Results 71 to 80 of about 59,132 (205)

Advanced oxidation protein products induce inflammatory responses and invasive behaviour in fibroblast-like synoviocytes via the RAGE-NF-κB pathway

Bone & Joint Research, 2021
Aims: Rheumatoid arthritis (RA), which mainly results from fibroblast-like synoviocyte (FLS) dysfunction, is related to oxidative stress. Advanced oxidation protein products (AOPPs), which are proinflammatory mediators and a novel biomarker of oxidative
Aiju Lou, Le Wang, Weinan Lai, DingJi Zhu, Weirong Wu, Zhao Wang, Zihong Cai, Min Yang   +7 more
doaj   +1 more source

Methylglyoxal-dependent glycative stress and deregulation of SIRT1 functional network in the ovary of PCOS mice [PDF]

, 2020
Advanced glycation end-products (AGEs) are involved in the pathogenesis and consequences of polycystic ovary syndrome (PCOS), a complex metabolic disorder associated with female infertility.
Amicarelli, F, Cristiano, L, D'Alessandro, AM, Emidio, GD, Falone, S, Nottola, S, Palmerini, MG, Placidi, M, Rea, F, Rossi, G, Tatone, C   +10 more
core   +1 more source

The role of advanced glycation end-products in the development of coronary artery disease in patients with and without diabetes mellitus: a review

Molecular Medicine, 2018
Background Traditional risk factors are insufficient to explain all cases of coronary artery disease (CAD) in patients with diabetes mellitus (DM). Advanced glycation end-products (AGEs) and their receptors may play important roles in the development and
Sarah Louise Fishman, Halis Sonmez, Craig Basman, Varinder Singh, Leonid Poretsky   +4 more
doaj   +1 more source

Protein modification and maintenance systems as biomarkers of ageing [PDF]

, 2015
Changes in the abundance and post-translational modification of proteins and accumulation of some covalently modified proteins have been proposed to represent hallmarks of biological ageing.
Friguet, Bertrand, Gonos, Efstathios S, Libert, Claude, Petropoulos, Isabelle, Santos, Alexander Navarrete, Simm, Andreas, Vanhooren, Valerie, Voutetakis, Konstantinos   +7 more
core   +3 more sources

Assaying Soluble Forms of Receptor for Advanced Glycation End Products [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
In response: Yamagishi and Imaizumi speculate that kinetics and role of circulating total soluble form of receptor for advanced glycation endproducts (soluble receptor for AGE, sRAGE) may be different from those of endogenous secretory RAGE (esRAGE) in diabetes.
Yasuhiko Yamamoto, Junnosuke Miura, Shigeru Sakurai, Takuo Watanabe, Hideto Yonekura, Hironori Tamei, Hirokazu Matsuki, Ken-ichi Obata, Yasuko Uchigata, Yasuhiko Iwamoto, Hidenori Koyama, Hiroshi Yamamoto   +11 more
openaire   +1 more source

The AGE–RAGE–oxidative stress axis: A paradigm shift in understanding diabetic retinopathy

Indian Journal of Ophthalmology
Diabetic retinopathy (DR) represents a vision-threatening complication of diabetes, characterized by progressive damage to the retinal neurovascular network in both type 1 and type 2 diabetes.
Riya Srivastava, Deepak Mishra, Dipti Singh, M Yashwant Reddy, Samvidha Parihar, Kamlesh Palandurkar   +5 more
doaj   +1 more source

Postprandial Glucose Spikes, an Important Contributor to Cardiovascular Disease in Diabetes?

Frontiers in Cardiovascular Medicine, 2020
Clinical trials investigating whether glucose lowering treatment reduces the risk of CVD in diabetes have thus far yielded mixed results. However, this doesn't rule out the possibility of hyperglycemia playing a major causal role in promoting CVD or ...
Nordin M. J. Hanssen, Nordin M. J. Hanssen, Michael J. Kraakman, Michelle C. Flynn, Prabhakara R. Nagareddy, Casper G. Schalkwijk, Andrew J. Murphy, Andrew J. Murphy   +7 more
doaj   +1 more source

Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia [PDF]

, 2020
Background: Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer-associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy
Chiappalupi, S., Coletti, D., Donato, R., Renga, G., Riuzzi, F., Romani, L., Sagheddu, R., Salvadori, L., Sorci, G., Vukasinovic, A.   +9 more
core   +1 more source

Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD

Respiratory Research, 2021
Background Soluble receptor for advanced glycation end products (sRAGE) is a proposed emphysema and airflow obstruction biomarker; however, previous publications have shown inconsistent associations and only one study has investigate the association ...
Katherine A. Pratte, Jeffrey L. Curtis, Katerina Kechris, David Couper, Michael H. Cho, Edwin K. Silverman, Dawn L. DeMeo, Frank C. Sciurba, Yingze Zhang, Victor E. Ortega, Wanda K. O’Neal, Lucas A. Gillenwater, David A. Lynch, Eric A. Hoffman, John D. Newell, Alejandro P. Comellas, Peter J. Castaldi, Bruce E. Miller, Simon D. Pouwels, Nick H. T. ten Hacken, Rainer Bischoff, Frank Klont, Prescott G. Woodruff, Robert Paine, R. Graham Barr, John Hoidal, Claire M. Doerschuk, Jean-Paul Charbonnier, Ruby Sung, Nicholas Locantore, John G. Yonchuk, Sean Jacobson, Ruth Tal-singer, Debbie Merrill, Russell P. Bowler   +34 more
doaj   +1 more source

The galectin-3/RAGE dyad modulates vascular osteogenesis in atherosclerosis [PDF]

, 2013
Vascular calcification correlates with inflammation and plaque instability in a dual manner, depending on the spotty/granular (micro) or sheet-like/lamellated (macro) pattern of calcification.
BLASETTI FANTAUZZI, Claudia, Carlo M., Pesce, Familiari, Giuseppe, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe, Relucenti, Michela, Ricci, Carlo, Salvi, Laura, Taurino, Maurizio   +9 more
core   +1 more source