Results 261 to 270 of about 112,514 (282)
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Receptor activator of nuclear factor kappa B ligand in an experimental intervertebral disc degeneration.

Clinical and experimental rheumatology, 2009
This study was designed to clarify the role of the receptor activator of nuclear factor kappa B ligand (RANKL) in the process of discus degeneration and spondylarthrosis. It was hypothesized that experimental discus lesion would initiate not only local bone remodelling but also increased osteoclast formation on a location remote to the injury site due ...
Z, Mackiewicz   +6 more
openaire   +1 more source

Receptor Activator of Nuclear Factor Kappa-B-Expressing Mesenchymal Stem Cells-Derived Extracellular Vesicles for Osteoporosis Therapy

ACS Nano
The dynamic balance between bone resorption and formation is critical for maintaining healthy bone homeostasis. However, the receptor activator of the nuclear factor B ligand (RANKL) primarily stimulates mature osteoclasts to resorb bone, and its upregulation leads to osteoporosis in patients.
Wenju Chang   +13 more
openaire   +2 more sources

Peptides targeting Receptor activator of nuclear factor-kappa B (RANK) and their applications

2013
The present invention relates to a polypeptide for use as a medicament in the treatment and/or prevention of a disease wherein the RANKL-RANK signaling pathway is involved, in particular a bone resorptive disease.
UNIV NANTES, CHU NANTES
openaire   +1 more source

Receptor activator of nuclear factor kappa B ligand-mediated osteoclastogenesis is elevated in ankylosing spondylitis.

Clinical and experimental rheumatology, 2009
Ankylosing spondylitis (AS) is an inflammatory arthritis involving the axial skeleton. Decreased bone mineral density has also been reported in AS patients. This study sought to determine whether osteoclastogenesis and osteoclast activity are increased in AS.Twenty patients with AS were evaluated using the Bath Ankylosing Spondylitis Disease Activity ...
C H, Im   +10 more
openaire   +1 more source

Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

Ca-A Cancer Journal for Clinicians, 2017
Cynthia Morata-Tarifa   +2 more
exaly  

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