Results 211 to 220 of about 53,843 (262)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Sex-aware genome-wide assessment of de novo variants in autism across coding and noncoding regions. [PDF]

Hum Genomics
Turner TN.
europepmc   +1 more source

Disrupting melanin transfer: innovative strategy for anti-pigmentation drug discovery. [PDF]

J Enzyme Inhib Med Chem
Niu X, Zhi J, Feng M, Wang S, Feng X, Jiang X, Chen W, Bai R.   +7 more
europepmc   +1 more source

Effect of Electroacupuncture on Intestinal Mucosal Barrier in IBS-D Rats: Analysis Based on RNA-seq. [PDF]

Comb Chem High Throughput Screen
Ruan J, Zhu J, Li K, Wang Z, Wang T, Han X, Li X, Fang Y, Song X, Chu H.   +9 more
europepmc   +1 more source

PAR for the course - protease-activated receptor 4 protects the brain from hemorrhage. [PDF]

Res Pract Thromb Haemost
Andrianova I, Denorme F.
europepmc   +1 more source

Non-canonical cell death in neurodegeneration: emerging mechanisms and therapeutic Frontiers. [PDF]

Apoptosis
Ercin N, Besli N, Beker M, Celik U.
europepmc   +1 more source

SARS-CoV-2 Omicron variant spike protein maintains the ability to bind and activate human platelets: Comparison with the wild-type. [PDF]

Sci Rep
Kusudo E, Kawamoto S, Matsumoto T, Egi M.   +3 more
europepmc   +1 more source

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Cardiovascular Responses Mediated by Protease-Activated Receptor-2 (PAR-2) and Thrombin Receptor (PAR-1) are Distinguished in Mice Deficient in PAR-2 or PAR-1

Journal of Pharmacology and Experimental Therapeutics, 1999
We developed mice deficient in protease-activated receptor-2 (PAR-2) or PAR-1 to explore the pathophysiological functions of these receptors. In this report, we evaluated mean arterial pressure and heart rate (HR) changes in response to PAR-1 or PAR-2 activation in anesthetized wild-type (WT), PAR-1-deficient (PAR-1(-/-)), and PAR-2-deficient (PAR-2(-/-
Bruce P Damiano, Wai-Ping Fung-Leung, Richard D Ye   +2 more
exaly   +3 more sources