Results 81 to 90 of about 24,286 (211)

Isometric handgrip contraction increases tibialis anterior intrinsic motoneuron excitability in a dose‐dependent manner

Experimental Physiology, EarlyView.
Abstract The contribution of persistent inward currents (PICs) to motoneuron firing in the lower limb typically increases after a remote handgrip contraction, believed to result from diffuse serotonergic input increases in spinal cord. We investigated whether handgrip contraction intensity, duration and/or impulse would affect PIC estimates in tibialis
Lucas Ugliara, Lucas B. R. Orssatto, Amilton Vieira, Gabriel S. Trajano   +3 more
wiley   +1 more source

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]

, 2019
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core  

A molecular basis for selective antagonist destabilization of dopamine D3 receptor quaternary organization [PDF]

, 2017
The dopamine D3 receptor (D3R) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated that a ...
Caltabiano, Gianluigi, Jiménez-Rosés, Mireia, Marsango, Sara, Millan, Mark J., Milligan, Graeme, Pediani, John D., Ward, Richard J.   +6 more
core   +2 more sources

Role of K+ Channels in M2 Muscarinic Receptor-Mediated Inhibition of Noradrenaline Release From the Rat Stomach

Journal of Pharmacological Sciences, 2004
Previously we reported the cholinergic M2 muscarinic receptor-mediated inhibition of noradrenaline release from the rat stomach (K. Yokotani, Y. Osumi. J Pharmacol Exp Ther. 1993;264:54–60).
Kumiko Nakamura, Shoshiro Okada, Naoko Yamaguchi, Takahiro Shimizu, Keiko Yokotani, Kunihiko Yokotani   +5 more
doaj   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

Muscarinic M2 receptor promotes vasopressin synthesis in mice supraoptic nuclei [PDF]

Journal of Endocrinology, 2018
Muscarinic acetylcholine receptors have been suggested to be implicated in arginine–vasopressin secretion because intracerebroventricular muscarinic agonist administration induces arginine–vasopressin release into the circulation. Although which subtype is involved in the regulation of arginine–vasopressin secretion is unclear, M2 receptors have been ...
Hiroshi, Nagano, Yuki, Sobue, Hayato, Matsuyama, Shoichiro, Saito, Hiroki, Sakai, Firoj, Alom, Yasuyuki, Tanahashi, Toshiaki, Ishii, Toshihiro, Unno   +8 more
openaire   +2 more sources

RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents. [PDF]

, 2014
Partial agonists are used clinically to avoid overstimulation of receptor-mediated signalling, as they produce a submaximal response even at 100% receptor occupancy.
Chen, I-Shan, Furutani, Kazuharu, Inanobe, Atsushi, Kurachi, Yoshihisa   +3 more
core   +2 more sources

Inhibitory Effect of Lidocaine on Duodenal Peristalsis During Endoscopic Retrograde Cholangiopancreatography: A Multicenter, Randomized Controlled Trial (With Video)

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives Conventional antispasmodics used during endoscopic retrograde cholangiopancreatography (ERCP), such as hyoscine butylbromide and glucagon, are often contraindicated in elderly patients with comorbidities. This trial aimed to assess the efficacy of lidocaine for inhibiting duodenal peristalsis during ERCP.
Masato Suzuki, Yusuke Sekino, Kunihiro Hosono, Yusuke Kurita, Hiroki Uechi, Kento Kuzuu, Shiori Uchiyama, Kenichi Kawana, Hajime Nagase, Kensuke Kubota, Masato Yoneda, Atsushi Nakajima   +11 more
wiley   +1 more source

Benzonidazole therapy modulates interferon-γ and M2 muscarinic receptor autoantibody responses in Trypanosoma cruzi-infected children. [PDF]

PLoS ONE, 2011
OBJECTIVE: The presence of autoantibodies with adrenergic and cholinergic activity, capable of triggering neurotransmitter receptor-mediated effects, has been associated with pathogenesis in T. cruzi-infected hosts.
Romina A Cutrullis, Guillermo F Moscatelli, Samanta Moroni, Bibiana J Volta, Rita L Cardoni, Jaime M Altcheh, Ricardo S Corral, Héctor L Freilij, Patricia B Petray   +8 more
doaj   +1 more source

Facilitating interprofessional collaboration for effective care transitions of a patient with chronic obstructive pulmonary disease

Nutrition in Clinical Practice, Volume 41, Issue 2, Page 435-442, April 2026.
Abstract Transitions of care are the movement of a patient from one care setting or provider to another. Interprofessional collaboration is critical in ensuring patient safety and satisfactory health outcomes. Each time an interprofessional team transfers a patient, the team performs three important roles: representing the patient, providing patient ...
Sara Edwards, Kaitlyn Kolcun, Jeanie Bochenek, Emily Buatois, Monica Robinson, Erin Thomas, Matthew Curtis, Catherine Hechmer, Tracy Taylor, Sheela Thomas   +9 more
wiley   +1 more source