Results 41 to 50 of about 21,293 (242)

Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes. [PDF]

PLoS ONE, 2014
Inositol 1,4,5-trisphosphate (IP3) evokes release of Ca2+ from the endoplasmic reticulum (ER), but the resulting Ca2+ signals are shaped by interactions with additional intracellular organelles.
Cristina I López Sanjurjo, Stephen C Tovey, Colin W Taylor   +2 more
doaj   +1 more source

Biologic and Targeted Synthetic Disease‐Modifying Antirheumatic Drugs Do Not Arrest Bone Loss in Patients With Rheumatoid Arthritis: A Long‐Term Multicenter Observational Study

Arthritis &Rheumatology, EarlyView.
Objective Osteoporosis causes fractures that further increase the disease burden of rheumatoid arthritis (RA); however, osteoporosis treatment rates remain low. Although several studies have reported that biologic or targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) can prevent or improve osteoporosis in RA, our large‐scale, real ...
Takafumi Aritomi, Koshiro Sonomoto, Shingo Nakayamada, Hiroaki Tanaka, Atsushi Nagayasu, Satoshi Kubo, Ippei Miyagawa, Ayako Yamaguchi, Naoaki Ohkubo, Yasuyuki Todoroki, Yurie Satoh‐Kanda, Masanobu Ueno, Ryuichiro Kanda, Yuya Fujita, Masashi Funada, Hidenori Sakai, Satsuki Matsunaga, Hiroaki Tanaka, Masayuki Shinojima, Hiroki Kawamura, Kazuki Takahashi, Miyabi Ando, Kazuki Haru, Yusuke Miyazaki, Kentaro Hanami, Masao Nawata, Shunsuke Fukuyo, Keisuke Nakatsuka, Mikiko Tokunaga, Kazuyoshi Saito, Yoshiya Tanaka   +30 more
wiley   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

The effect of oral vitamin D on serum level of N-terminal pro-B-type natriuretic peptide

Advanced Biomedical Research, 2014
Background: The risk of cardiovascular disease in dialysis patients is higher than the general population. Vitamin D receptors exist in myocardium inhibit cardiac hypertrophy.
Shiva Seirafian, Yalda Haghdarsaheli, Mojgan Mortazavi, Mohsen Hosseini, Firouzeh Moeinzadeh   +4 more
doaj   +1 more source

PTH1R Actions on Bone Using the cAMP/Protein Kinase A Pathway

Frontiers in Endocrinology, 2022
After the initial signaling action of parathyroid hormone (PTH) on bone was shown to be activation of adenylyl cyclase, its target was found to be cells of the osteoblast lineage, to the exclusion of osteoclasts and their precursors. This led to the view
T. John Martin
doaj   +1 more source

Gene structure, transcripts and calciotropic effects of the PTH family of peptides in Xenopus and chicken

BMC Evolutionary Biology, 2010
Background Parathyroid hormone (PTH) and PTH-related peptide (PTHrP) belong to a family of endocrine factors that share a highly conserved N-terminal region (amino acids 1-34) and play key roles in calcium homeostasis, bone formation and skeletal ...
Power Deborah M, Fuentes Juan, Gomes Ana S, Cardoso João CR, Pinheiro Pedro LC, Canário Adelino VM   +5 more
doaj   +1 more source

The Neuroendocrine Functions of the Parathyroid Hormone 2 Receptor [PDF]

Frontiers in Endocrinology, 2012
The G-protein coupled parathyroid hormone 2 receptor (PTH2R) is concentrated in endocrine and limbic regions in the forebrain. Its endogenous ligand, tuberoinfundibular peptide of 39 residues (TIP39), is synthesized in only two brain regions, within the posterior thalamus and the lateral pons.
Dobolyi, Arpád, Dimitrov, Eugene, Palkovits, Miklós, Usdin, Ted B.   +3 more
openaire   +4 more sources

The Calcium-sensing Receptor and Integrins in Cellular Differentiation and Migration

Frontiers in Physiology, 2016
The calcium-sensing receptor (CaSR) is a widely expressed homodimeric G-protein coupled receptor structurally related to the metabotropic glutamate receptors and GPRC6A.
David R Hampson, Sujeenthar eTharmalingam   +1 more
doaj   +1 more source

PTHrP Overexpression Increases Sensitivity of Breast Cancer Cells to Apo2L/TRAIL. [PDF]

PLoS ONE, 2013
Parathyroid hormone-related protein (PTHrP) is a key component in breast development and breast tumour biology. PTHrP has been discovered as a causative agent of hypercalcaemia of malignancy and is also one of the main factors implicated in breast cancer
Vanessa Cheung, Steve Bouralexis, Matthew T Gillespie   +2 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source