Expression of melatonin receptors in trigeminal and sphenopalatine ganglia: potential targets for primary headache disorders [PDF]
The Journal of Headache and PainBackground Primary headache disorders such as migraine and cluster headache exhibit circadian and circannual variations in attack onset. Melatonin plays a central role in regulating biological rhythms and likely influences the timing of headache attacks.
Aida Maddahi +3 more
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Melatonin inhibits muscular-mucosal stretch-sensitive bladder afferents via the MT2 receptors
Scientific Reports, 2022 Melatonin is a circadian rhythm regulator capable of controlling a variety of physiological processes in the body. It predominantly acts via the melatonin 1 (MT1) and MT2 receptors expressed in the CNS neurons and peripheral organs and tissues. Melatonin
Stewart Ramsay, Vladimir Zagorodnyuk
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Sperm freezability is associated with melatonin receptor expression in the sperm plasma membrane of Saanen goat bucks (Capra hircus) [PDF]
Veterinary WorldBackground and Aim: Cryopreservation is an essential assisted reproductive technology for preserving valuable animal genetics; however, it induces osmotic and oxidative stress that compromises sperm quality.
Alberto J. Cardenas-Padilla +1 more
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MT2 receptor mediates melatonin-induced thermogenic program in human myoblasts: insights for circadian syndrome and diabesity treatment [PDF]
Frontiers in PharmacologyBackgroundMelatonin is crucial for regulating circadian rhythms. Previous studies have demonstrated its ability to improve metabolic disorders, including obesity and associated diabetes (diabesity), in addition to its antioxidant, anti-inflammatory and ...
Diego Salagre +5 more
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Modeling the Heterodimer Interfaces of Melatonin Receptors
Frontiers in Cellular Neuroscience, 2021 Melatonin receptors are Class A G protein-coupled receptors (GPCRs) that regulate a plethora of physiological activities in response to the rhythmic secretion of melatonin from the pineal gland.
Lap Hang Tse +3 more
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Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks. [PDF]
PLoS ONE, 2016 Melatonin is rhythmically secreted by both the pineal gland and retina in a circadian fashion, with its peak synthesis occurring during the night. Once synthesized, melatonin exerts its effects by binding to two specific G-protein coupled receptors ...
Sharon Owino +3 more
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Role of melatonin receptors in the effect of estrogen on brain edema, intracranial pressure and expression of aquaporin 4 after traumatic brain injury [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Traumatic brain injury (TBI) is one of the most common causes of death and disability in modern societies. The role of steroids and melatonin is recognized as a neuroprotective factor in traumatic injuries.
Nader Shahrokhi +4 more
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Medycyna Ogólna i Nauki o Zdrowiu, 2022 Introduction and objective Melatonin is the most important compound produced by the pineal gland. Its daily secretion cycle is responsible for the normal rhythm of sleep and wakefulness.
Sara Hmaidan +3 more
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Cells, 2022 There is growing concern that chemotherapy drugs can damage Leydig cells and inhibit the production of testosterone. Increasing evidence shows that melatonin benefits the reproductive process. This study mainly explores the protective effect and possible
Junqiang Zhang +17 more
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Scientific Reports, 2022 Melatonin is a known modulator of follicle development; it acts through several molecular cascades via binding to its two specific receptors MT1 and MT2. Even though it is believed that melatonin can modulate granulosa cell (GC) functions, there is still
Asma Arjoune, Marc-André Sirard
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