Results 81 to 90 of about 3,161 (162)

Integrating classical and quantum mechanics in melatonin receptors for structure-guided drug design

Academia Biology
Although melatonin receptor agonists are acknowledged for their therapeutic potential for managing sleep problems, the structural optimization of these compounds is made challenging by variations in crystallographic data.
Gabriela de Lima Menezes, Gabriel Vinícius Rolim da Silva, Katyanna Sales Bezerra, Marielena Vogel Saivish, Clara Sales Gurgel Ribeiro Dantas, Douglas Soares Galvão, John Fontenele Araújo, Jonas Ivan Nobre Oliveira, Roosevelt Alves da Silva, Umberto Laino Fulco   +9 more
doaj   +1 more source

Melatonin MT2 receptor (MTNR1B) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

Neuropathic pain: targeting the melatonin MT2 receptor

South African Family Practice, 2016
Neuropathic pain affects a large proportion of the population and reduces a person’s ability to perform optimally. In South Africa, there are a host of factors that hinder the correct diagnosis and treatment of neuropathic pain. Patients suffering from neuropathic pain are treated suboptimally with NSAIDS and opioids as first-line therapy.
N. Smith, H. Ismail, N. Schellack
openaire   +2 more sources

Application of Music Therapy in Improving the Sleep Quality and Mental Health of Nurses with Circadian Rhythm Sleep Disorders Caused by Work Shifts

Noise and Health
Objective: To analyze the impact of using music therapy to improve the sleep quality and mental health of nurses who suffer from circadian rhythm sleep disorders.
Xuan Wang, Ting Feng, Shuhua Liu, Jingjing Ruan   +3 more
doaj   +1 more source

Quantum mechanics insights into melatonin and analogs binding to melatonin MT1 and MT2 receptors

Scientific Reports
Melatonin receptors MT1 and MT2 are G protein-coupled receptors that mediate the effects of melatonin, a hormone involved in circadian rhythms and other physiological functions.
Gabriela de Lima Menezes, Katyanna Sales Bezerra, Jonas Ivan Nobre Oliveira, John Fontenele Araújo, Douglas Soares Galvão, Roosevelt Alves da Silva, Marielena Vogel Saivish, Umberto Laino Fulco   +7 more
doaj   +1 more source

Melatonin Suppresses NLRP3 Inflammasome Activation via SIRT1-Mediated ETS1 Deacetylation to Attenuate LPS-Induced Pyroptosis in Alveolar Epithelial Cells. [PDF]

J Inflamm Res
He F, Liu C, Yu Y, Wang Q, Li L, Chao X, Chen L, Yu C.   +7 more
europepmc   +1 more source

Structure of the melatonin-related orphan receptor, GPR50. [PDF]

Mol Cells
Shin J, Baek D, Kim J, Park J, Jeong E, Kim Y, Kim YJ, Cho Y.   +7 more
europepmc   +1 more source

Unveiling melatonin's multifaceted actions against ferroptotic neurotoxicity in ischemic stroke. [PDF]

Toxicol Rep
Boonmag S, Reiter RJ, Govitrapong P.
europepmc   +1 more source

Melatonin Biosynthesis, Receptors, and the Microbiota-Tryptophan-Melatonin Axis: A Shared Dysbiosis Signature Across Cardiac Arrhythmias, Epilepsy, Malignant Proliferation, and Cognitive Trajectories. [PDF]

Int J Mol Sci
Tavartkiladze A, Reiter RJ, Lou R, Kasradze D, Okrostsvaridze N, Revazishvili P, Maisuradze M, Dundua G, Andronikashvili I, Nozadze P, Jinchveladze D, Tavartkiladze L, Khutsishvili R, Potskhoraia T.   +13 more
europepmc   +1 more source

Physiological relevance of autocrine melatonin signaling in pineal and extrapineal sites: a systematic review. [PDF]

Function (Oxf)
Ndinganire G, Ntamukunzi G, Alagbonsi AI.   +2 more
europepmc   +1 more source