Results 131 to 140 of about 169,031,329 (267)

Decoding Chronic Charcot Arthropathy: Molecular Mechanisms, Predictive Biomarkers, and Emerging Therapies

JBJS Open Access
. » Chronic Charcot arthropathy results from the convergence of genetic predisposition (OPG/RANKL/RANK polymorphisms), metabolic disturbances (AGEs, vitamin D deficiency affecting 84.2% of patients), and inflammatory dysregulation (RANKL/OPG axis, IL-17 ...
Osama Embaby, MSc, Afdhal Bin Asmadi, MBBS, Aiman Binte Asmadi, MBBS, Mohamed Elalfy, MD   +3 more
doaj   +1 more source

Early identification of a 12-bp tandem duplication in TNFRSF11A encoding receptor activator of nuclear factor-kappa B (RANK): Clinical characterization and response to bisphosphonate therapy. [PDF]

Bone, 2023
Craven M, Vajravelu ME, Shekdar KV, Levine MA, Mumm S, Whyte MP, Mancilla EE.   +6 more
europepmc   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Osteoprotegerin and Soluble Receptor Activator of Nuclear Factor-Kappa B Ligand in Exudative Age-Related Macular Degeneration

Acta Medica Iranica, 2014
Calcification and inflammation are among the important cases of exudative age-related macular degeneration (E-ARMD). The aim of the present study was to elucidate if there is any relationship between serum Osteoprotegerin (OPG), soluble receptor ...
Amir Ghorbanihaghjo, Alireza Javadzadeh, Nadereh Rashtchizadeh, Rana Sorkhabi, Hasan Khalili, Babak Rahimi-Ardabili   +5 more
doaj  

Histological Grade and Tumor Stage Are Correlated with Expression of Receptor Activator of Nuclear Factor Kappa b (Rank) in Epithelial Ovarian Cancers. [PDF]

Int J Mol Sci, 2022
Gomez R, Tejada MÁ, Rodríguez-García V, Burgués O, Santos-Llamas AI, Martínez-Massa A, Marín-Montes A, Tarín JJ, Cano A.   +8 more
europepmc   +1 more source

Dicationic Ion‐Pair Doping Enables Stable and High‐Performing Conducting Polymers for Organic Thermoelectrics

Advanced Science, EarlyView.
TAB–2TFSI enables efficient ion‐pair doping across a wide range of conjugated polymers, where the strongly oxidizing TAB core drives charge transfer, and the TFSI counterions promote favorable ionic compensation. This dicationic dopant promotes uniform dopant distribution, improves structural order, and increases carrier delocalization, establishing a ...
Juhyung Park, Shubhradip Guchait, Tanmay Sinha, Cynthia Verduyckt, Vijitha Ignatious, Tzu‐Yi Yu, Heyi Xia, Altynay Kaidarova, Michael Ng, Siebe Detavernier, Martin Rosenthal, Maristella Alessio, Daniel Escudero, Guy Koeckelberghs, Francisco Molina‐Lopez   +14 more
wiley   +1 more source

Expression and Functional Evaluation of Recombinant Anti-receptor Activator of Nuclear Factor Kappa-B Ligand Monoclonal Antibody Produced in Nicotiana benthamiana. [PDF]

Front Plant Sci, 2021
Boonyayothin W, Sinnung S, Shanmugaraj B, Abe Y, Strasser R, Pavasant P, Phoolcharoen W.   +6 more
europepmc   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

Adenoviral transfer of murine oncostatin M elicits periosteal bone apposition in knee joints of mice, despite synovial inflammation and up-regulated expression of interleukin-6 and receptor activator of nuclear factor-kappa B ligand.

, 2002
Contains fulltext : 142117.pdf (Publisher’s version ) (Open Access)Oncostatin M (OSM) has been described as a bone-remodeling factor either stimulating osteoblast activity or osteoclast formation in vitro.
Diana S. de Jong, Jong, D.S. de, Fons A.J. van de Loo, Berg, W.B. van den, Alfons S.K. de Hooge, Richards, C.D., Onno J. Arntz, Arntz, O.J., Miranda B. Bennink, Hooge, A.S.K. de, Loo, F.A.J. van de, Wim B. van den Berg, Erik Lubberts, Bennink, M.B., Lubberts, G.J.H., Carl D. Richards   +15 more
core   +1 more source