Results 191 to 200 of about 27,380 (228)
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The Ran binding protein RanBPM interacts with TrkA receptor
Neuroscience Letters, 2006RanBPM as a novel binding protein can interact with neurotrophin receptor p75NTR and tyrosine kinase receptor Met which has a similar tyrosine kinase structure as receptor TrkA has. Whether RanBPM interacts with neurotrophin receptor TrkA has not been established to date. In this study, using yeast two-hybrid system, it was identified that RanBPM bound
Yuhe, Yuan +5 more
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TrkA NGF receptor expression by non-cholinergic thalamic neurons
NeuroReport, 1993Expression of the trkA receptor for nerve growth factor was analyzed by mRNA in situ hybridization in the telencephalon and diencephalon in adult rats. Two densely packed populations expressing trkA mRNA were detected in the thalamus, in the paraventricular thalamic nucleus anterior and reuniens thalamic nucleus.
J L, Venero, F, Hefti
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N-acetylglucosaminyltransferase V Modifies TrKA Protein, Regulates the Receptor Function
Cellular and Molecular Neurobiology, 20081. N-Acetylglucosaminyltransferases V (GnT-V/Mgat5) play a pivotal role in the processing of N-linked glycoproteins in the Golgi apparatus. The aim of the present study is to investigate whether the N-acetylglucosaminyltransferase V is able to modify TrKA, the high-affinity tyrosine kinase-type receptor for NGF, and thereby to regulate the receptor ...
Xiaoyun, Yang, Jing, Li, Meiyu, Geng
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Biological effects of TrkA and TrkB receptor signaling in neuroblastoma
Cancer Letters, 2005The Trk family consists of three receptor tyrosine kinases, each of which can be activated by one or more of four neurotrophins-NGF, BDNF, NT3 and NT4. Neurotrophins mediate their multiple effects through a number of distinct intracellular signaling cascades regulating such diverse biological responses as cell survival, proliferation and ...
Schramm, Alexander +9 more
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Proteasomal inhibition alters the trafficking of the neurotrophin receptor TrkA
Biochemical and Biophysical Research Communications, 2009Neurotrophin receptors of the Trk family promote neuronal survival. The signal transduction of Trk receptors is regulated by endosomal trafficking. Monoubiquitination of receptor tyrosine kinases is an established signal for sorting of internalized receptors to late endosomes.
T, Moises +5 more
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Proteins: Structure, Function, and Bioinformatics, 2004
AbstractMNAC13, a mouse monoclonal antibody, recognizes with high affinity and specificity the neurotrophin receptor TrkA and displays a neutralizing activity toward the NGF/TrkA interaction. Detailed knowledge of the molecular basis determining the specificity of this antibody is of importance because of its potential use as a modulator of the TrkA ...
Covaceuszach S, Cattaneo A, Lamba D
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AbstractMNAC13, a mouse monoclonal antibody, recognizes with high affinity and specificity the neurotrophin receptor TrkA and displays a neutralizing activity toward the NGF/TrkA interaction. Detailed knowledge of the molecular basis determining the specificity of this antibody is of importance because of its potential use as a modulator of the TrkA ...
Covaceuszach S, Cattaneo A, Lamba D
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The Neurotrophin Receptors TrkA and TrkB are Inhibitory for Neurite Outgrowth
European Journal of Neuroscience, 1995AbstractTo investigate the possibility that the neurotrophin tyrosine kinase receptors are also recognition molecules by virtue of their immunoglobulin‐like domains, the ability of TrkA and TrkB to influence neurite outgrowth was tested in vitro. Cell monolayers of fibroblasts transfected to express either the TrkA or TrkB receptor reduced neurite ...
Tannahill, L., Klein, R., Schachner, M.
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The International Journal of Biochemistry & Cell Biology, 2009
The ubiquitin-proteasome pathway regulates many biological processes, including protein degradation, receptor endocytosis, protein sorting, subnuclear trafficking and neuronal differentiation. While proteasome inhibition is known to induce neurite outgrowth, the signaling mechanisms that mediate these effects have not been defined.
Eun Joo, Song +2 more
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The ubiquitin-proteasome pathway regulates many biological processes, including protein degradation, receptor endocytosis, protein sorting, subnuclear trafficking and neuronal differentiation. While proteasome inhibition is known to induce neurite outgrowth, the signaling mechanisms that mediate these effects have not been defined.
Eun Joo, Song +2 more
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A Designed Peptidomimetic Agonistic Ligand of TrkA Nerve Growth Factor Receptors
Molecular Pharmacology, 2000A proteolytically stable small molecule beta-turn peptidomimetic, termed D3, was identified as an agonist of the TrkA neurotrophin receptor. D3 binds the Ig-like C2 region of the extracellular domain of TrkA, competes the binding of another TrkA agonist, affords selective trophic protection to TrkA-expressing cell lines and neuronal primary cultures ...
S, Maliartchouk +6 more
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TrkA neurogenic receptor regulates differentiation of neuroblastoma cells.
Oncogene, 1995We examined events associated with neuronal differentiation of neuroblastoma cell line SH-SY5Y. Treatment with nerve growth factor (NGF) and aphidicolin, an inhibitor of DNA polymerases alpha and delta, induces terminal differentiation of SH-SY5Y cells.
W, Poluha, D K, Poluha, A H, Ross
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