Results 51 to 60 of about 39,843 (183)

Autoantibodies against M5-muscarinic and beta1-adrenergic receptors in periodontitis patients

Aging, 2020
Autoantibodies against muscarinic and beta1-adrenergic receptors are considered a potential cause and/or risk factor for chronic heart failure. Association of periodontitis with such autoantibodies and with impaired heart function has been observed in patients exposed to endemic Chagas' disease, which triggers by itself cardiomyopathy and receptor ...
Scherbaum, Isabel, Heidecke, Harald, Bunte, Kübra, Peters, Ulrike, Beikler, Thomas, Boege, Fritz   +5 more
openaire   +2 more sources

Glial cells in the heart: Implications for their roles in health and disease

The Journal of Physiology, Volume 604, Issue 4, Page 1531-1546, 15 February 2026.
Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya, Rimma Dugarova, Shefeeq M. Theparambil   +2 more
wiley   +1 more source

Physiological functions of the cholinergic system in immune cells

Journal of Pharmacological Sciences, 2017
T and B cells, macrophages and dendritic cells (DCs) all express most of the components necessary for a functional cholinergic system. This includes choline acetyltransferase (ChAT), muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and ...
Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashima   +6 more
doaj   +1 more source

Alpha‐Ketoglutarate Regulates Intestinal Motility and Health by OXGR1 in Nitrergic Neuron of Enteric Nervous System

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Intestinal health could be affected by intestinal motility, which is controlled by the enteric nervous system. In this study, we found that α‐ketoglutarate (AKG) inhibits intestinal motility and improves intestinal permeability, accompanied by an increased count of intestinal flora.
Guli Xu, Jingjing Zhou, Pingwen Xu, Ishwari Gyawali, Chang Xu, Jinping Yang, Zewei Ma, Dan Du, Qingyan Jiang, Gang Shu   +9 more
wiley   +1 more source

Chotosan, a Kampo Formula, Ameliorates Chronic Cerebral Hypoperfusion-Induced Deficits in Object Recognition Behaviors and Central Cholinergic Systems in Mice

Journal of Pharmacological Sciences, 2007
We previously demonstrated that the Kampo formula chotosan (CTS) ameliorated spatial cognitive impairment via central cholinergic systems in a chronic cerebral hypoperfusion (P2VO) mouse model.
Qi Zhao, Yukihisa Murakami, Michihisa Tohda, Ryosuke Obi, Yutaka Shimada, Kinzo Matsumoto   +5 more
doaj   +1 more source

Regulation of cell spreading during differentiation in the muscarinic M5 receptor tumor-suppressor model [PDF]

International Journal of Cancer, 1997
Activation of the muscarinic receptor in Chinese hamster ovary (CHO) cells results in a reversal of the malignant phenotype for which spreading into a bipolar, fibroblastic morphology is a marker. The process of morphologic change requires multiple events, including alterations in adhesions to substrates and cytoskeletal re-arrangement. In this report,
J R, Spoonster, L, Masiero, S A, Savage, J, Probst, E C, Kohn   +4 more
openaire   +2 more sources

Spirocyclic Diamine Scaffolds for Medicinal Chemistry

Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.
Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel, Alejandro Flores, Maedeh Darsaraee, Jean‐Louis Reymond   +3 more
wiley   +1 more source

Bis-Quinolinium Cyclophane Blockers of SK Potassium Channels Are Antagonists of M3 Muscarinic Acetylcholine Receptors

Frontiers in Pharmacology, 2020
Dequalinium is used as an antimicrobial compound for oral health and other microbial infections. Derivatives of dequalinium, the bis-quinolinium cyclophanes UCL 1684 and UCL 1848, are high affinity SK potassium channel antagonists.
Vladislav Bugay, Derek J. Wallace, Bin Wang, Irving Salinas, Adriana Paola Chapparo, Hudson Ryan Smith, Peter Herbert Dube, Edward G. Brooks, Edward G. Brooks, Kelly Ann Berg, Robert Brenner   +10 more
doaj   +1 more source

Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection

Pharmacological Research
Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova, Ken Mackie, Alex Straiker   +2 more
doaj   +1 more source

Expression and Function of the Cholinergic System in Immune Cells

Frontiers in Immunology, 2017
T and B cells express most cholinergic system components—e.g., acetylcholine (ACh), choline acetyltransferase (ChAT), acetylcholinesterase, and both muscarinic and nicotinic ACh receptors (mAChRs and nAChRs, respectively).
Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashima   +6 more
doaj   +1 more source