Results 231 to 240 of about 53,843 (262)

Receptor-activating peptides distinguish thrombin receptor (PAR-1) and protease activated receptor 2 (PAR-2) mediated hemodynamic responses in vivo

Canadian Journal of Physiology and Pharmacology, 1998
Vascular expression and cellular functions of the thrombin receptor (PAR-1) and protease activated receptor 2 (PAR-2) suggest similar but distinct vascular regulatory roles. The vascular actions of PAR-1 and PAR-2 in vivo were differentiated by monitoring mean arterial pressure (MAP) and heart rate (HR) of anesthetized mice in response to intravenous ...
W M, Cheung, P, Andrade-Gordon, C K, Derian, B P, Damiano   +3 more
openaire   +2 more sources

Proteinase-activated receptor 2 (PAR-2) in gastrointestinal and pancreatic pathophysiology, inflammation and neoplasia

Scandinavian Journal of Gastroenterology, 2008
Of all the body systems, the gastrointestinal (GI) tract is the most exposed to proteinases. Proteolytic activity must thus be tightly regulated in the face of diverse environmental challenges, because unrestrained or excessive proteolysis leads to pathological GI conditions. The protease-activated receptor-2 (PAR-2) is expressed in numerous cell types
openaire   +2 more sources

Regulation of Proteinase-Activated Receptor-2 (PAR-2) in Airway Epithelium

2018
Proteinase-activated receptor-2 (PAR-2), a pro-inflammatory G-coupled receptor, is activated by exogenous or endogenous serine proteinases. PAR-2 is involved in the pathogenesis of inflammatory diseases including asthma. PAR-2 activation on airway epithelial cells (AECs) results in the release of inflammatory mediators that play an important role in ...
openaire   +1 more source

PAR-2 agonists activate trigeminal nociceptors and induce functional competence in the delta opioid receptor

Pain, 2006
The role of protease activated receptor-2 (PAR-2) activation in trigeminal nociception and in induction of functional competence in the delta opioid receptor (DOR) is not known. In this study, we evaluated whether agonists of PAR-2 activate the capsaicin-sensitive subclass of trigeminal nociceptors in a PLC-PKC-dependent manner and induce functional ...
Amol M, Patwardhan, Anibal, Diogenes, Kelly A, Berg, Jill C, Fehrenbacher, William P, Clarke, Armen N, Akopian, Kenneth M, Hargreaves   +6 more
openaire   +2 more sources

Protease-activated receptor-2 (PAR-2) in the pathogenesis of osteoarthritis

2011
Paper 125. Osteoarthritis (OA) is a global clinical challenge for which no effective disease-modifying agents currently exist. Proteinase activated receptor-2 (PAR-2) is a cell surface receptor activated by proteolytic cleavage, revealing a tethered ligand which binds to extracellular loop 2 resulting in intracellular signalling.
Ferrell, William R., Kelso, Elizabeth B., Lockhart, John C., Burns, Elizabeth, Plevin, Robin, McInnes, Iain B.   +5 more
openaire   +2 more sources

THE EFFECTS OF TRYPSIN ON PANCREATIC PAR-2 RECEPTORS

Pancreas, 2006
P??ter Hegyi, B??la ??zsv??ri, Imre Ign??th, Vikt??ria Venglovecz, Zolt??n Rakonczay, Tam??s Tak??cs, Katalin Borka, Zsuzsa Schaff, Gyula J. Papp, Andr??s T??th, Andr??s Varr??, Mikl??s Sahin-T??th, J??nos Lonovics   +12 more
openaire   +1 more source

Par-2 Receptors Stimulate Sodium Transport in Collecting Duct Cells

Journal of Investigative Medicine, 2001
K S Hering-Smith, M C Carmichael, F R Schiro, L L Hamm   +3 more
openaire   +1 more source

Expression of protease-activated receptor-2 (PAR-2) in Barrett's esophagus.

Zeitschrift für Gastroenterologie, 2009
A Rosztóczy, I Németh, F Izbéki, K Vadászi, R Róka, K Gecse, L Tiszlavicz, T Wittmann   +7 more
openaire   +1 more source

Principles of PAR polarity in Caenorhabditis elegans embryos

Nature Reviews Molecular Cell Biology, 2013
Carsten Hoege, Anthony A Hyman, Hyman Anthony A   +2 more
exaly  

The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localization

EMBO Journal, 2007
Mingjie Zhang
exaly