Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
Nature Communications, 2017 BRCA2 is essential for the repair of DNA damage; therefore, defects in BRCA2 are associated with tumorigenesis but also with increased susceptibility to genotoxic stress.
Jinping Liu +6 more
doaj +1 more source
Bivariate Genomic Footprinting Detects Changes in Transcription Factor Activity
Cell Reports, 2017 In response to activating signals, transcription factors (TFs) bind DNA and regulate gene expression. TF binding can be measured by protection of the bound sequence from DNase digestion (i.e., footprint).
Songjoon Baek +2 more
doaj +1 more source
cMet and fas receptor interaction inhibits death-inducing signaling complex formation in endothelial cells [PDF]
, 2005 Fas receptor is constitutively expressed on endothelial cells; however, these cells are highly resistant to Fas-mediated apoptosis. In this study, we examined death-inducing signaling complex (DISC) formation in endothelial cells after Fas receptor ...
Brady, H.J.M., Smyth, L.A.
core +1 more source
Chimeric Receptors of the Human C3a Receptor and C5a Receptor (CD88) [PDF]
Journal of Biological Chemistry, 1999 Chimeras were generated between the human anaphylatoxin C3a and C5a receptors (C3aR and C5aR, respectively) to define the structural requirements for ligand binding and discrimination. Chimeric receptors were generated by systematically exchanging between the two receptors four receptor modules (the N terminus, transmembrane regions 1 to 4, the second ...
Jörg Köhl +7 more
openaire +3 more sources
Molecular Therapy: Oncolytics, 2020 One of the major hurdles for cancer immunotherapy is the host’s innate antiviral defense mechanisms. They include innate immune cells, such as natural killer (NK) cells and macrophages, which can be recruited within hours to the site of injection to ...
Xinping Fu +3 more
doaj +1 more source
Insights into divalent cation regulation and G13-coupling of orphan receptor GPR35
Cell Discovery, 2022 Endogenous ions play important roles in the function and pharmacology of G protein-coupled receptors (GPCRs) with limited atomic evidence. In addition, compared with G protein subtypes Gs, Gi/o, and Gq/11, insufficient structural evidence is accessible ...
Jia Duan +12 more
doaj +1 more source
Activation of 5-HT 2A Receptor Disrupts Rat Maternal Behavior [PDF]
, 2019 Serotonin 5-HT2A receptor is widely distributed in the central nervous system and plays an important role in sensorimotor function, emotion regulation, motivation, executive control, learning and memory. We investigated its role in rat maternal behavior,
Davis, Collin +3 more
core +1 more source
Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET [PDF]
, 2010 Flp-In T-REx 293 cells expressing a wild type human M muscarinic acetylcholine receptor construct constitutively and able to express a Receptor Activated Solely by Synthetic Ligand (RASSL) form of this receptor on demand maintained response to the ...
Alvarez-Curto, Elisa +3 more
core +2 more sources
G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence
Computational and Structural Biotechnology Journal, 2019 Aging is a complex biological process that is inevitable for nearly all organisms. Aging is the strongest risk factor for development of multiple neurodegenerative disorders, cancer and cardiovascular disorders.
Paula Santos-Otte +5 more
doaj +1 more source
Structural basis of FPR2 in recognition of Aβ42 and neuroprotection by humanin
Nature Communications, 2022 The formyl peptide receptor 2 (FPR2) is involved in the pathogenesis of Alzheimer’s disease. Structures of FPR2 bound to Aβ42, humanin, or formyl peptides offer insight into Aβ42 neurotoxicity, humanin neuroprotection, and FPR ligand ...
Ya Zhu +10 more
doaj +1 more source