Results 11 to 20 of about 6,476 (207)
Dynamics of the melatonin MT1 receptor in the rat parotid gland upon melatonin administration [PDF]
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2016 Our recent ultrastructural study of human parotid glands revealed that the melatonin receptors, MT1 and MT2, are localised in the plasma cell membranes of acinar and ductal cells but also, and intriguingly, predominantly in acinar secretory granules ...
Ekstrom, J +4 more
core +3 more sources
Suicidal Ideation Following a Single Dose of Melatonin in a Patient With Major Depressive Disorder: A Case Report. [PDF]
Clin Case RepABSTRACT Melatonin is a neurohormone that primarily regulates sleep patterns and circadian rhythms by interacting with melatonin receptors MT1 and MT2. Disruptions in circadian rhythms may contribute to mood disorders; for example, individuals with major depressive disorder often have significantly lower melatonin levels compared to healthy individuals.
Badrfam R, Zandifar A.
europepmc +2 more sources
Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks. [PDF]
PLoS ONE, 2016 Melatonin is rhythmically secreted by both the pineal gland and retina in a circadian fashion, with its peak synthesis occurring during the night. Once synthesized, melatonin exerts its effects by binding to two specific G-protein coupled receptors ...
Sharon Owino +3 more
doaj +1 more source
Modeling the Heterodimer Interfaces of Melatonin Receptors
Frontiers in Cellular Neuroscience, 2021 Melatonin receptors are Class A G protein-coupled receptors (GPCRs) that regulate a plethora of physiological activities in response to the rhythmic secretion of melatonin from the pineal gland.
Lap Hang Tse +3 more
doaj +1 more source
Melatonin Transmits Photoperiodic Signals through the MT1 Melatonin Receptor [PDF]
The Journal of Neuroscience, 2009 Melatonin transmits photoperiodic signals that regulate reproduction. Two melatonin receptors (MT1 and MT2) have been cloned in mammals and additional melatonin binding sites suggested, but the receptor that mediates the effects of melatonin on the photoperiodic gonadal response has not yet been identified. We therefore investigated in mice whether and
Shinobu, Yasuo +3 more
openaire +2 more sources
Expression of the MT1 Melatonin Receptor in Ovarian Cancer Cells [PDF]
International Journal of Molecular Sciences, 2014 Ovarian cancer (OC) is the leading cause of death among women with genital tract disorders. Melatonin exhibits oncostatic properties which it may effect through binding to its membrane receptor, MT1. The aim of this study was to determine the expression of MT1 in OC cells and to correlate this with clinical and pathological data.
Karolina Jablonska +9 more
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2021 It is well known that hypoxanthine (HX) inhibits nuclear maturation of oocytes by elevating the intracellular cAMP level, while melatonin (MT) is a molecule that reduces cAMP production, which may physiologically antagonize this inhibition and restore ...
Jing Wang +11 more
doaj +1 more source
Distribution of Melatonin MT1 Receptor Immunoreactivity in Human Retina [PDF]
Journal of Histochemistry & Cytochemistry, 2002 Melatonin is synthesized in the pineal gland and retina during the night. Retinal melatonin is believed to be involved in local cellular modulation and in regulation of light-induced entrainment of circadian rhythms. The present study provides the first immunohistochemical evidence for the localization of melatonin 1a-receptor (MT1) in human retina of
Savaskan, Egemen +8 more
openaire +3 more sources
Role of melatonin receptors in the effect of estrogen on brain edema, intracranial pressure and expression of aquaporin 4 after traumatic brain injury [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Traumatic brain injury (TBI) is one of the most common causes of death and disability in modern societies. The role of steroids and melatonin is recognized as a neuroprotective factor in traumatic injuries.
Nader Shahrokhi +4 more
doaj +1 more source
Preliminary Evaluation of Human Gingiva as an Extrapineal Site of Melatonin Biosynthesis in States of Periodontal Health and Disease [PDF]
Journal of Clinical and Diagnostic Research, 2018 Introduction: Melatonin is a pineal gland hormone that plays an important role in periodontal homeostasis. Extra pineal melatonin production has been found to occur in tissues like the ovaries, retina and gastrointestinal tract.
Balaji Thodur Madapusi, Suresh Ranga Rao
doaj +1 more source