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Expression of protease activated receptor-2 (PAR-2) in gastric cancer
Journal of Surgical Oncology, 2006Recently, the four-kind cloning of the protease-activated receptor (PAR) had been carried out. PAR-2 is activated by trypsin and it is supposed that PAR-2 participated in proliferation of the endothelial cell or in neovascularization. We considered whether the expression of PAR-2 has relevance to progression in gastric cancer.Immunohistochemical study ...
Daisuke Fujimoto +2 more
exaly +3 more sources
The Journal of Pharmacology and Experimental Therapeutics, 2005
Protease-activated receptor-2 (PAR-2) plays an extensive role in the regulation of digestive exocrine secretion. The present study examined whether PAR-2-related peptides could modulate tear secretion in rats and analyzed the underlying mechanisms. SLIGRL-NH(2), a PAR-2-activating peptide (PAR-2-AP) derived from mouse/rat PAR-2, when administered i.v ...
Hiroyuki, Nishikawa +9 more
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Protease-activated receptor-2 (PAR-2) plays an extensive role in the regulation of digestive exocrine secretion. The present study examined whether PAR-2-related peptides could modulate tear secretion in rats and analyzed the underlying mechanisms. SLIGRL-NH(2), a PAR-2-activating peptide (PAR-2-AP) derived from mouse/rat PAR-2, when administered i.v ...
Hiroyuki, Nishikawa +9 more
openaire +2 more sources
Protease-activated receptor-2 (PAR-2) in cervical cancer proliferation
Gynecologic Oncology, 2008Protease-activated receptor-2 (PAR-2) is a G-protein-coupled receptor that is cleaved and activated by trypsin and tryptase. There is evidence that PAR-2 contributes to tumor progression in stomach, colon, pancreas, prostate and breast cancer patients. However, the role of PAR-2 in cervical cancer is still unknown. The aim of this work was to study the
Pedro Ernesto, Sánchez-Hernández +6 more
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Expression of protease-activated-receptor 2 (PAR-2) in human esophageal mucosa
Scandinavian Journal of Gastroenterology, 2009The role of duodenal reflux in gastroesophageal reflux disease (GERD) containing bile salts and pancreatic enzymes (with special attention to trypsin) is still under discussion. Proteinase-activated receptors (PARs) are a novel family and PAR-2 is a unique member of this family because it is activated by trypsin.
Kamuran, Inci +3 more
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Protease-activated receptor-2 (PAR-2): A potential new target in arthritis
Drugs of the Future, 2008Protease-activated receptors (PARs) are a novel family of seven-transmembrane G-protein-coupled receptors. The unique feature of this family is that activation is initiated by cleavage of the N-terminus by serine or other proteases, thereby unmasking a tethered ligand that then interacts with the receptor, leading to activation.
Ferrell, W.R. +2 more
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The Role of Proteinase Activated Receptor-2 (PAR-2) Activation in the Airways
2022Allergens possessing serine proteinase activity like house dust mite (HDM) and cockroach can activate proteinase-activated receptor-2 (PAR-2), a pro-inflammatory G-coupled receptor. Par-2 -/- mice develop attenuated airway inflammation compared to WT mice.
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Cell and Tissue Research, 2014
The protease-activated receptors are a group of unique G protein-coupled receptors, including PAR-1, PAR-2, PAR-3 and PAR-4. PAR-2 is activated by multiple trypsin-like serine proteases, including trypsin, tryptase and coagulation proteases. The clusters of phosphorylation sites in the PAR-2 carboxyl tail are suggested to be important for the binding ...
Zhihui, Zhu +4 more
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The protease-activated receptors are a group of unique G protein-coupled receptors, including PAR-1, PAR-2, PAR-3 and PAR-4. PAR-2 is activated by multiple trypsin-like serine proteases, including trypsin, tryptase and coagulation proteases. The clusters of phosphorylation sites in the PAR-2 carboxyl tail are suggested to be important for the binding ...
Zhihui, Zhu +4 more
openaire +2 more sources
PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2003Protease-activated receptor-2 (PAR-2) is a G protein-coupled receptor and is expressed throughout the gut. It is well known that PAR-2 participates in the regulation of gastrointestinal motility; however, the results are inconsistent. The present study investigated the effect and mechanism of PAR-2 activation on murine small intestinal smooth muscle ...
Aiping, Zhao, Terez, Shea-Donohue
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Scandinavian Journal of Gastroenterology, 2007
Helicobacter pylori infection is considered to be an important factor in the development of gastric cancer, while duodenogastroesophageal reflux is claimed to be the main cause of development of esophageal adenocarcinoma. A pronounced activation of PAR-2 receptors may be a common denominator in triggering the development of these cancers, and possibly ...
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Helicobacter pylori infection is considered to be an important factor in the development of gastric cancer, while duodenogastroesophageal reflux is claimed to be the main cause of development of esophageal adenocarcinoma. A pronounced activation of PAR-2 receptors may be a common denominator in triggering the development of these cancers, and possibly ...
openaire +2 more sources
Control of ion transport in mammalian airways by protease activated receptors type 2 (PAR‐2)
The FASEB Journal, 2005ABSTRACT Protease‐activated receptors (PARs) are widely distributed in human airways. They couple to G‐proteins and are activated after proteolytic cleavage of the N terminus of the receptor. Evidence is growing that PAR subtype 2 plays a pivotal role in inflammatory airway diseases, such as allergic asthma or ...
Kunzelmann, Karl +6 more
openaire +5 more sources