Results 131 to 140 of about 112,514 (282)
Humoral Regulation of Osteoclasts and Their Role in Bone Resorption
Endocrinology Research and Practice, 2008 Osteoclasts are derived from the macrophage haematopoietic lineage, resemble monocyte-like phagocytic cells, and are involved in bone resorption. The cells of the bone and the immune system communicate by cytokines and growth factors.
Hatice Sebila Dökmetaş
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Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone
Advanced Science, EarlyView.In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman +15 more
wiley +1 more source
Advanced Science, EarlyView.Inspired by natural amino acid polymer‐melanin systems, this study strategically incorporated tellurocysteine to develop advanced radiation‐shielding materials. This approach transformed the primary interaction mechanism between melanin‐based materials and incident photons from Compton scattering to the photoelectric effect. Tellurocysteine‐polymerized
Wei Chen +6 more
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Direct and indirect regulation of bone metabolism by lactoferrin
Frontiers in EndocrinologyLactoferrin exerts positive regulation on bone metabolism through both direct and indirect pathways. Directly, it modulates osteoblasts, osteoclasts, and chondrocytes via factors such as insulin-like growth factor (IGF), low-density lipoprotein receptor ...
Yangyang Wu, Cunxin Zhang, Chaoliang Lv
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In Rats, Whole and Refined Grains Decrease Bone Mineral Density and Content through Modulating Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa B. [PDF]
Biomedicines, 2023 Sakr H, Khired Z, Moghadas M.
europepmc +1 more source
Advanced Science, EarlyView.Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu +15 more
wiley +1 more source
Expressions of Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa-B Ligand in Alveolar Bone Socket under Low Plasma Estrogen Level Condition [PDF]
Journal of Krishna Institute of Medical Sciences University, 2017 Background: Decreasing of estrogen level can lead to alveolar bone loss. This bone loss reflects an imbalance between resorption and apposition. Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) is a key mediator in osteoclast activation ...
Agung Krismariono +3 more
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Lophatherum gracile Bronghiart Suppresses Receptor Activator of Nuclear Factor Kappa-B Ligand-Stimulated Osteoclastogenesis and Prevents Ovariectomy-Induced Osteoporosis. [PDF]
Int J Mol Sci, 2022 Lee SJ, Jang SA, Kim SC, Ryuk JA, Ha H.
europepmc +1 more source
Advanced Science, EarlyView.This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo +11 more
wiley +1 more source
A review of denosumab for the treatment of osteoporosis
Patient Preference and Adherence, 2014 Tsuyoshi Miyazaki,1,2 Fumiaki Tokimura,1 Sakae Tanaka3 1Department of Orthopedic Surgery, 2Department of Geriatric Medicine, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Tokyo, Japan; 3Department of Orthopedic Surgery,
Miyazaki T, Tokimura F, Tanaka S
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