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The Ran binding protein RanBPM interacts with TrkA receptor
Neuroscience Letters, 2006RanBPM as a novel binding protein can interact with neurotrophin receptor p75NTR and tyrosine kinase receptor Met which has a similar tyrosine kinase structure as receptor TrkA has. Whether RanBPM interacts with neurotrophin receptor TrkA has not been established to date. In this study, using yeast two-hybrid system, it was identified that RanBPM bound
Yuhe, Yuan +5 more
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Biological effects of TrkA and TrkB receptor signaling in neuroblastoma
Cancer Letters, 2005The Trk family consists of three receptor tyrosine kinases, each of which can be activated by one or more of four neurotrophins-NGF, BDNF, NT3 and NT4. Neurotrophins mediate their multiple effects through a number of distinct intracellular signaling cascades regulating such diverse biological responses as cell survival, proliferation and ...
Schramm, Alexander +9 more
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Tracking TrkA’s Trafficking: NGF Receptor Trafficking Controls NGF Receptor Signaling
Molecular Neurobiology, 2007Growth factors such as the neurotrophins promote neuronal survival and shape neuronal morphology. Neurotrophin receptors are located on the surface of axons and dendrites and must convey their signal retrogradely to the nucleus to influence transcription of target genes. The distance between the site of receptor activation and the nucleus is tremendous.
T, Moises +8 more
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Proteins: Structure, Function, and Bioinformatics, 2004
AbstractMNAC13, a mouse monoclonal antibody, recognizes with high affinity and specificity the neurotrophin receptor TrkA and displays a neutralizing activity toward the NGF/TrkA interaction. Detailed knowledge of the molecular basis determining the specificity of this antibody is of importance because of its potential use as a modulator of the TrkA ...
Covaceuszach S, Cattaneo A, Lamba D
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AbstractMNAC13, a mouse monoclonal antibody, recognizes with high affinity and specificity the neurotrophin receptor TrkA and displays a neutralizing activity toward the NGF/TrkA interaction. Detailed knowledge of the molecular basis determining the specificity of this antibody is of importance because of its potential use as a modulator of the TrkA ...
Covaceuszach S, Cattaneo A, Lamba D
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TrkA NGF receptor plays a role in the modulation of p75NTR expression
Neuroscience Letters, 2005The cellular response to nerve growth factor (NGF) is mediated by two structurally unrelated receptors, TrkA and p75 neurotrophin receptor (p75NTR), which have been shown to interact resulting in reciprocal modulation of function. In this study, we have examined the modulation of p75NTR protein expression by specific TrkA autophosphorylation sites in ...
Sherri L, Rankin +2 more
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TrkA and TrkC neurotrophin receptor-like proteins in the lizard gut
Cell and Tissue Research, 2001The tyrosine kinase proteins (Trk), encoded by the trk family of proto-oncogenes, mediate, in mammals, the action of neurotrophins, a family of growth factors acting on the development and maintenance of the nervous system. Neurotrophins and their specific receptors, TrkA, TrkB and TrkC, seem to be phylogenetically well preserved but, in reptiles, data
LUCINI, CARLA +5 more
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Receptor transmodulation in the p75 neurotrophin receptor trkA receptor system
2000Barker, Philip A. (Supervisor)
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Induction of TrkA receptor by retinoic acid in leukaemia cell lines
NeuroReport, 1997To explore the potential involvement of neurotrophins in the actions of retinoic acid (RA) on leukaemia differentiation, we examined the ability of RA to regulate the expression of neurotrophins and Trk receptors in several leukaemia cell lines. Expression of TrkA was dramatically induced by RA at both the mRNA and protein level in leukaemia cell lines
Xie, Ping LIFS +4 more
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Tetraspanin1 promotes NGF signaling by controlling TrkA receptor proteostasis
Cellular and Molecular Life Sciences, 2019The molecular mechanisms that control the biosynthetic trafficking, surface delivery, and degradation of TrkA receptor are essential for proper nerve growth factor (NGF) function, and remain poorly understood. Here, we identify Tetraspanin1 (Tspan1) as a critical regulator of TrkA signaling and neuronal differentiation induced by NGF.
Facundo Ferrero Restelli +5 more
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A role for NGF and its receptors TrKA and p75NTR in the progression of COPD
Biological Chemistry, 2016Abstract Nerve growth factor and its receptors, TrkA and p75NTR, are involved in inflammation and airways diseases, but their role in chronic obstructive pulmonary disease is still unclear and not well investigated. our data indicate the stage dependent variation of nerve growth factor and its receptors in chronic obstructive pulmonary disease ...
STABILE, Anna Maria +6 more
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