Results 141 to 150 of about 39,843 (183)
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Functional expression of rat M5 muscarinic acetylcholine receptor in yeast
Biochemical and Biophysical Research Communications, 1992We have produced the rat M5 muscarinic acetylcholine receptor, an integral membrane protein, in the yeast Saccharomyces cerevisiae. This was achieved by placing an M5 gene in the yeast vector under the control of the yeast alpha-factor promoter and leader sequence.
Huang, Hao-Jen +3 more
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The ontogeny of m1–m5 muscarinic receptor subtypes in rat forebrain
Developmental Brain Research, 1992The ontogeny of muscarinic receptor subtypes in rat forebrain has been determined utilizing a panel of antisera recognizing unique epitopes of the m1-m5 receptor proteins. Total receptor density in forebrain, as measured by the non-selective antagonist, [3H]quinuclidinyl benzilate (QNB), was found to increase from 507 fmol/mg in neonates (3.5 days) to ...
S J, Wall +4 more
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Increased drinking in mutant mice with truncated M5 muscarinic receptor genes
Pharmacology Biochemistry and Behavior, 2002The rarest and least understood of the muscarinic receptors is the M5 subtype. Recombinant methods were used to create mutant mice with a deletion in the third intracellular loop of the M5 receptor gene. Salivation induced by the nonselective muscarinic agonist pilocarpine (1 mg/kg s.c.) was reduced in homozygous mutants from 15 to 60 min after ...
Junichi, Takeuchi +9 more
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Molecular Pharmacology, 1994
Current models of the three-dimensional structures of muscarinic acetylcholine receptors and other G protein-coupled receptors are based primarily on high-resolution electron diffraction data obtained with bacteriorhodopsin, the molecular structure of which is characterized by the presence of seven alpha-helical transmembrane domains (TM I-VII ...
Z, Pittel, J, Wess
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Current models of the three-dimensional structures of muscarinic acetylcholine receptors and other G protein-coupled receptors are based primarily on high-resolution electron diffraction data obtained with bacteriorhodopsin, the molecular structure of which is characterized by the presence of seven alpha-helical transmembrane domains (TM I-VII ...
Z, Pittel, J, Wess
openaire +2 more sources
The Muscarinic Acetylcholine Receptor M5: Therapeutic Implications and Allosteric Modulation.
ACS Chemical Neuroscience, 2018The muscarinic acetylcholine receptor (mAChR) subtype 5 (M5) was the most recent mAChR to be cloned and has since emerged as a potential therapeutic target for a number of indications.
Aaron M. Bender +2 more
semanticscholar +1 more source
Journal of Cellular Biochemistry, 2022
Ovarian cancer is the fifth leading cause of cancer‐related deaths in females. Many ovarian tumor cell lines express muscarinic receptors (mAChRs), and their expression is correlated with reduced survival of patients. We have characterized the expression
Marilena Taggi +7 more
semanticscholar +1 more source
Ovarian cancer is the fifth leading cause of cancer‐related deaths in females. Many ovarian tumor cell lines express muscarinic receptors (mAChRs), and their expression is correlated with reduced survival of patients. We have characterized the expression
Marilena Taggi +7 more
semanticscholar +1 more source
Journal of Neonatal Surgery
The effectiveness of existing treatments for depression, a complicated mental health condition that affects people all over the world, is limited. The ability of the muscarinic acetylcholine receptor subtype M5 (M5 mAChR) to modulate dopaminergic and ...
Smita Sunil Sawalwade +3 more
semanticscholar +1 more source
The effectiveness of existing treatments for depression, a complicated mental health condition that affects people all over the world, is limited. The ability of the muscarinic acetylcholine receptor subtype M5 (M5 mAChR) to modulate dopaminergic and ...
Smita Sunil Sawalwade +3 more
semanticscholar +1 more source
Persistent Binding and Functional Antagonism by Xanomeline at the Muscarinic M5 Receptor
The Journal of Pharmacology and Experimental Therapeutics, 2005Xanomeline is a functionally selective M1/M4 muscarinic acetylcholine receptor agonist. We have previously identified a novel mode of interaction of this ligand with the muscarinic M1 receptor that involves persistent binding and activation of the receptor after extensive washout.
Marianne K O, Grant, Esam E, El-Fakahany
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Physical Chemistry, Chemical Physics - PCCP, 2022
Structures of muscarinic acetylcholine receptors illustrate the strikingly high degree of homology of the residues among isoforms, thus leading to difficulty in achieving subtype selectivity when targeting these receptors and causing undesired side ...
Lu Chen +8 more
semanticscholar +1 more source
Structures of muscarinic acetylcholine receptors illustrate the strikingly high degree of homology of the residues among isoforms, thus leading to difficulty in achieving subtype selectivity when targeting these receptors and causing undesired side ...
Lu Chen +8 more
semanticscholar +1 more source
Linkage of M5 Muscarinic and α7-Nicotinic Receptor Genes on 15q13 to Schizophrenia
Neuropsychobiology, 2004Most antipsychotic drugs act on the forebrain by blocking dopamine receptors. In rodents, the M5 muscarinic receptor (CHRM5) is important for prolonged dopamine release. We typed polymorphisms in CHRM5 and α7-nicotinic receptor (CHRNA7) genes on 15q13 in 82 Canadian families having at least 1 schizophrenic patient.
De Luca V +5 more
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