Muscarinic receptor M3 activation promotes fibrocytes contraction
Frontiers in Pharmacology, 2022 Fibrocytes are monocyte-derived cells able to differentiate into myofibroblasts-like cells. We have previously shown that they are increased in the bronchi of Chronic Obstructive Pulmonary Disease (COPD) patients and associated to worse lung function ...
Pauline Henrot +19 more
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Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq
Communications BiologyMuscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets due to their involvement in physiopathological processes.
Donghee Ham +4 more
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A New Era of Muscarinic Acetylcholine Receptor Modulators in Neurological Diseases, Cancer and Drug Abuse [PDF]
PharmaceuticalsThe cholinergic pathways in the central nervous system (CNS) play a pivotal role in different cognitive functions of the brain, such as memory and learning.
Helena Tsimpili, Grigoris Zoidis
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Efficacy and Safety of DA-8010, a Novel M3 Antagonist, in Patients With Overactive Bladder: A Randomized, Double-Blind Phase 2 Study [PDF]
International Neurourology Journal, 2022 Purpose DA-8010 is a novel muscarinic M3 receptor antagonist with significant selectivity for bladder over salivary gland in preclinical studies. We evaluated the clinical efficacy and safety of DA-8010 in overactive bladder (OAB) patients.
Hee Seo Son +12 more
doaj +1 more source
The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation
Journal of Investigative Dermatology, 2022 The M3 muscarinic acetylcholine receptor is predominantly expressed in the basal epidermal layer where it mediates the effects of the autocrine/paracrine cytotransmitter acetylcholine. Patients with the autoimmune blistering disease pemphigus develop autoantibodies to M3 muscarinic acetylcholine receptor and show alterations in keratinocyte adhesion ...
Junyan Duan +6 more
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Regulation of the Muscarinic M3 Receptor by Myocardin-Related Transcription Factors
Frontiers in Physiology, 2021 Myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MRTFA, and MRTF-B/MRTFB) are co-factors of serum response factor (SRF) that activate the smooth muscle cell (SMC) gene program and that play roles in cardiovascular development and ...
Li Liu +8 more
doaj +1 more source
Physiological Significance of Endothelial M3 Muscarinic Receptors During Exercise. [PDF]
Circ ResAckland GL +12 more
europepmc +2 more sources
Inhibition of m3 muscarinic acetylcholine receptors by local anaesthetics [PDF]
British Journal of Pharmacology, 2001 Muscarinic m1 receptors are inhibited by local anaesthetics (LA) at nM concentrations. To elucidate in more detail the site(s) of LA interaction, we compared these findings with LA effects on m3 muscarinic receptors. We expressed receptors in Xenopus oocytes.
Manuela De Klaver +9 more
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Expression of muscarinic acetylcholine receptors M3 and M5 in osteoporosis [PDF]
Medical Science Monitor, 2014 Cholinergic signaling via muscarinic acetylcholine receptors (mAChR) is known to influence various physiological functions. In bone, M3 mAChR and M5 mAChR were identified on the membrane of osteoblast-like cells. M3 mAChR seems to be particularly relevant for bone physiology, as signaling via this receptor was reported to increase bone formation and ...
Christian Heiss +3 more
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Signalling of the M3-muscarinic receptor to the anti-apoptotic pathway [PDF]
Biochemical Journal, 2004 The process of programmed cell death (or apoptosis) occurs widely in tissue maintenance and embryonic development, and is under tight regulatory control. It is now clear that one of the important regulators of apoptosis are G-protein-coupled receptors.
Budd, DC, Spragg, EJ, Ridd, K, Tobin, AB
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