Results 21 to 30 of about 21,293 (242)
Clinical insight into hypercalcemia in children
Endokrynologia PolskaPlasma calcium levels are regulated by many factors, including the levels of calcium-sensitive receptors, parathyroid hormone, parathyroid hormone receptors, vitamin D, vitamin D receptors, and other proteins.
Huseyin Anıl Korkmaz
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What do we know about lithium associated hypercalcemia?
European Psychiatry, 2023 Introduction Lithium associated with hypercalcemia may mimic a psychiatric condition and be confused for a relapse of bipolar disorder. The etiology seems to be due to a reduced sensitivity of the parathyroid cells to calcium, altering the parathyroid ...
N. Laherrán Cantera +4 more
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Purification and Characterization of a Receptor for Human Parathyroid Hormone and Parathyroid Hormone-related Peptide [PDF]
Journal of Biological Chemistry, 2002 The human parathyroid hormone (PTH) receptor (hPTH1R), containing a 9-amino acid sequence of rhodopsin at its C terminus, was transiently expressed in COS-7 cells and solubilized with 0.25% n-dodecyl maltoside. Approximately 18 microg of hPTH1R were purified to homogeneity per mg of crude membranes by single-step affinity chromatography using 1D4, a ...
Masako, Shimada +5 more
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International Journal of Nephrology, 2012 Secondary hyperparathyroidism (s-HPT) in uremia is characterized by decreased expression in the parathyroids of calcium sensing (CaR) and vitamin D receptors (VDR).
Jacob Hofman-Bang +3 more
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Megalin Antagonizes Activation of the Parathyroid Hormone Receptor [PDF]
Journal of Biological Chemistry, 1999 Parathyroid hormone (PTH) is predominantly cleared from the circulation by glomerular filtration and degradation in the renal proximal tubules. Here, we demonstrate that megalin, a multifunctional endocytic receptor in the proximal tubular epithelium, mediates the uptake and degradation of PTH.
Hilpert, J +9 more
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FGF23 Actions on Target Tissues—With and Without Klotho
Frontiers in Endocrinology, 2018 Fibroblast growth factor (FGF) 23 is a phosphaturic hormone whose physiologic actions on target tissues are mediated by FGF receptors (FGFR) and klotho, which functions as a co-receptor that increases the binding affinity of FGF23 for FGFRs.
Beatrice Richter, Christian Faul
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Advances in Difference Equations, 2017 Calcium signaling plays important physiological roles which range widely from activation of muscle, synaptic transmission, cell movement, fertilization, growth in the cell population, learning process and retention of memory, to saliva secretion. Calcium
Chontita Rattanakul, Yongwimon Lenbury
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Changes in Bone Metabolism and Structure in Primary Hyperparathyroidism
Acta Medica Bulgarica, 2020 Parathyroid hormone (PTH) is a key regulator of bone turnover. Depending on the duration of action, the hormone causes catabolic and anabolic effects by binding with specific receptors (PTHR1) in the bone.
Yankova I., Shinkov A., Kovatcheva R.
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Frontiers in Endocrinology, 2023 IntroductionNaringenin, a peroxisome proliferator-activated receptor (PPAR) activator found in citrus fruits, upregulates markers of thermogenesis and insulin sensitivity in human adipose tissue.
Ann A. Coulter +8 more
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Parathyroid hormone acts as a pharmacological chaperone on the parathyroid hormone receptor
The FASEB Journal, 2008 Parathyroid hormone receptor (PTH1R) belongs to class B G‐protein‐coupled receptors and is the major regulator of extracellular calcium homeostasis. Binding of the native ligand parathyroid hormone (PTH) or biologically active peptide fragments of PTH to the receptor lead to the activation of Gs and Gq/G11 pathways with subsequent stimulation of ...
Christoph Klenk, Martin J. Lohse
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