Results 51 to 60 of about 3,161 (162)

Gestational Melatonin Supplementation Attenuates Maternal Sleep Deprivation‐Induced Steatohepatitis Susceptibility in Offspring

Cell Proliferation, EarlyView.
Maternal SD during pregnancy enhances the development of diet‐induced NASH in adult offspring of both sexes through an NR4A3‐dependent mechanism, characterised by heightened inflammation and increased apoptosis. Maternal melatonin supplementation effectively alleviates this increased susceptibility to NASH in offspring.
Fei Guo, Zexin Yang, Junsen She, Chen Fang, Yizhi Hu, Hefeng Huang, Ling Gao   +6 more
wiley   +1 more source

Melatonin modulates neuroinflammatory response and microglial activation in mice exposed to dim blue light at night

Frontiers in Pharmacology
ObjectivesDim light at night contributes to neurodegenerative diseases by causing neuroinflammation. In the central nervous system, the activation of microglia is a significant contributor to neuroinflammation.
Chao Song, Zhaotaize Suo, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen   +5 more
doaj   +1 more source

Melatonin MT1 and MT2 Receptors in the Ram Reproductive Tract [PDF]

International Journal of Molecular Sciences, 2017
Some melatonin functions in mammals are exerted through MT1 and MT2 receptors. However, there are no reports of their presence in the reproductive tract of the ram, a seasonal species. Thus, we have investigated their existence in the ram testis, epididymis, accessory glands and ductus deferens.
Marta González-Arto, David Aguilar, Elena Gaspar-Torrubia, Margarita Gallego, Melissa Carvajal-Serna, Luis Herrera-Marcos, Edith Serrano-Blesa, Thais Hamilton, Rosaura Pérez-Pé, Teresa Muiño-Blanco, José Cebrián-Pérez, Adriana Casao   +11 more
openaire   +2 more sources

Sleep Deprivation Alters T Cell Dynamics: Melatonin as a Restorative Agent

Journal of Sleep Research, EarlyView.
ABSTRACT Sleep is an essential physiological function regulated by circadian rhythm and homeostatic regulation for emotional and physical health. Conversely, sleep deprivation (SD) is associated with weakened immune system function and overall health, which potentially leads to chronic diseases such as heart disease and diabetes.
Hilal Öztürk, Hakan Çalış, Yusuf Metin Gelmez, Günnur Deniz, Abdullah Yılmaz, Mahmut Alp Kılıç, Nermin Yelmen, Zozan Güleken, Devrim Saribal   +8 more
wiley   +1 more source

Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer’s disease

European Journal of Histochemistry, 2009
The pineal hormone melatonin is involved in physiological transduction of temporal information from the light dark cycle to circadian and seasonal behavioural rhythms, as well as possessing neuroprotective properties.
P Brunner, N Sözer-Topcular, R Jockers, R Ravid, D Angeloni, F Fraschini   +5 more
doaj   +1 more source

Melatonin restores Muc2 depletion induced by V. vulnificus VvpM via melatonin receptor 2 coupling with Gαq

Journal of Biomedical Science, 2020
Background Melatonin (5-methoxy-N-acetyltryptamine), a hormone produced in the pineal gland, has a variety of biological functions as an antioxidant, but a functional role of melatonin in the regulation of intestinal mucin (Muc) production during ...
Young-Min Lee, Jong Pil Park, Young Hyun Jung, Hyun Jik Lee, Jun Sung Kim, Gee Euhn Choi, Ho Jae Han, Sei-Jung Lee   +7 more
doaj   +1 more source

The Impact of Melatonin and its Agonist on Endothelin-1 Reactivity in Isolated Aorta in Continuous Light and Pinealectomized Rats

Zanco Journal of Pure and Applied Sciences, 2023
   The purpose of the present study is to investigate the influence of melatonin and its receptor (MT1, and MT2) agonist (Ramelteon) on vascular endothelin-1 (ET-1) reactivity in isolated aortic rings in continuous light emitting diode (LED) exposure ...
Evan B. Othman, Ismail M. Maulood
doaj   +1 more source

Effects of Agomelatine on Sleep Across Populations: A Systematic Review and Meta‐Analysis

Journal of Sleep Research, EarlyView.
ABSTRACT Agomelatine, a melatoninergic antidepressant, is often prescribed to improve sleep disturbance, though meta‐analytic evidence is currently lacking. This systematic review and meta‐analysis assessed its efficacy and tolerability in sleep outcomes compared to placebo.
Anastasios Stefanou, Ioannis Anastasiou, Panagiota Fallon, Eleni Glarou, Nikolaos Christodoulou, Andreas S. Lappas, Vasilios‐Panteleimon Bozikas, Myrto T. Samara   +7 more
wiley   +1 more source

Melatonin Attenuates Anoxia/Reoxygenation Injury by Inhibiting Excessive Mitophagy Through the MT2/SIRT3/FoxO3a Signaling Pathway in H9c2 Cells

Drug Design, Development and Therapy, 2020
Jinjing Wu,* Yanli Yang,* Yafen Gao, Zhaoqi Wang, Jun Ma Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University-Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, People’s Republic of China*These authors ...
Wu J, Yang Y, Gao Y, Wang Z, Ma J
doaj  

The role of agomelatine in appetite regulation and body weight in rats

Experimental Physiology, EarlyView.
Abstract The hypothalamic nuclei play a central role in the synthesis of anorexigenic and orexigenic neuropeptides, which are regulated by peripheral hormones, like leptin and ghrelin. Melatonergic receptors (MT1/MT2) are prominently expressed in the arcuate nucleus of the hypothalamus – an essential hub for appetite control – and in peripheral ...
Engin Korkmaz, Yavuz Erden, Çiğdem Tekin, Suat Tekin   +3 more
wiley   +1 more source