Functional characterization and evolution ofPTH/PTHrP receptors: insights from the chicken [PDF]
, 2012 The parathyroid hormone (PTH)-family consists of a group of structurally related factors that regulate calcium and bone homeostasis and are also involved in development of organs such as the heart, mammary gland and immune system.
Canario, Adelino V. M. +3 more
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Regulation of Stanniocalcin Secretion by Calcium and PTHrP in Gilthead Seabream (Sparus aurata)
Biology, 2022 Calcium balance is of paramount importance for vertebrates. In fish, the endocrine modulators of calcium homeostasis include the stanniocalcin (STC), and some members of the parathyroid hormone (PTH) family, such as the PTH-related protein (PTHrP ...
Ignacio Ruiz-Jarabo +2 more
doaj +1 more source
The Neuroendocrine Functions of the Parathyroid Hormone 2 Receptor [PDF]
Frontiers in Endocrinology, 2012 The G-protein coupled parathyroid hormone 2 receptor (PTH2R) is concentrated in endocrine and limbic regions in the forebrain. Its endogenous ligand, tuberoinfundibular peptide of 39 residues (TIP39), is synthesized in only two brain regions, within the posterior thalamus and the lateral pons.
Dobolyi, Arpád +3 more
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The Calcium-sensing Receptor and Integrins in Cellular Differentiation and Migration
Frontiers in Physiology, 2016 The calcium-sensing receptor (CaSR) is a widely expressed homodimeric G-protein coupled receptor structurally related to the metabotropic glutamate receptors and GPRC6A.
David R Hampson +1 more
doaj +1 more source
JBMR Plus, 2022 Albright hereditary osteodystrophy (AHO) is caused by heterozygous inactivation of GNAS, a complex locus that encodes the alpha‐stimulatory subunit of heterotrimeric G proteins (Gsα) in addition to NESP55 and XLαs due to alternative first exons.
Patrick McMullan +4 more
doaj +1 more source
1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells. [PDF]
, 1984 The human-derived promyelocytic leukemia cell line, HL-60, is known to differentiate into mature myeloid cells in the presence of 1,25-dihydroxyvitamin D3 (1,25[OH]2D3).
Donaldson, CA +5 more
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Binding specificity of the ectodomain of the parathyroid hormone receptor [PDF]
Biophysical Chemistry, 2011 The parathyroid hormone (PTH)1 receptor is a member of the class B G protein-coupled receptor (GPCR) family and regulates bone and mineral metabolism of vertebrates. A truncated highly active parathyroid hormone fragment PTH (1-34) exerts stimulatory effects on the receptor and is used for treatment of osteoporosis. To study the interacting amino acids
Nils, Drechsler +6 more
openaire +2 more sources
Discontinuing Long‐Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?
Clinical Pharmacology &Therapeutics, EarlyView.Discontinuation of denosumab (Dmab) may be necessary due to adverse events or an unfavorable long‐term risk–benefit profile. However, accumulating evidence demonstrates pronounced rebound phenomena after withdrawal, most notably a marked increase in multiple vertebral fractures, and, in some reports, elevated mortality.
Ko‐Hsiu Lu +5 more
wiley +1 more source
Effects of Parathyroid Hormone on Immune Function
Clinical and Developmental Immunology, 2010 Parathyroid hormone (PTH) function as immunologic mediator has become interesting with the recent usage of PTH analogue (teriparatide) in the management of osteoporosis.
Abdallah Sassine Geara +7 more
doaj +1 more source
Evolution of Parathyroid Hormone Receptor Family and Their Ligands in Vertebrate [PDF]
, 2015 published_or_final_versio
Chow, BKC, Lee, LTO, ON, SW
core +1 more source