European review for medical and pharmacological sciences, 2010 AIMS/HYPOTHESIS: Our aims were to compare osteoclastic activity between patients with acute Charcot's osteoarthropathy and diabetic and healthy controls, and to determine the effect of the receptor activator of nuclear factor-kappaB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG).
Pandolfi, Franco +4 more
openaire +2 more sources
Advanced Science, EarlyView.Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin +10 more
wiley +1 more source
Estrogen receptor co-regulators as prognostic and predictive markers of endocrine therapy in early breast cancer: the role of SMRT and p160 family [PDF]
, 2010 Background: The estrogen receptor (ER) signaling pathway is the dominant driver of cell proliferation and survival in the majority of human breast cancers.
Migliaccio, Ilenia
core +1 more source
A review of denosumab for the treatment of osteoporosis
Patient Preference and Adherence, 2014 Tsuyoshi Miyazaki,1,2 Fumiaki Tokimura,1 Sakae Tanaka3 1Department of Orthopedic Surgery, 2Department of Geriatric Medicine, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Tokyo, Japan; 3Department of Orthopedic Surgery,
Miyazaki T, Tokimura F, Tanaka S
doaj
Direct and indirect regulation of bone metabolism by lactoferrin
Frontiers in EndocrinologyLactoferrin exerts positive regulation on bone metabolism through both direct and indirect pathways. Directly, it modulates osteoblasts, osteoclasts, and chondrocytes via factors such as insulin-like growth factor (IGF), low-density lipoprotein receptor ...
Yangyang Wu, Cunxin Zhang, Chaoliang Lv
doaj +1 more source
Lophatherum gracile Bronghiart Suppresses Receptor Activator of Nuclear Factor Kappa-B Ligand-Stimulated Osteoclastogenesis and Prevents Ovariectomy-Induced Osteoporosis. [PDF]
Int J Mol Sci, 2022 Lee SJ, Jang SA, Kim SC, Ryuk JA, Ha H.
europepmc +1 more source
Advanced Science, EarlyView.A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou +18 more
wiley +1 more source
Expressions of Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa-B Ligand in Alveolar Bone Socket under Low Plasma Estrogen Level Condition [PDF]
Journal of Krishna Institute of Medical Sciences University, 2017 Background: Decreasing of estrogen level can lead to alveolar bone loss. This bone loss reflects an imbalance between resorption and apposition. Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) is a key mediator in osteoclast activation ...
Agung Krismariono +3 more
doaj
Effects of Lactobacillus reuteri MG5346 on Receptor Activator of Nuclear Factor-Kappa B Ligand (RANKL)-Induced Osteoclastogenesis and Ligature-Induced Experimental Periodontitis Rats. [PDF]
Food Sci Anim Resour, 2023 Jeong YJ +4 more
europepmc +1 more source
Advanced Science, EarlyView.Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu +7 more
wiley +1 more source