Results 281 to 290 of about 148,079 (360)

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Immunohistochemical detection of the receptor activator of nuclear factor Kappa B ligand and c-fos in giant cell granuloma.

J Oral Maxillofac Pathol, 2016
Ahmed AA, Dunlap C.
europepmc   +1 more source

Ethnic Variations in the Levels of Bone Biomarkers (Osteoprostegerin, Receptor Activator of Nuclear Factor Kappa-Β Ligand and Glycoprotein Non-Metastatic Melanoma Protein B) in People with Type 2 Diabetes [PDF]

Preethi Cherian, Irina Al‐Khairi, Mohamed Abu‐Farha, Tahani Alramah, Ahmed N. Albatineh, Doha Alhomaidah, Fayez F. Safadi, Hamad Ali, Muhammad Abdul‐Ghani, Jaakko Tuomilehto, Heikki A. Koistinen, Fahd Al‐Mulla, Jehad Abubaker   +12 more
openalex   +1 more source

Human coronary artery organ‐chip with circulating immune cells recapitulates anti‐inflammatory effect of pulsatile wall strain

Interdisciplinary Medicine, EarlyView.
A fully characterised organ‐on‐a‐chip model of the human coronary artery with endothelial and smooth muscle cells, plus circulating immune cells, created on the Emulate platform. The model successfully recapitulates the physiological effects of pulsatile vessel dilation on cell morphology and the localised inflammatory susceptibility to TNF‐α ...
Yu Hou, Georgios Ziakas, Tim Hopkins, Wen Wang, Hazel R. C. Screen, Martin M. Knight   +5 more
wiley   +1 more source

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

Occupational Exposure to Factory‐Derived Particulate Matter 2.5 Induces Cutaneous Toxicity in Workers and HaCaT Keratinocytes Through Oxidative Stress and Inflammation

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate the toxicological effects of occupational exposure to factory‐derived particulate matter (PM2.5) on human skin, emphasizing its role as a potential target organ of environmental toxicants. An epidemiological survey comparing factory and nonfactory workers was conducted by assessing their skin elasticity and color ...
Miku Tanaka, Masayuki Takaishi, Iroha Okuda, Toshiki Fujimoto, Mayumi Tsuji, Yuri Okano, Yasuhiro Ishihara, Maori Kono   +7 more
wiley   +1 more source

Tale of two transcription factors: NF-кB and HIF crosstalk [PDF]

, 2013
Bandarra, D., Rocha, S.
core   +1 more source

Immunomodulatory and Cytotoxic Properties of Enniatin B1 in Porcine Alveolar Macrophages

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study investigates the immunomodulatory effects of Enniatin B1 (ENNB1), an emerging mycotoxin, on porcine alveolar macrophages (PAMs), a species‐specific model relevant to human innate immunity. PAMs were exposed to increasing ENNB1 concentrations (0.5–6 μM) over 6, 24, and 48 h.
Sara Frazzini, Francesca Caloni, Paola Fossati, Giancarlo Ruffo, Luciana Rossi   +4 more
wiley   +1 more source

Decision Threshold Setting in Binary Classification Problems—A Behavioral Lens

Journal of Operations Management, EarlyView.
ABSTRACT When binary classification models are wrong, managers face misclassification costs. Although false positive outcomes imply unnecessary mitigation efforts, false negative outcomes imply overlooking the class of interest. Humans calibrate these ai models supporting operational systems by adjusting the decision threshold that translates ...
Patrick Moder, Kai Hoberg, Felix Papier
wiley   +1 more source

Alterations in brain metabolites in rats with experimental periodontitis: A metabolomic approach

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis (PD) is a chronic inflammatory disease with systemic effects. Emerging evidence suggests a link between periodontal inflammation and neurological changes, but the biochemical mechanisms in key brain regions, such as the hippocampus and amygdala, remain unclear.
Ramona Ramalho de Souza Pereira, Caíque Olegário Diniz e Magalhães, Elizabeth Luciana Marinho Miguel, Larissa Vieira Toledo, Débora Ribeiro Orlando, Alan Rodrigues Teixeira Machado, Bruno Del Bianco Borges, Luciano José Pereira, Marco Fabrício Dias‐Peixoto, Eric Francelino Andrade   +9 more
wiley   +1 more source