Results 171 to 180 of about 1,251,047 (226)

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis. [PDF]

Adv Sci (Weinh)
Wang Y, Xu L, Pan C, Cao R, Zeng P, Lyu X, Hu Q, Yan Z, Huang S, Dang N.   +9 more
europepmc   +1 more source

Transient Receptor Potential Melastatin 8 Plays a Key Role in Dextran Sulfate Sodium-Induced Murine Colitis via Regulating Extrinsic Sensory Neurons and Enteric Macrophage Secretory Activities. [PDF]

Neurogastroenterol Motil
Matsumoto K, Nakamoto T, Sato A, Utsumi D, Tachi M, Yamane S, Shibata S, Makino Y, Higashiura T, Kawaoka M, Sumi R, Suzuki A, Kato S.   +12 more
europepmc   +1 more source

Yifei Decoction Regulates the NGF/TRKA/PI3K/AKT Signaling Axis to Inhibit the Epithelial-Mesenchymal Transformation and Proliferation of Pulmonary Epithelial Cells in Bleomycin-Induced Pulmonary Fibrogenesis. [PDF]

Can Respir J
Chen L, Lan C, Deng X, Wu M, Shao M, Yang M, Ma X, Huang F, Wu H.   +8 more
europepmc   +1 more source

Neural regulation of bone: from central neural circuits to peripheral innervation of the skeletal stem cell niche. [PDF]

Bone Res
Chen Z, Luo Z, Greenblatt MB, Wu Z, Xu R.   +4 more
europepmc   +1 more source

TrkA Co-Receptors: The Janus Face of TrkA?

Cancers, 2023
Larotrectinib and Entrectinib are specific pan-Trk tyrosine kinase inhibitors (TKIs) approved by the Food and Drug Administration (FDA) in 2018 for cancers with an NTRK fusion. Despite initial enthusiasm for these compounds, the French agency (HAS) recently reported their lack of efficacy. In addition, primary and secondary resistance to these TKIs has
Robert-Alain Toillon, Chann Lagadec
exaly   +4 more sources

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Functional expression of TrkA receptors in hippocampal neurons

Journal of Neuroscience Research, 1998
Nerve growth factor (NGF) initiates its biological effects by promoting the dimerization and activation of the tyrosine kinase receptor TrkA. The requirements for NGF signaling through the TrkA receptor have been defined extensively from studies in immortalized cells, involving transfection of NIH 3T3, COS, and PC12 cells.
Aibel, Lani, Martín-Zanca, Dionisio, Pérez González, Pilar, Chao, Moses V.   +3 more
openaire   +3 more sources

The Neurotrophin Receptors TrkA and TrkB are Inhibitory for Neurite Outgrowth

European Journal of Neuroscience, 1995
AbstractTo investigate the possibility that the neurotrophin tyrosine kinase receptors are also recognition molecules by virtue of their immunoglobulin‐like domains, the ability of TrkA and TrkB to influence neurite outgrowth was tested in vitro. Cell monolayers of fibroblasts transfected to express either the TrkA or TrkB receptor reduced neurite ...
Tannahill, L., Klein, R., Schachner, M.
openaire   +3 more sources

Proteasomal inhibition alters the trafficking of the neurotrophin receptor TrkA

Biochemical and Biophysical Research Communications, 2009
Neurotrophin receptors of the Trk family promote neuronal survival. The signal transduction of Trk receptors is regulated by endosomal trafficking. Monoubiquitination of receptor tyrosine kinases is an established signal for sorting of internalized receptors to late endosomes.
T, Moises, S, Wüller, S, Saxena, J, Senderek, J, Weis, A, Krüttgen   +5 more
openaire   +2 more sources

Expression of neurotrophin receptor TrkA inhibits angiogenesis in neuroblastoma

Medical and Pediatric Oncology, 2000
Mechanisms regulating the expression of angiogenic factors in tumor cells are largely unknown. High expression of the neurotrophin receptor TrkA in neuroblastomas (NB) is associated with favorable prognosis, whereas TrkB is expressed on aggressive, MYCN-amplified NB.To investigate the biological effects of TrkA and TrkB expression on angiogenesis in NB,
A, Eggert, M A, Grotzer, N, Ikegaki, X G, Liu, A E, Evans, G M, Brodeur   +5 more
openaire   +2 more sources