Results 71 to 80 of about 39,335 (289)

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Sclerostin antibodies as novel anabolic therapy for osteoporosis

Остеопороз и остеопатии, 2019
Osteoporosis medications are dividedinto two groups: those inhibiting bone resorption and formation (bisphosphonates and denosumab), and those stimulating bone formation i.e. having an anabolic effect. The latter include teriparatide, parathyroid hormone
Elizaveta O. Mamedova, Tatiana A. Grebennikova, Zhanna E. Belaya, Liudmila Y. Rozhinskaya   +3 more
doaj   +1 more source

Vitamin D. a dynamic molecule. how relevant might the dynamism for a vitamin be [PDF]

, 2015
Cholecalciferol, the precursor of Vitamin D3, is a very old, highly conserved, molecule. Its presence is evident in non-mineralized 750 million-year-old living species, such as plankton.
Mazzaferro, Sandro, Pasquali, Marzia
core   +2 more sources

Women with epilepsy: Evidence‐based counseling across the lifespan

Epilepsia, EarlyView.
Abstract Women with epilepsy (WWE) encounter distinct and evolving challenges across the lifespan that require clinical management extending beyond seizure control alone. Although awareness of sex‐specific aspects of epilepsy has increased, important gaps remain in their integration into routine care.
Barbara Tettenborn, Georgia Ramantani, Dominique Flügel, Verena Gaus, Susanne Schubert‐Bast, Elisabeth Sellitto, Jennifer Bausch, Bettina Schmitz   +7 more
wiley   +1 more source

Receptor oligomerization in family B1 of G-protein-coupled receptors: Focus on BRET investigations and the link between GPCR oligomerization and binding cooperativity

Frontiers in Endocrinology, 2012
The superfamily of the seven transmembrane G-protein-coupled receptors (7TM/GPCRs) is the largest family of membrane-associated receptors. GPCRs are involved in the pathophysiology of numerous human diseases, and they constitute an estimated 30-40 % of ...
Sarah Norklit Roed, Anne eOrgaard, Rasmus eJorgensen, Pierre eDe Meyts   +3 more
doaj   +1 more source

Vitamin D Pretreatment to Prevent the Risk of Postoperative Hypocalcemic Complications After Parathyroidectomy in Primary Hyperparathyroidism: A Systematic Review and Meta‐Analysis

Head &Neck, EarlyView.
ABSTRACT Background Parathyroidectomy is the treatment for primary hyperparathyroidism, yet postoperative hypocalcemia and hungry bone syndrome remain common. Vitamin D deficiency has been suggested as a modifiable risk factor, but evidence supporting preoperative supplementation is inconsistent.
Matthew Gynn, Helia Mansouri Dana, Oleksandr Butskiy   +2 more
wiley   +1 more source

Small Molecule Inhibited Parathyroid Hormone Mediated cAMP Response by N–Terminal Peptide Binding [PDF]

, 2016
Ligand binding to certain classes of G protein coupled receptors (GPCRs) stimulates the rapid synthesis of cAMP through G protein. Human parathyroid hormone (PTH), a member of class B GPCRs, binds to its receptor via its N–terminal domain, thereby ...
A Kumar, A Kumar, A Kumar, A Kumar, AA Pioszak, AG Gilman, C Santini, D Filmore, DE Ehrnhoefer, DF Mierke, DI Hammoudeh, DJ Adams, E Bosse-Doenecke, E Mossessova, F Hausch, G Gasser, GW Tregear, H Abu Ali, I Manet, IM McDonald, JA Salon, JC Ebert, JM Berg, JP Chinta, JP Overington, JP Vilardaga, KL Pierce, L Monticelli, L Pietrogrande, LG Raisz, LG Raisz, LM Young, M Castro, M Congreve, M De Amici, M Gopalswamy, M Rosenblatt, M Scian, MR Rao, N Drechsler, N Raman, PH Carter, R Mann, R Zhang, RB Miguel, RC Gensure, RS Yamgar, S Glatt, S Maretto, SK Lim, SN Georgiades, SR Nussbaum, TJ Gardella, TJ Gardella, TJ Kamerzell, TM Murray, UC Marx, UC Marx, UC Marx, VL Bodiga, XQ Zhou, ZS Agus   +61 more
core   +1 more source

Cancer Risk in Marfan Syndrome: A Swedish Population‐Based Cohort Study

International Journal of Cancer, EarlyView.
The cancer risk in Marfan syndrome, an autosomal dominant connective tissue disorder, largely remains to be explored. In this population‐based matched cohort study of 1544 Swedish patients, the overall cancer risk in adults with Marfan syndrome showed no significant increase, except for the risk of endocrine tumours with a nearly threefold increase ...
Ida Nordgren, Anna Skarin Nordenvall, Alexandra Wachtmeister, Fulya Taylan, Yunxia Lu, Christina Norrby, Anna Lindstrand, Giedre Grigelioniene, Giorgio Tettamanti   +8 more
wiley   +1 more source

Pharmacokinetics of evocalcet in secondary hyperparathyroidism patients receiving hemodialysis: first-in-patient clinical trial in Japan

Clinical Pharmacology: Advances and Applications, 2018
Takashi Shigematsu,1 Ryutaro Shimazaki,2 Masafumi Fukagawa,3 Tadao Akizawa4 On behalf of the Evocalcet Study Group 1Department of Nephrology, Wakayama Medical University, Wakayama, Japan; 2R&D Division, Kyowa Hakko Kirin Co., Ltd., Chiyoda-ku, Tokyo,
Shigematsu T, Shimazaki R, Fukagawa M, Akizawa T   +3 more
doaj  

Control of lipolysis in intra-abdominal fat cells of nonhuman primates: comparison with humans.

Journal of Lipid Research, 1995
The mechanisms that control lipolysis in intra-abdominal fat cells from various primate species, the marmoset (Callithrix jacchus), the baboon (Papio papio), and the macaque (Macaca fascicularis), were compared to those of human intraabdominal fat cells.
A Bousquet-Mélou, J Galitzky, M Lafontan, M Berlan   +3 more
doaj   +1 more source