Results 241 to 250 of about 169,031,329 (267)
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Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts
Biochemical and Biophysical Research Communications, 2003Receptor activator of nuclear factor kappa B (RANK) is a tumor necrosis factor receptor (TNFR) family protein that plays an important role in the regulation of bone and immune systems. Cellular responses to RANK ligand (RANKL) and the signal transduction pathways of RANK have been well characterized in osteoclasts and osteoclast precursor cells.
Zang Hee, Lee, Hong Hee, Kim
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Serum level of receptor activator of nuclear factor kappa‐B ligand in patients with psoriasis
International Journal of Dermatology, 2015AbstractBackgroundPsoriasis usually precedes the onset of psoriatic arthritis by an average of 10 years in about 70% of patients. Receptor activator of nuclear factor kappa‐B ligand (RANKL) is a natural and necessary surface‐bound molecule, which is a ligand for osteoprotegrin and functions as a key factor for osteoclast differentiation and activation ...
Tarek E, Amin +5 more
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Journal of Cellular Physiology, 2015
Bone remodeling requires osteoclast activation, resorption, and reversal, prior to osteoblast migration into the bone pit. The Receptor Activator of NF‐κB (RANK) signaling pathway plays an important role in bone remodeling. Two components of the RANK signaling pathway, RANK Ligand (RANKL) and the decoy receptor Osteoprotegerin (OPG), are expressed ...
Diana, Golden +2 more
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Bone remodeling requires osteoclast activation, resorption, and reversal, prior to osteoblast migration into the bone pit. The Receptor Activator of NF‐κB (RANK) signaling pathway plays an important role in bone remodeling. Two components of the RANK signaling pathway, RANK Ligand (RANKL) and the decoy receptor Osteoprotegerin (OPG), are expressed ...
Diana, Golden +2 more
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The Journal of Immunology, 1996
Abstract Human TNF is a highly pleiotropic cytokine that mediates its effects by binding to two distinct receptors, viz p60 and p80, which transmit their signals independently of each other. Activation of the transcription factor NF-kappa B is one of the earliest events induced by TNF, but whether it is mediated through one or both ...
G B, Chainy +3 more
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Abstract Human TNF is a highly pleiotropic cytokine that mediates its effects by binding to two distinct receptors, viz p60 and p80, which transmit their signals independently of each other. Activation of the transcription factor NF-kappa B is one of the earliest events induced by TNF, but whether it is mediated through one or both ...
G B, Chainy +3 more
openaire +2 more sources
Clinical and experimental rheumatology, 2009
This study was designed to clarify the role of the receptor activator of nuclear factor kappa B ligand (RANKL) in the process of discus degeneration and spondylarthrosis. It was hypothesized that experimental discus lesion would initiate not only local bone remodelling but also increased osteoclast formation on a location remote to the injury site due ...
Z, Mackiewicz +6 more
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This study was designed to clarify the role of the receptor activator of nuclear factor kappa B ligand (RANKL) in the process of discus degeneration and spondylarthrosis. It was hypothesized that experimental discus lesion would initiate not only local bone remodelling but also increased osteoclast formation on a location remote to the injury site due ...
Z, Mackiewicz +6 more
openaire +1 more source
Angiology
Cardiovascular and bone diseases contribute independently to mortality and global health. The exact mechanisms involved in the pathophysiology shared between bone and vascular diseases are not well defined. Endothelial cells and osteoblasts communicate during osteogenesis, thus establishing a connection between angiogenesis and osteogenesis. One shared
Gizem Celebi Torabfam +1 more
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Cardiovascular and bone diseases contribute independently to mortality and global health. The exact mechanisms involved in the pathophysiology shared between bone and vascular diseases are not well defined. Endothelial cells and osteoblasts communicate during osteogenesis, thus establishing a connection between angiogenesis and osteogenesis. One shared
Gizem Celebi Torabfam +1 more
openaire +3 more sources
Journal of surgical oncology, 2015
Receptor activator of nuclear factor kappa-B and its ligand (RANK/RANKL) and Osteoprotegerin (OPG) are key molecules for regulating osteoclastic activity in bone. However, little is known about the role of RANK-related molecules in breast cancer prognosis. We aimed to evaluate RANK, RANKL, and OPG expression and the associated clinical impact in breast
Hyung Seok, Park +5 more
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Receptor activator of nuclear factor kappa-B and its ligand (RANK/RANKL) and Osteoprotegerin (OPG) are key molecules for regulating osteoclastic activity in bone. However, little is known about the role of RANK-related molecules in breast cancer prognosis. We aimed to evaluate RANK, RANKL, and OPG expression and the associated clinical impact in breast
Hyung Seok, Park +5 more
openaire +1 more source
Clinical and experimental rheumatology, 2009
Ankylosing spondylitis (AS) is an inflammatory arthritis involving the axial skeleton. Decreased bone mineral density has also been reported in AS patients. This study sought to determine whether osteoclastogenesis and osteoclast activity are increased in AS.Twenty patients with AS were evaluated using the Bath Ankylosing Spondylitis Disease Activity ...
C H, Im +10 more
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Ankylosing spondylitis (AS) is an inflammatory arthritis involving the axial skeleton. Decreased bone mineral density has also been reported in AS patients. This study sought to determine whether osteoclastogenesis and osteoclast activity are increased in AS.Twenty patients with AS were evaluated using the Bath Ankylosing Spondylitis Disease Activity ...
C H, Im +10 more
openaire +1 more source