Results 31 to 40 of about 3,161 (162)

Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction [PDF]

Journal of Psychopharmacology, 2021
Background: Aside from regulating circadian rhythms, melatonin also affects cognitive processes, such as alertness, and modulates the brain circuitry underlying psychiatric diseases, such as depression, schizophrenia and bipolar disorder, via mechanisms that are not fully clear.
Thomson, David M., Mitchell, Emma J., Openshaw, Rebecca L., Pratt, Judith A., Morris, Brian J.   +4 more
openaire   +5 more sources

Melatonin inhibits granulocyte adhesion to ICAM via MT3/QR2 and MT2 receptors [PDF]

International Immunology, 2015
AbstractNeutrophils are cells of the innate immune system that first respond and arrive to the site of infection. Melatonin modulates acute inflammatory responses by interfering with leukocyte recruitment. It is known that melatonin modulates granulocyte migration though the endothelial layer thereby acting on the endothelial cell. Here we investigated
Vitalij, Černyšiov, Mykolas, Mauricas, Irute, Girkontaite   +2 more
openaire   +2 more sources

MT1 and MT2 melatonin receptors play opposite roles in brain cancer progression

Journal of Molecular Medicine, 2021
Primary brain tumors remain among the deadliest of all cancers. Glioma grade IV (glioblastoma), the most common and malignant type of brain cancer, is associated with a 5-year survival rate of
G. S. Kinker, L. H. Ostrowski, P. A. C. Ribeiro, R. Chanoch, S. M. Muxel, I. Tirosh, G. Spadoni, S. Rivara, V. R. Martins, T. G. Santos, R. P. Markus, P. A. C. M. Fernandes   +11 more
openaire   +3 more sources

Empowering Melatonin Therapeutics with Drosophila Models

Diseases, 2021
Melatonin functions as a central regulator of cell and organismal function as well as a neurohormone involved in several processes, e.g., the regulation of the circadian rhythm, sleep, aging, oxidative response, and more.
Cassandra Millet-Boureima, Caroline C. Ennis, Jurnee Jamison, Shana McSweeney, Anna Park, Chiara Gamberi   +5 more
doaj   +1 more source

In-vivo Thermal Stress Induces Melatonin Receptors and Heat Shock Proteins Expression in the Spleen of Mice in a Time and Temperature Dependent Manner [PDF]

Journal of Stress Physiology & Biochemistry, 2023
Heat shock proteins (Hsps) responses against stress conditions. Melatonin completes its stress relieving activities via its MT1 and MT2 receptors. The present study delineates the expression pattern of Hsp70/Hsc70 and MT1/MT2 receptor proteins along with
Samik Acharjee, Shiv Shankar Singh
doaj  

Human Gastroenteropancreatic Expression of Melatonin and Its Receptors MT1 and MT2

PLOS ONE, 2015
The largest source of melatonin, according to animal studies, is the gastrointestinal (GI) tract but this is not yet thoroughly characterized in humans. This study aims to map the expression of melatonin and its two receptors in human GI tract and pancreas using microarray analysis and immunohistochemistry.Gene expression data from normal intestine and
Söderquist, Fanny, Hellström, Per M., Cunningham, Janet L.   +2 more
openaire   +5 more sources

Melatonin in Th17/Treg differentiation: the contribution of the hormone's own production by T lymphocytes

Медицинская иммунология, 2023
The hormone melatonin is involved in regulation of functioning of almost all organs and systems of the organism. In the immune system, T lymphocytes are an important target of melatonin: they express specific melatonin receptors with different affinities
N. S. Glebezdina, E. M. Kuklina, I. V. Nekrasova   +2 more
doaj   +1 more source

Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep

Frontiers in Endocrinology, 2019
The pathophysiological function of the G-protein coupled melatonin MT1 and MT2 receptors has not yet been well-clarified. Recent advancements using selective MT1/ MT2 receptor ligands and MT1/MT2 receptor knockout mice have suggested that the activation ...
Gabriella Gobbi, Stefano Comai, Stefano Comai   +2 more
doaj   +1 more source

Structure-based discovery of potent and selective melatonin receptor agonists

eLife, 2020
Melatonin receptors MT1 and MT2 are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer.
Nilkanth Patel, Xi Ping Huang, Jessica M Grandner, Linda C Johansson, Benjamin Stauch, John D McCorvy, Yongfeng Liu, Bryan Roth, Vsevolod Katritch   +8 more
doaj   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source