Results 91 to 100 of about 21,293 (242)

Effect of Two Therapeutic Renal Diets on Hormonal and Regulatory Pathways Affecting Calcium Homeostasis in Cats With Early‐Stage Chronic Kidney Disease

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Chronic kidney disease (CKD) is a known risk factor for hypercalcemia in cats. Phosphate‐restricted diets have also been implicated in causing hypercalcemia, in part because phosphate restriction increases the Ca:P ratio. The primary objective of this study was to evaluate the impact of two different therapeutic renal foods on ionized (iCa ...
Jean A. Hall, Elizabeth M. Morris, Dale A. Fritsch, John J. Brejda, Kim M. Wilson   +4 more
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Core conformation of arrestin coupling to parathyroid hormone type 1 receptor

Nature Communications
The recruitment of β-arrestin (βarr) by G-protein-coupled receptor (GPCR) holds imperative importance in physiological processes, while the mechanisms underlying arrestin engagement with receptors remain obscure.
Xiuwen Zhai, Jia Guo, Qingya Shen, Li-Nan Chen, Gang Wang, Dan-Dan Shen, Changming Zhang, Xiaodong Xu, Chunyou Mao, Yan Zhang, Zhihong Liu   +10 more
doaj   +1 more source

Osteoporosis and Periodontitis: Two‐Way Epidemiological and Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review investigates the main mechanistic pathways connecting local periodontitis to systemic osteoporosis. Seven interconnected mechanisms are identified. ABSTRACT Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden.
Jia Chang, Geeta Madhuri Bhuvanagiri, Megan Dulkanchainun, Cunyu Wang   +3 more
wiley   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Combined Effects of Romosozumab and Zoledronate on the Development of Osteonecrosis of the Jaw

Oral Diseases, EarlyView.
ABSTRACT Objective This study aimed to assess the occurrence of medication‐related osteonecrosis of the jaw (MRONJ) in mice following the sequential administration of romosozumab and zoledronate and to confirm their inhibitory effects on osteoclast differentiation in vitro.
Hae‐Seo Park, Shihyun Kim, Seo‐Yeong An, Reuben H. Kim, Jongho Choi, Moon‐Young Kim   +5 more
wiley   +1 more source

Oral Delivery of Bioencapsulated CTB‐Pro‐IGF‐1 Enhances Bone Regeneration in a Pre‐Clinical Rat Model of Jaw Osteoradionecrosis

Oral Diseases, EarlyView.
ABSTRACT Objective Head and neck cancer radiotherapy can lead to jaw osteoradionecrosis (ORN). There is currently no definitive treatment for ORN. The efficacy of a novel orally delivered aglycosylated IGF‐1 with an E‐peptide (CTB‐Pro‐IGF‐1), bioencapsulated in plant cells, was evaluated as therapy for jaw ORN in rats. Materials and Methods Rat jaw ORN
Sunday O. Akintoye, Arularasan Anbinselvam, Prasath Jeyaraman, Uddhab Karki, Geetanjali Wakade, Henry Daniell   +5 more
wiley   +1 more source

Chinese Guideline on Risk Management of Osteoporosis in the General Public

Orthopaedic Surgery, EarlyView.
Summary of the background, key recommendations, and expected impact of the public guideline for osteoporosis risk management. ABSTRACT Background Osteoporosis is a common chronic skeletal disorder characterized by decreased bone mass and microarchitectural deterioration, resulting in increased fragility and fracture risk. With rapid population aging in
Shiyong Zhang, Jinqiu Yuan, Zhuojing Luo, Jiacan Su, Weibo Xia, Kehu Yang, Fuxin Wei, Osteoporosis Group, Chinese Association of Orthopaedic Surgeons, Youth Osteoporosis Group, Chinese Orthopaedic Association, Chinese Medical Association, Health Communication Branch, Chinese Preventive Medicine Association, Spine and Joint Health Branch, Guangdong Health Care Association, Chinese Health Risk Management Collaboration–Osteoporosis Group (CHRIMAC‐OP), Zhuojing Luo, Jiacan Su, Weibo Xia, Kehu Yang, Fuxin Wei, Jinqiu Yuan, Xiao Chen, Bo Gao, Yang Guo, Xiaofeng Gong, Junjie Huang, Yafang Huang, Tianyong Hou, Da He, Bin Liu, Yajun Liu, Fangping Li, Ying Li, Wei Li, Jiang Li, Zhihao Li, Xiahong Lin, Houqing Long, Jianwen Mo, Wenfei Ni, Yuanjun Teng, Liang Wang, Xiaobin Wang, Hongli Wang, Nan Wu, Hongfei Xiang, Bin Yan, Dejin Yang, Min Yang, Wei Ye, Hongping Yu, Ziji Zhang, Shiyong Zhang, Xinyu Chen, Ningning Chen, Qiangsheng He, Linmin Hu, Wenjing Li, Zijun Li, Qiji Li, Chengkai Lin, Qingfeng Luo, Tianyi Liu, Ningning Mi, Mina Ma, Jun Shen, Peng She, Huidong Tian, Siqing Wu, Junming Wan, Yongsheng Wang, Bin Xia, Peng Xie, Jinyu Zhao, Fei Zhang, Penghui Zhang, Danni Wang, Lei Cheng, Zhongshi Li, Xinyu Liu, Jing Wang, Shengping Yang, Binsheng Yu   +84 more
wiley   +1 more source

Factors Associated With Accelerated Fracture Healing in Patients With Traumatic Brain Injury and Extremity Comminuted Fractures: A Retrospective Case–Control Study

Orthopaedic Surgery, EarlyView.
In patients with traumatic brain injury and comminuted fractures, accelerated healing is independently predicted by younger age and greater TBI severity (lower GCS score). These factors may inform clinical decision‐making and provide insight into neurohumoral regulation of bone regeneration.
Xueqian Li, Rongrong Cao, Cheng Wang, Zhengsheng Chen, Jieyuan Zhang, Qing Li, Xin Ma   +6 more
wiley   +1 more source