Results 111 to 120 of about 169,031,329 (267)

Receptor activator of nuclear factor kappa B ligand(RANKL) modulates the expression of genes involved in apoptosis and cell cycle in human osteoclasts.

, 2007
It has been clearly established that receptor activator of nuclear factor kappa B ligand (RANKL) is a key cytokine involved in the differentiation of osteoclastic precursors of momocytic/macrophagic lineage.
FADDA R, ZWEYER, MARINA, RICCI E, RIMONDI, Erika, SECCHIERO P.   +4 more
core   +1 more source

Microenvironmental Drivers of Bone Disease in Multiple Myeloma: Oxidative Stress, Sterile Inflammation, Autophagy–Lysosomal Remodeling, and the Iron–Lipid Peroxidation Axis

Biomolecules
Multiple myeloma profoundly remodels the bone marrow microenvironment, causing osteolytic bone disease through a persistent uncoupling of bone resorption and formation. Beyond the canonical roles of the receptor activator of nuclear factor kappa-B ligand/
Maria Elisa Nasso, Adele Bottaro, Manlio Fazio, Fabio Stagno, Sebastiano Gangemi, Alessandro Allegra   +5 more
doaj   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Humoral Regulation of Osteoclasts and Their Role in Bone Resorption

Endocrinology Research and Practice, 2008
Osteoclasts are derived from the macrophage haematopoietic lineage, resemble monocyte-like phagocytic cells, and are involved in bone resorption. The cells of the bone and the immune system communicate by cytokines and growth factors.
Hatice Sebila Dökmetaş
doaj   +2 more sources

The change of receptor activator of nuclear factor kappa B ligand and osteoprotegerin in the patients with diabetic nephropathy (phase III,IV,V)

, 2010
Tıpta Uzmanlık TeziSon yıllarda kemik dokusu ile ilgili yapılan çalışmalarda osteosteoblastlar tarafından sekrete edilen osteoprotegerinin, reseptör aktivatör nükleer kappa B liganda bağlanarak osteoklastogenezi baskıladığı saptanmıştır.
Kuzugüden Sarı, Çiğdem
core   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Identification and functional characterization of the novel MAR-binding protein, SATB2 [PDF]

, 2004
The regulation of gene expression is governed in large part by transcription factors that bind to enhancers and promoters. The functions of transcription factors involve both the modulation of chromatin accessibility via the recruitment of histone ...
Dobreva, Gergana
core   +1 more source

Monosodium L-glutamate affects orthodontic outcomes by inhibiting hypothalamic-pituitary-gonadal axis function

Pakistan Journal of Pharmaceutical Sciences
Background: Orthodontic treatment involves complex bone remodeling, with the Osteoprotegerin (OPG)/Receptor Activator of nuclear factor Kappa-B Ligand (RANKL)/Receptor activator of nuclear factor Kappa-B (RANK) (OPG/RANKL/RANK) signaling pathway ...
Xiaofang Cai, Min Cai, Yuxiao Zhao, Jun Xiang, Feng Yang, Wen Zhu, Wei Bi, Xiaojun Ding   +7 more
doaj   +1 more source

In Rats, Whole and Refined Grains Decrease Bone Mineral Density and Content through Modulating Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa B. [PDF]

Biomedicines, 2023
Sakr H, Khired Z, Moghadas M.
europepmc   +1 more source