model of Alzheimer's disease

Journal of Pathology, 2018
Alzheimer's disease (AD) is a devastating neurological disorder that still lacks an effective treatment, and this has stimulated an intense pursuit of disease‐modifying therapeutics.
A. F. Batista, Letícia Forny‐Germano, J. Clarke, Natalia M. Lyra e Silva, Jordano Brito‐Moreira, S. Boehnke, A. Winterborn, B. Coe, Ann Lablans, Juliana F. S. Vital, S. A. Marques, Anita M. Martinez, Matthias Gralle, C. Holscher, W. Klein, J. Houzel, S. Ferreira, D. Munoz, F. D. De Felice   +18 more
semanticscholar   +1 more source

ROLE OF MUTATION OF INSULIN RECEPTOR GENES IN THE DEVELOPMENT OF THE PHENOMENON OF INSULIN RESISTANCE

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
The mechanism of development of insulin resistance is not fully deciphered. Disorders that lead to insulin resistance can occur at the following levels of the insulin signaling pathway: pre-receptor (abnormal insulin), receptor (reduced number or affnity
Nikonova L. V., Tishkovskiy S. V., Butrim O. S.   +2 more
doaj   +1 more source