Results 251 to 260 of about 112,514 (282)

Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts

Biochemical and Biophysical Research Communications, 2003
Receptor activator of nuclear factor kappa B (RANK) is a tumor necrosis factor receptor (TNFR) family protein that plays an important role in the regulation of bone and immune systems. Cellular responses to RANK ligand (RANKL) and the signal transduction pathways of RANK have been well characterized in osteoclasts and osteoclast precursor cells.
Zang Hee, Lee, Hong Hee, Kim
openaire   +4 more sources

Influence of receptor activator of nuclear factor kappa B on human aortic valve myofibroblasts

Experimental and Molecular Pathology, 2005
Calcific aortic valve stenosis, the main heart valve disease in the elderly, is based on progressive calcification and fibrous thickening of the valve. Several reports addressed the pathogenesis of tissue calcification in this disorder, but few data exist on the molecular mechanisms of the fibrosis and remodeling of the extracellular matrix.
Jens J, Kaden, Carl-Erik, Dempfle, Refika, Kiliç, Aslihan, Sarikoç, Siegfried, Hagl, Siegfried, Lang, Martina, Brueckmann, Martin, Borggrefe   +7 more
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Influence of Calcium Hydroxide–loaded Microcapsules on Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa B Ligand Activity

Journal of Endodontics, 2014
Calcium hydroxide (Ca[OH]2) microcapsules were synthesized to allow controlled release of Ca(OH)2. The aim of this study was to evaluate the influence of Ca(OH)2 microcapsules on osteoprotegerin (OPG) activity, receptor activator of nuclear factor kappa B ligand (RANKL) activity, and the OPG/RANKL ratio compared with pure Ca(OH)2 powder and Vitapex ...
Bing, Han, Xiaoyan, Wang, Jiguang, Liu, Fuxin, Liang, Xiaozhong, Qu, Zhenzhong, Yang, Xuejun, Gao   +6 more
openaire   +4 more sources

Human osteosarcoma cells express functional receptor activator of nuclear factor‐kappa B

The Journal of Pathology, 2007
AbstractRANK, RANK ligand (RANKL) and osteoprotegerin (OPG) are the key regulators of bone metabolism, both in normal and pathological conditions. Previous data have demonstrated that human osteosarcoma biopsies express RANKL as well as OPG, and functional RANK is expressed in a murine osteosarcoma cell line.
K, Mori, B, Le Goff, M, Berreur, A, Riet, A, Moreau, F, Blanchard, C, Chevalier, I, Guisle-Marsollier, J, Léger, J, Guicheux, M, Masson, F, Gouin, F, Rédini, D, Heymann   +13 more
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Regulation of Osteoblast Migration Involving Receptor Activator of Nuclear Factor‐kappa B (RANK) Signaling

Journal of Cellular Physiology, 2015
Bone remodeling requires osteoclast activation, resorption, and reversal, prior to osteoblast migration into the bone pit. The Receptor Activator of NF‐κB (RANK) signaling pathway plays an important role in bone remodeling. Two components of the RANK signaling pathway, RANK Ligand (RANKL) and the decoy receptor Osteoprotegerin (OPG), are expressed ...
Diana, Golden, Elizabeth A, Saria, Marc F, Hansen   +2 more
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Serum level of receptor activator of nuclear factor kappa‐B ligand in patients with psoriasis

International Journal of Dermatology, 2015
AbstractBackgroundPsoriasis usually precedes the onset of psoriatic arthritis by an average of 10 years in about 70% of patients. Receptor activator of nuclear factor kappa‐B ligand (RANKL) is a natural and necessary surface‐bound molecule, which is a ligand for osteoprotegrin and functions as a key factor for osteoclast differentiation and activation ...
Tarek E, Amin, Nashwa N, ElFar, Nahla R, Ghaly, Mona M, Hekal, Azza M, Hassan, Hanan M, Elsaadany   +5 more
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Receptor Activator of Nuclear Factor kappa-B Ligand is Not Regulated During Chronic Osteomyelitis in Pigs

Journal of Comparative Pathology, 2020
Bone loss is a major complication of osteomyelitis and from numerous in-vitro studies, it has been concluded that the bone lysis is caused by elevated expression of the receptor activator of nuclear factor κB ligand (RANKL), leading to increased osteoclast activity.
Lüthje, F. L., Skovgaard, K., Jensen, H. E., Blirup-Plum, S. A., Henriksen, N. L., Aalbæk, B., Jensen, L. K.   +6 more
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EP891 Receptor activator of nuclear factor kappa-B ligand expression predicts ovarian cancer outcome

ePoster, 2019
Introduction/Background The receptor activator of nuclear factor-κB (RANK) pathway, activated by RANK ligand (RANKL), critically controls bone metabolism and modulates tumour immune response. Denosumab, a neutralizing RANKL antibody, exerts tumour-suppressive effects in mice and humans. Herein, the relevance of RANK signalling was investigated for the
J Kögl, V Wieser, S Sprung, H Fiegl, C Marth, AG Zeimet   +5 more
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Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors

Journal of Surgical Oncology, 2002
AbstractBackground and ObjectivesOsteolytic bone tumors produce intercellular signaling proteins that regulate bone remodeling by altering the rates of osteoclast and osteoblast differentiation and activity. This report examines osteolytic bone tumor expression of receptor activator of nuclear factor B‐ligand (RANK‐L), a cytokine that is arguably the ...
Christopher R, Good, Regis J, O'Keefe, J Edward, Puzas, Edward M, Schwarz, Randy N, Rosier   +4 more
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Interleukin‐12 Induces Receptor Activator of Nuclear Factor‐Kappa B Ligand Expression by Human Periodontal Ligament Cells

Journal of Periodontology, 2017
Background: Increased level of proinflammatory cytokine interleukin (IL)‐12 correlates with the severity of periodontitis. Yet, a possible role of IL‐12 in periodontal disease has not been clarified. The aim of this study is to investigate whether IL‐12 affects expression of receptor activator of nuclear factor‐kappa B (NF‐κB) ligand (RANKL), a potent ...
Benjar, Issaranggun Na Ayuthaya, Vincent, Everts, Prasit, Pavasant   +2 more
openaire   +2 more sources