Oral Melatonin in Critically Ill Patients With COVID‐19: A Quasi‐Experimental Pragmatic Trial
Journal of Medical Virology, Volume 98, Issue 1, January 2026.ABSTRACT Melatonin has demonstrated antioxidant, anti‐inflammatory, and potential antiviral properties. Its therapeutic role in critically ill COVID‐19 patients admitted to intensive care was underexplored at the start of the pandemic. We conducted a quasi‐experimental, pragmatic study over 4 consecutive uninterrupted time periods alternating control ...
Miguel Sánchez‐García +22 more
wiley +1 more source
Melatonin alleviates aging-related heart failure through melatonin receptor 1A/B knockout in mice
HeliyonAge-related cardiovascular diseases continue to be important issues that contribute to the societal burden. Unveiling the molecular mechanisms underlying age-related cardiovascular diseases provides novel opportunities to delay aging and facilitate early
Zhenyu Feng +6 more
doaj +1 more source
The role of the mammalian prion protein in the control of sleep [PDF]
, 2017 Sleep disruption is a prevalent clinical feature in many neurodegenerative disorders, including human prion diseases where it can be the defining dysfunction, as in the case of the “eponymous” fatal familial insomnia, or an early-stage symptom as in ...
Gill, Andrew C., Roguski, Amber
core +2 more sources
How to cite curated databases and how to make them citable [PDF]
, 2006 Curated scientific databases such as the IUPHAR database resemble conventional publications such as reference manuals in that they represent the work of a large number of people who both create and revise their contents.
Buneman, Peter
core +1 more source
Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression [PDF]
, 2007 G protein-coupled receptors are key regulators of cellular communication, mediating the efficient coordination of a cell's responses to extracellular stimuli.
New, David C., Wong, Yung Hou
core +1 more source
Anti-oxidants in Parkinson's disease therapy: a critical point of view [PDF]
, 2016 Parkinson's disease (PD) is a degenerative neurological syndrome, which is characterized by the preferential death of dopaminergic (DAergic) neurons in the SubstantiaNigra.
Beltramini, Mariano +3 more
core +2 more sources
Chimeric Melatonin mt1 and Melatonin-related Receptors [PDF]
Journal of Biological Chemistry, 2000 Shaun Conway +5 more
openaire +1 more source
Inhibition of prostate cancer cell growth by human secreted PDZ domain-containing protein 2, a potential autocrine prostate tumor suppressor [PDF]
, 2006 A possible role of the PDZ domain-containing protein 2 (PDZD2) in prostate tumorigenesis has been suggested. Besides, PDZD2 is posttranslationally cleaved by a caspase-dependent mechanism to form a secreted PDZ domain-containing protein 2 (sPDZD2) with ...
Cheng, AS +4 more
core +1 more source
[MT1 melatonin receptors and their role in the oncostatic action of melatonin].
Postepy higieny i medycyny doswiadczalnej (Online), 2010 Melatonin, the main hormone produced by the pineal gland, strongly inhibits the growth of cancer cells in vitro and in vivo. Some publications indicate that the addition of melatonin to culture medium slows the proliferation of some cancer cell lines.
Karolina, Danielczyk, Piotr, Dziegiel
openaire +1 more source
Melatonin limits paclitaxel-induced mitochondrial dysfunction in vitro and protects against paclitaxel-induced neuropathic pain in the rat [PDF]
, 2017 Acknowledgements Thank you to Professor Ahmet Hoke (Johns Hopkins, Baltimore, USA) for the gift of DRG cells; and to Professor Patrick M. Dougherty (MD Anderson Cancer Center, Texas, USA) for sharing his expertise in the rat model.
Agnello +73 more
core +4 more sources