Results 71 to 80 of about 3,161 (162)

Higher melatonin in the follicle fluid and MT2 expression in the granulosa cells contribute to the OHSS occurrence

Reproductive Biology and Endocrinology, 2019
Background Ovarian hyperstimulation syndrome (OHSS) is a common and severe complication for patients undergoing IVF/ICSI-ET. Melatonin widely participates in the regulation of female reproductive endocrine activity.
Yiran Li, Lanlan Fang, Yiping Yu, Hao Shi, Sijia Wang, Yanjie Guo, Yingpu Sun   +6 more
doaj   +1 more source

Integrated Analysis of the Immune Infiltration Pattern and Novel Diagnostic Biomarkers in Septic Cardiomyopathy

Immunity, Inflammation and Disease, Volume 14, Issue 1, January 2026.
In this study, various informatics analyses were employed to identify hub genes associated with the onset of septic cardiomyopathy and investigate its immune infiltration status. ABSTRACT Purpose In this study, various informatics analyses were employed to identify the hub genes associated with septic cardiomyopathy (SCM) onset and investigate their ...
Wei Liu, Xi Zheng, Dong Wang, Jingyi Wang, Xincheng Li, Fei Li, Wenxiong Li, Jin Zhang   +7 more
wiley   +1 more source

Oral Melatonin in Critically Ill Patients With COVID‐19: A Quasi‐Experimental Pragmatic Trial

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Melatonin has demonstrated antioxidant, anti‐inflammatory, and potential antiviral properties. Its therapeutic role in critically ill COVID‐19 patients admitted to intensive care was underexplored at the start of the pandemic. We conducted a quasi‐experimental, pragmatic study over 4 consecutive uninterrupted time periods alternating control ...
Miguel Sánchez‐García, Jesús A.F. Tresguerres, Manuel Álvarez‐González, Belén de la Hera, Virginia Puebla, Lidia Ybañez, José‐Manuel Martínez‐Sesmero, Antonio Blesa, Juan‐Carlos Martín‐Benítez, Fernando Martínez‐Sagasti, Paloma González‐Arenas, Sara Domingo, Cándido Pardo, Silmary Maichle, Carolina Postigo, Sara De‐Miguel, María Bringas, Raquel González‐Casanova, Viktor Yordanov, Alberto Delgado‐Iribarren, Esther Culebras, Miguel A. Armengol‐de la‐Hoz, Antonio Núñez‐Reiz   +22 more
wiley   +1 more source

A Review of Melatonin, Its Receptors and Drugs

Eurasian Journal of Medicine, 2019
After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes, melatonin, closely related to these genes, may begin to shine.
Mucahit Emet, Halil Ozcan, Lutfu Ozel, Muhammed Yayla, Zekai Halici, Ahmet Hacimuftuoglu   +5 more
doaj   +1 more source

Tryptophan Suppresses FTH1‐Driven Ferritinophagy, a Key Correlate of Prognosis in Hepatocellular Carcinoma

Cell Proliferation, Volume 59, Issue 1, January 2026.
Intracellular tryptophan levels modulate selective autophagy of FTH1 via the NCOA4 pathway. This autophagic process then inhibits 6‐HMT synthesis, which then results in an increase in reactive oxygen species and ferroptosis. ABSTRACT Hepatocellular carcinoma (HCC) remains a lethal malignancy with limited therapeutic options.
Xinxiang Cheng, Xin Ge, Chi Zhang, Xingye Yang, Zhengxin Yu, Min Zhang, Wen Cao, Qingtao Ni, Yang Liu, Songbing He, Yin Yuan   +10 more
wiley   +1 more source

Melatonin MT1 and MT2 receptor expression in Parkinson's disease.

Medical science monitor : international medical journal of experimental and clinical research, 2010
Idiopathic Parkinson disease (PD) is a multi-system disorder with a multifactorial etiology and diverse clinical phenotype. Selective, regional dopaminergic neuronal degeneration in the substantia nigra and other CNS areas including the amygdala are observed in all patients.
Nikhil, Adi, Deborah C, Mash, Yousuf, Ali, Carlos, Singer, Lina, Shehadeh, Spyridon, Papapetropoulos   +5 more
openaire   +1 more source

GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals

BMC Evolutionary Biology, 2008
Background The melatonin receptor subfamily contains three members Mel1a, Mel1b and Mel1c, found in all vertebrates except for Mel1c which is found only in fish, Xenopus species and the chicken.
Malpaux Benoit, Pontarotti Pierre, Callebaut Isabelle, Migaud Martine, Levasseur Anthony, Dufourny Laurence, Monget Philippe   +6 more
doaj   +1 more source

MT1/MT2 melatonin receptors in proinflammatory T helper cell populations

Russian Journal of Immunology
Melatonin, a pineal gland hormone, is an effective regulator of the main T helper Th1 and Th17 populations. Currently, the studies of T helpers are shifting from classical to non-classical variants of these cells, primarily to Th1-polarized Th17 lymphocytes (Th17.1), which are formed in vitro and in vivo by transformation of differentiated Th17 cells ...
Elena M. Kuklina, Irina Y. Danchenko, Tatiana V. Baidina   +2 more
openaire   +1 more source

Melatonin regulates mitochondrial function to alleviate ferroptosis through the MT2/Akt signaling pathway in swine testicular cells

Scientific Reports
Increasing evidence has shown that many environmental and toxic factors can cause testicular damage, leading to testicular ferroptosis and subsequent male reproductive disorders.
Yuanjie Zhao, Ge Qin, Biao Jiang, Jinglei Huang, Shiwen He, Hui Peng   +5 more
doaj   +1 more source

Melatonin alleviates aging-related heart failure through melatonin receptor 1A/B knockout in mice

Heliyon
Age-related cardiovascular diseases continue to be important issues that contribute to the societal burden. Unveiling the molecular mechanisms underlying age-related cardiovascular diseases provides novel opportunities to delay aging and facilitate early
Zhenyu Feng, Yang Liu, Yijin Yang, Jie Bai, Qiu-yue Lin, Yun-long Xia, Yunpeng Xie   +6 more
doaj   +1 more source