Results 61 to 70 of about 3,161 (162)

Melatonergic Signaling Sustains Food Allergy Through FcεRI Recycling

Research
The prevalence of food allergies is increasing dramatically and causing serious public health concerns. Notably, melatonin metabolism imbalance in patients with food allergies; however, the role of melatonin in food allergies remains unclear.
Youxia Wang, Xinmei Zhang, Ifen Hung, Chunxue Liu, Wenkai Ren, Liangpeng Ge, Hao Wang   +6 more
doaj   +1 more source

Behavioral Phenotype and Neuropsychological Profile of an Adult With Smith‐Magenis Syndrome due to a Previously Unreported RAI1 Mutation: A Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Smith‐Magenis Syndrome (SMS) is an uncommon genetic disorder caused by microdeletions of chromosome 17p11.2 including the RAI1 gene, or loss‐of‐function mutations that directly affect RAI1. Due to the involvement of RAI1 in neurodevelopment, SMS leads to typical pathologic features in the behavioral and physical phenotype that must be ...
Edgar Andrés Chavarría‐Martínez, Julen Arellano‐Sandúa, Ruth Arias‐Hidalgo, Ana Patiño‐García, Adrián Cano‐Prous   +4 more
wiley   +1 more source

Correlation between sleep problems and morning serum melatonin and ferritin levels in Japanese 5‐year‐old children with autism spectrum disorder

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 1, March 2026.
Abstract Aim Children with autism spectrum disorder (ASD) are more likely to have sleep problems. Few studies have investigated the relationship between sleep problems and blood melatonin and ferritin levels. The objective of this study was to determine the correlation between sleep problems and morning serum melatonin and ferritin levels, and the ...
Ai Terui, Manabu Saito, Asami Kuki, Shuji Shimoyama, Yui Sakamoto, Kazutaka Yoshida, Ayako Osato, Kazuhiko Nakamura   +7 more
wiley   +1 more source

Sleep quality and sleepiness in adults with multiple myeloma. Is melatonin a potential treatment?

Physiological Reports, Volume 14, Issue 5, March 2026.
Abstract Sleep disturbances significantly impact quality of life in cancer patients, yet remain poorly characterized in multiple myeloma (MM). This observational study aimed to characterize sleep profiles in MM patients and evaluate the therapeutic potential of exogenous melatonin.
Mariana Fiori, Evellyn M. de Azevedo, Lais S. Rodrigues, Kamily S. Turt, Daniel Pacheco Bruschi, Marcelo M. S. Lima   +5 more
wiley   +1 more source

New Insights on Heat Shock Proteins as Regulators of Reactive Oxygen Species Across Various Stressors in Diseases

Cell Biochemistry and Function, Volume 44, Issue 2, February 2026.
ABSTRACT Living beings are persistently challenged by stress. Stress can be induced by internal stressors and external stressors. External stressors, including radiation, heat, heavy metals, nutritional imbalances, infections, and psychological stress, can induce protein denaturation, leading to misfolded or aggregated proteins.
Paka Sravan Kumar, Triveni Kodi, Adarsh Gopinathan, Bharath Harohalli Byregowda, Krishnadas Nandakumar, Anoop Kishore   +5 more
wiley   +1 more source

Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study

Frontiers in Physiology, 2020
BackgroundMelatonin modulates circadian rhythms in physiology and sleep initiation. Genetic variants of the MTNR1B locus, encoding the melatonin MT2 receptor, have been associated with increased type 2 diabetes (T2D) risk. Carriers of the common intronic
Akram Imam, Eva C. Winnebeck, Nina Buchholz, Philippe Froguel, Philippe Froguel, Amélie Bonnefond, Amélie Bonnefond, Michele Solimena, Anna Ivanova, Michel Bouvier, Bianca Plouffe, Bianca Plouffe, Guillaume Charpentier, Angeliki Karamitri, Ralf Jockers, Till Roenneberg, Céline Vetter, Céline Vetter   +17 more
doaj   +1 more source

Exogenous Melatonin and Sleep Quality: A Scoping Review of Systematic Reviews

The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.
Abstract Melatonin is increasingly used to treat sleep disturbances, yet its overall efficacy remains unclear due to variability in existing evidence. This scoping review aimed to synthesize systematic reviews with meta‐analyses assessing the effects of exogenously administered melatonin on sleep quality in humans.
Samyuktha Iyer, Vaneesha Monk, Rebeccah Slater, Luke Baxter   +3 more
wiley   +1 more source

Melatonin and diabetes: from pathophysiology to the treatment perspectives

Сахарный диабет, 2013
Pineal hormone melatonin synchronizes insulin secretion and glucose homeostasis with solar periods. Misalliance between melatonin-mediated circadian rhythms and insulin secretion characterizes diabetes mellitus type 1 (T1DM) and type 2 (T2DM).
Vladimir Iosifovich Konenkov, Vadim Valerievich Klimontov, Svetlana Viktorovna Michurina, M A Prudnikova, I Ju Ishenko   +4 more
doaj   +1 more source

Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2011
In bile duct-ligated (BDL) rats, large cholangiocytes proliferate by activation of cAMP-dependent signaling. Melatonin, which is secreted from pineal gland as well as extrapineal tissues, regulates cell mitosis by interacting with melatonin receptors (MT1 and MT2) modulating cAMP and clock genes.
Anastasia, Renzi, Shannon, Glaser, Sharon, Demorrow, Romina, Mancinelli, Fanyin, Meng, Antonio, Franchitto, Julie, Venter, Mellanie, White, Heather, Francis, Yuyan, Han, Domenico, Alvaro, Eugenio, Gaudio, Guido, Carpino, Yoshiyuki, Ueno, Paolo, Onori, Gianfranco, Alpini   +15 more
openaire   +3 more sources

A Randomized, Triple‐Blind, Placebo‐Controlled, Parallel Clinical Trial Investigating Safety and Efficacy of Corn Leaf Extract on Sleep Quality in a Healthy Population With Difficulty Falling or Staying Asleep

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Corn leaf extract (CLE) contains a naturally occurring substance, 6‐methoxybenzoxazolinone (6‐MBOA). Structurally similar to melatonin, 6‐MBOA acts as a weak β‐adrenergic agonist with an affinity for melatonin receptors and stimulating melatonin synthesis.
Katarina M. Doma, Abdelrahman Zamzam, David C. Crowley, Najla Guthrie, Erin D. Lewis   +4 more
wiley   +1 more source