Results 151 to 160 of about 2,320,796 (216)

Targeting nerve growth factor: an Achilles' heel for tumors? [PDF]

J Immunother Cancer
Repasky E, Mohammadpour H.
europepmc   +1 more source

Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder. [PDF]

Autism Res
Fernandez A, Sarn N, Eng C, Wright KM.
europepmc   +1 more source

Reinvigorating drug development around NGF signaling for pain. [PDF]

J Clin Invest
Wangzhou A, Price TJ.
europepmc   +1 more source

CRISPR-edited DPSCs constitutively expressing BDNF enhance dentin regeneration in injured teeth. [PDF]

Elife
Kim JH, Irfan M, Sreekumar S, Phimon A, Kim S, Chung S.   +5 more
europepmc   +1 more source

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Expression of neurotrophin receptor TrkA inhibits angiogenesis in neuroblastoma.

Medical and Pediatric Oncology, 2000
Mechanisms regulating the expression of angiogenic factors in tumor cells are largely unknown. High expression of the neurotrophin receptor TrkA in neuroblastomas (NB) is associated with favorable prognosis, whereas TrkB is expressed on aggressive, MYCN-amplified NB.To investigate the biological effects of TrkA and TrkB expression on angiogenesis in NB,
A. Eggert, A. Eggert, A. Eggert, M. Grotzer, M. Grotzer, N. Ikegaki, N. Ikegaki, Xing-ge Liu, Xing-ge Liu, A. Evans, A. Evans, G. Brodeur, G. Brodeur   +12 more
semanticscholar   +3 more sources

Proteasomal inhibition alters the trafficking of the neurotrophin receptor TrkA.

Biochemical and Biophysical Research Communications, 2009
Neurotrophin receptors of the Trk family promote neuronal survival. The signal transduction of Trk receptors is regulated by endosomal trafficking. Monoubiquitination of receptor tyrosine kinases is an established signal for sorting of internalized receptors to late endosomes.
T. Moises, S. Wüller, S. Saxena, J. Senderek, J. Weis, A. Krüttgen   +5 more
semanticscholar   +3 more sources

Constitutive TrkA Activity in Receptor-Overexpressing PC12 Clones

Biochemical and Biophysical Research Communications, 2002
We have studied ligand-independent signaling by the nerve growth factor receptor TrkA in PC12 clones, under conditions of receptor overexpression. Our results indicate that TrkA-overexpressing PC12 clones display constitutive receptor activation, involving both the mature, 140-kDa form and the immature, intracellular 110-kDa form of the receptor ...
Leoni C, VALTORTA , FLAVIA
openaire   +2 more sources

Tracking TrkA’s Trafficking: NGF Receptor Trafficking Controls NGF Receptor Signaling

Molecular Neurobiology, 2007
Growth factors such as the neurotrophins promote neuronal survival and shape neuronal morphology. Neurotrophin receptors are located on the surface of axons and dendrites and must convey their signal retrogradely to the nucleus to influence transcription of target genes. The distance between the site of receptor activation and the nucleus is tremendous.
T, Moises, A, Dreier, S, Flohr, M, Esser, E, Brauers, K, Reiss, D, Merken, J, Weis, A, Krüttgen   +8 more
openaire   +2 more sources