Results 1 to 10 of about 39,335 (289)
Receptor oligomerization: from early evidence to current understanding in class B GPCRs [PDF]
Frontiers in Endocrinology, 2013 Dimerization or oligomerization of G protein-coupled receptors (GPCRs) are known to modulate receptor functions in terms of ontogeny, ligand-oriented regulation, pharmacological diversity, signal transduction and internalization.
Stephanie Yuen Lam Ng +2 more
doaj +3 more sources
Acta Biomedica Scientifica, 2021 Parathyroid hormone receptors PTH1R and PTH2R are poorly studied in the pathology of the vertebral column and may be involved in both ectopic ossification of the vertebral ligaments and fibrous growth of the extracellular matrix, as well as in other ...
L. V. Rodionova +2 more
doaj +1 more source
The Unicellular State as a Point Source in a Quantum Biological System. [PDF]
, 2016 A point source is the central and most important point or place for any group of cohering phenomena. Evolutionary development presumes that biological processes are sequentially linked, but neither directed from, nor centralized within, any specific ...
Miller, William B, Torday, John S
core +9 more sources
Molecular Mechanisms of Parathyroid Disorders in Chronic Kidney Disease
Metabolites, 2022 Secondary hyperparathyroidism (SHP) is a common complication of chronic kidney disease (CKD) that induces morbidity and mortality in patients. How CKD stimulates the parathyroid to increase parathyroid hormone (PTH) secretion, gene expression and cell ...
Alia Hassan +6 more
doaj +1 more source
Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase
Journal of Pharmacological Sciences, 2021 Proteins interacting with G protein-coupled receptors (GPCRs) can modulate signal transduction of these receptors. However, the regulatory mechanisms of the interacting proteins are diverse and largely unknown.
Masaki Saito +5 more
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Frontiers in Endocrinology, 2022 Hypercalcemia is a common complication in cancer patients Mainly caused by Parathyroid hormone-related protein (PTHrP) secretion and metastasis. Calcitriol secretion is a rare source of hypercalcemia in solid tumors, especially in gastrointestinal ...
Yiraldine Herrera-Martínez +22 more
doaj +1 more source
Secretion of parathyroid hormone may be coupled to insulin secretion in humans
Endocrine Connections, 2020 Objective: Parathyroid hormone (PTH) is a key hormone in regulation of calcium homeostasis and its secretion is regulated by calcium. Secretion of PTH is attenuated during intake of nutrients, but the underlying mechanism(s) are unknown.
Marie Reeberg Sass +12 more
doaj +1 more source
Bisphosphonate-resistant hypercalcemia in a rare case of paraneoplastic PTH secretion
Journal of Clinical and Translational Endocrinology Case Reports, 2022 Background/objective: To report a rare case of ectopic parathyroid hormone (PTH) secretion from poorly-differentiated adenocarcinoma and the lessons learned in management.
Anna Y. Groysman +4 more
doaj +1 more source
Медицинский совет, 2022 Currently, the incidence and prevalence of chronic kidney disease (CKD) are increasing annually worldwide, and clinical data show that CKD patients commonly experience relative vitamin D insufficiency or deficiency.
L. V. Egshatyan
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Loss of receptor activity-modifying protein 2 in mice causes placental dysfunction and alters PTH1R regulation. [PDF]
PLoS ONE, 2017 Receptor activity-modifying protein 2 (Ramp2) is a single-pass transmembrane protein that heterodimerizes with several family B G-protein coupled receptors to alter their function.
Mahita Kadmiel +4 more
doaj +1 more source