Results 231 to 240 of about 169,031,329 (267)

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Comparative evaluation of RANKL and OPG levels in gingival crevicular fluid and saliva during orthodontic treatment using thermoformed and direct-printed aligners. [PDF]

Dental Press J Orthod
Lakshmanan P, Baskaran S, Alamelu S, Baskar K.   +3 more
europepmc   +1 more source

Advanced glycation end products and RAGE signaling in diabetic cardiomyopathy: distinct mechanisms, human evidence, and translational barriers. [PDF]

Front Cardiovasc Med
Wang Z, Shi Q, Li X, Zhang Z, Li M.
europepmc   +1 more source

8-Epixanthatin Suppresses RANKL-Induced Osteoclast Differentiation via Inhibition of NF-κB and MAPK Signaling. [PDF]

Int J Mol Sci
Zhang L, Deepak V.
europepmc   +1 more source

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Expression and Distribution of Receptor Activator of Nuclear Factor Kappa B, Receptor Activator of Nuclear Factor Kappa B Ligand, and Osteoprotegerin in Periradicular Cysts

Journal of Endodontics, 2015
The receptor activator of nuclear factor kappa B (RANK)-RANK ligand (RANKL)-osteoprotegerin (OPG) system is important in osteoclastogenesis and may play a role in the development of apical periodontitis. This immunohistochemical study evaluated the distribution of the expression of these regulators of bone resorption in periradicular cysts.Biopsy ...
Luciana Dias, Siqueira J F, Fabio Pires   +2 more
exaly   +3 more sources

Receptor Activator of Nuclear Factor kappa-B Ligand is Not Regulated During Chronic Osteomyelitis in Pigs

Journal of Comparative Pathology, 2020
Bone loss is a major complication of osteomyelitis and from numerous in-vitro studies, it has been concluded that the bone lysis is caused by elevated expression of the receptor activator of nuclear factor κB ligand (RANKL), leading to increased osteoclast activity.
Lüthje, F. L., Skovgaard, K., Jensen, H. E., Blirup-Plum, S. A., Henriksen, N. L., Aalbæk, B., Jensen, L. K.   +6 more
openaire   +4 more sources

Influence of receptor activator of nuclear factor kappa B on human aortic valve myofibroblasts

Experimental and Molecular Pathology, 2005
Calcific aortic valve stenosis, the main heart valve disease in the elderly, is based on progressive calcification and fibrous thickening of the valve. Several reports addressed the pathogenesis of tissue calcification in this disorder, but few data exist on the molecular mechanisms of the fibrosis and remodeling of the extracellular matrix.
Jens J Kaden, Siegfried Hagl
exaly   +3 more sources

Influence of Calcium Hydroxide–loaded Microcapsules on Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa B Ligand Activity

Journal of Endodontics, 2014
Calcium hydroxide (Ca[OH]2) microcapsules were synthesized to allow controlled release of Ca(OH)2. The aim of this study was to evaluate the influence of Ca(OH)2 microcapsules on osteoprotegerin (OPG) activity, receptor activator of nuclear factor kappa B ligand (RANKL) activity, and the OPG/RANKL ratio compared with pure Ca(OH)2 powder and Vitapex ...
Xiaozhong Qu, Zhenzhong Yang, Bing Han   +2 more
exaly   +3 more sources

Cementocytes Express Receptor Activator of the Nuclear Factor Kappa-B Ligand in Response to Endodontic Infection in Mice

Journal of Endodontics, 2016
Although studies have recently shown that osteocytes embedded in mineralized bone matrix play an important role in bone diseases, the participation of cementocytes in apical periodontitis has not been evaluated. The aim of the present study was to evaluate the possible involvement of cementocytes in the development of apical periodontitis.Apical ...
Lea Silva, Paulo Nelson-Filho, Raquel Bezerra da Silva   +2 more
exaly   +3 more sources