Results 111 to 120 of about 63,264 (143)

Expression and Distribution of Receptor Activator of Nuclear Factor Kappa B, Receptor Activator of Nuclear Factor Kappa B Ligand, and Osteoprotegerin in Periradicular Cysts

Journal of Endodontics, 2015
The receptor activator of nuclear factor kappa B (RANK)-RANK ligand (RANKL)-osteoprotegerin (OPG) system is important in osteoclastogenesis and may play a role in the development of apical periodontitis. This immunohistochemical study evaluated the distribution of the expression of these regulators of bone resorption in periradicular cysts.Biopsy ...
Luciana Dias, Siqueira J F, Fabio Pires   +2 more
exaly   +3 more sources

Influence of receptor activator of nuclear factor kappa B on human aortic valve myofibroblasts

Experimental and Molecular Pathology, 2005
Calcific aortic valve stenosis, the main heart valve disease in the elderly, is based on progressive calcification and fibrous thickening of the valve. Several reports addressed the pathogenesis of tissue calcification in this disorder, but few data exist on the molecular mechanisms of the fibrosis and remodeling of the extracellular matrix.
Jens J Kaden, Siegfried Hagl
exaly   +3 more sources

Influence of Calcium Hydroxide–loaded Microcapsules on Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa B Ligand Activity

Journal of Endodontics, 2014
Calcium hydroxide (Ca[OH]2) microcapsules were synthesized to allow controlled release of Ca(OH)2. The aim of this study was to evaluate the influence of Ca(OH)2 microcapsules on osteoprotegerin (OPG) activity, receptor activator of nuclear factor kappa B ligand (RANKL) activity, and the OPG/RANKL ratio compared with pure Ca(OH)2 powder and Vitapex ...
Xiaozhong Qu, Zhenzhong Yang, Bing Han   +2 more
exaly   +3 more sources

Cementocytes Express Receptor Activator of the Nuclear Factor Kappa-B Ligand in Response to Endodontic Infection in Mice

Journal of Endodontics, 2016
Although studies have recently shown that osteocytes embedded in mineralized bone matrix play an important role in bone diseases, the participation of cementocytes in apical periodontitis has not been evaluated. The aim of the present study was to evaluate the possible involvement of cementocytes in the development of apical periodontitis.Apical ...
Lea Silva, Paulo Nelson-Filho, Raquel Bezerra da Silva   +2 more
exaly   +3 more sources

Expression of receptor activator of nuclear factor kappa-B as a poor prognostic marker in breast cancer

Journal of Surgical Oncology, 2014
Hyung Seok Park
exaly   +2 more sources

Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts

Biochemical and Biophysical Research Communications, 2003
Receptor activator of nuclear factor kappa B (RANK) is a tumor necrosis factor receptor (TNFR) family protein that plays an important role in the regulation of bone and immune systems. Cellular responses to RANK ligand (RANKL) and the signal transduction pathways of RANK have been well characterized in osteoclasts and osteoclast precursor cells.
Zang Hee, Lee, Hong Hee, Kim
openaire   +2 more sources

Receptor Activator of Nuclear Factor kappa-B Ligand is Not Regulated During Chronic Osteomyelitis in Pigs

Journal of Comparative Pathology, 2020
Bone loss is a major complication of osteomyelitis and from numerous in-vitro studies, it has been concluded that the bone lysis is caused by elevated expression of the receptor activator of nuclear factor κB ligand (RANKL), leading to increased osteoclast activity.
Lüthje, F. L., Skovgaard, K., Jensen, H. E., Blirup-Plum, S. A., Henriksen, N. L., Aalbæk, B., Jensen, L. K.   +6 more
openaire   +3 more sources

Serum level of receptor activator of nuclear factor kappa‐B ligand in patients with psoriasis

International Journal of Dermatology, 2015
AbstractBackgroundPsoriasis usually precedes the onset of psoriatic arthritis by an average of 10 years in about 70% of patients. Receptor activator of nuclear factor kappa‐B ligand (RANKL) is a natural and necessary surface‐bound molecule, which is a ligand for osteoprotegrin and functions as a key factor for osteoclast differentiation and activation ...
Tarek E, Amin, Nashwa N, ElFar, Nahla R, Ghaly, Mona M, Hekal, Azza M, Hassan, Hanan M, Elsaadany   +5 more
openaire   +2 more sources

Regulation of Osteoblast Migration Involving Receptor Activator of Nuclear Factor‐kappa B (RANK) Signaling

Journal of Cellular Physiology, 2015
Bone remodeling requires osteoclast activation, resorption, and reversal, prior to osteoblast migration into the bone pit. The Receptor Activator of NF‐κB (RANK) signaling pathway plays an important role in bone remodeling. Two components of the RANK signaling pathway, RANK Ligand (RANKL) and the decoy receptor Osteoprotegerin (OPG), are expressed ...
Diana, Golden, Elizabeth A, Saria, Marc F, Hansen   +2 more
openaire   +2 more sources

Differential activation of the nuclear factor-kappa B by TNF muteins specific for the p60 and p80 TNF receptors

The Journal of Immunology, 1996
Abstract Human TNF is a highly pleiotropic cytokine that mediates its effects by binding to two distinct receptors, viz p60 and p80, which transmit their signals independently of each other. Activation of the transcription factor NF-kappa B is one of the earliest events induced by TNF, but whether it is mediated through one or both ...
G B, Chainy, S, Singh, U, Raju, B B, Aggarwal   +3 more
openaire   +2 more sources