Results 241 to 250 of about 77,428 (274)

Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 expression in human lung adenocarcinoma.

Chest, 2010
In many primary tumors, parathyroid hormone-related peptide (PTHrP) and PTHrP type 1 receptor (PTH1R) are coexpressed, supporting the possibility that PTHrP/PTH1R system can mediate important signals for tumor progression through paracrine/autocrine mechanisms.
G. Monego, L. Lauriola, S. Ramella, R. D'Angelillo, P. Lanza, P. Granone, F. Ranelletti   +6 more
semanticscholar   +5 more sources

β-Arrestin-biased signaling of PTH analogs of the type 1 parathyroid hormone receptor.

Cellular Signalling, 2013
Parathyroid hormone (PTH) is an anabolic agent that mediates bone formation through activation of the Gα(s)-, Gα(q)- and β-arrestin-coupled parathyroid hormone receptor type 1 (PTH1R). Pharmacological evidence based on the effect of PTH(7-34), a PTH derivative that is said to preferentially activate β-arrestin signaling through PTH1R, suggests that ...
Miranda M. C. van der Lee, Folkert Verkaar, J. Wat, Jody van Offenbeek, Martijn Timmerman, Lonneke Voorneveld, Lambertus H. C. J. van Lith, G. Zaman   +7 more
semanticscholar   +3 more sources

Type 1 receptor parathyroid hormone (PTH1R) influences breast cancer cell proliferation and apoptosis induced by high levels of glucose

Medical Oncology, 2012
Increased breast cancer incidence parallels the increase in cases of type 2 diabetes. We investigated the effect of type 1 receptor parathyroid hormone (PTH1R) expression on viability and apoptosis of breast cancer cells exposed to high levels of glucose.
Huasheng Liang, Yu-hua Zhong, Yu Huang, Genben Chen   +3 more
semanticscholar   +3 more sources

Nuclear localization of the type 1 parathyroid hormone/parathyroid hormone-related peptide receptor in MC3T3-E1 cells: association with serum-induced cell proliferation.

Bone, 2000
We have recently demonstrated that the receptor for parathyroid hormone (PTH) and PTH-related peptide (PTHrP), PTHR, can be localized to the nucleus of cells within the liver, kidney, uterus, gut, and ovary of the rat. We set out to determine the localization of the PTHR in cultured osteoblast-like cells.
P. Watson, L. Fraher, B. Natale, M. Kisiel, G. Hendy, A. Hodsman   +5 more
semanticscholar   +3 more sources

Human parathyroid hormone-related protein and human parathyroid hormone receptor type 1 are expressed in human medulloblastomas and regulate cell proliferation and apoptosis in medulloblastoma-derived cell lines

Acta Neuropathologica, 2007
Human parathyroid hormone-related protein (hPTHrP), identified in patients with paraneoplastic hypercalcemia and expressed by different cell types during development and adult life, plays important roles in many human neoplasms. Immunohistochemical and RT-PCR analyses of hPTHrP and human parathyroid hormone receptor type 1 (PTHR-1) in primary ...
M. Gessi, G. Monego, G. Calviello, P. Lanza, F. Giangaspero, A. Silvestrini, L. Lauriola, F. Ranelletti   +7 more
semanticscholar   +4 more sources

Chapter 56 – Parathyroid Hormone and the Parathyroid Hormone Receptor Type 1 in the Regulation of Calcium and Phosphate Homeostasis and Bone Metabolism

, 2016
T. Gardella, H. Jüppner, E. Brown, H. Kronenberg, J. Potts   +4 more
semanticscholar   +2 more sources

Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein

, 2019
The parathyroid hormone receptor-1 (PTH1R) is a class B G protein–coupled receptor central to calcium homeostasis and a therapeutic target for osteoporosis and hypoparathyroidism. Here we report the cryo–electron microscopy structure of human PTH1R bound
Lihua Zhao, S. Ma, Ieva Sutkeviciute, D.-D. Shen, X. E. Zhou, P. Waal, Chuankui Li, Yanyong Kang, Lisa J. Clark, F. Jean-Alphonse, A. White, Dongyong Yang, A. Dai, X. Cai, Jianmin Chen, Chun Xing Li, Y. Jiang, Tomoyuki Watanabe, T. Gardella, K. Melcher, Ming-Wei Wang, J. Vilardaga, H. E. Xu, Yan Zhang   +23 more
semanticscholar   +1 more source

Unraveling the Interplay of Extracellular Domain Conformational Changes and Parathyroid Hormone Type 1 Receptor Activation in Class B1 G Protein-Coupled Receptors: Integrating Enhanced Sampling Molecular Dynamics Simulations and Markov State Models.

ACS Chemical Neuroscience
Parathyroid hormone (PTH) type 1 receptor (PTH1R), as a typical class B1 G protein-coupled receptor (GPCR), is responsible for regulating bone turnover and maintaining calcium homeostasis, and its dysregulation has been implicated in the development of ...
Mengrong Li, Xiaoxiao Zhang, Shu Li, Jingjing Guo   +3 more
semanticscholar   +1 more source

Measurement of agonist and antagonist ligand-binding parameters at the human parathyroid hormone type 1 receptor: evaluation of receptor states and modulation by guanine nucleotide.

Journal of Pharmacology and Experimental Therapeutics, 1999
Determination of ligand-binding constants for parathyroid hormone (PTH) receptors has been hampered by a lack of suitable experimental systems and mechanistic models for data analysis.
S. Hoare, G. de Vries, T. Usdin
semanticscholar   +1 more source

Molecular Mechanisms of Parathyroid Hormone Type 1 Receptor Signaling

2020
Ieva Sutkeviciute, Lisa J. Clark, Jean-Pierre Vilardaga   +2 more
openaire   +1 more source