Results 51 to 60 of about 82,871,848 (297)

Transthyretin and Receptor for Advanced Glycation End Product’s Differential Levels Associated with the Pathogenesis of Rheumatoid Arthritis

Journal of Inflammation Research, 2021
Monu,1,2 Prachi Agnihotri,1 Mohd Saquib,1,2 Ashish Sarkar,1,2 Debolina Chakraborty,1,2 Uma Kumar,3 Sagarika Biswas1 1Council of Scientific and Industrial Research -Institute of Genomics & Integrative Biology (CSIR–IGIB), Delhi, 110007, India; 2Academy of
Monu, Agnihotri P, Saquib M, Sarkar A, Chakraborty D, Kumar U, Biswas S   +6 more
doaj  

Circulating Ligands of the Receptor for Advanced Glycation End Products and the Soluble Form of the Receptor Modulate Cardiovascular Cell Apoptosis in Diabetes

Molecules, 2020
We determined whether plasma concentrations of the receptor for advanced glycation end products (RAGE) and the soluble (s) form of RAGE (sRAGE) in healthy individuals and patients with type 2 diabetes (T2D) modulate vascular remodeling.
James N. Tsoporis, Erifili Hatziagelaki, Sahil Gupta, Shehla Izhar, Vasileos Salpeas, Anastasia Tsiavou, Angelos G. Rigopoulos, Andreas S. Triantafyllis, John C. Marshall, Thomas G. Parker, Ioannis K. Rizos   +10 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Reduced soluble receptor for advanced glycation end-products in COPD [PDF]

European Respiratory Journal, 2010
The soluble receptor for advanced glycation end-products (sRAGE) has anti-inflammatory properties, and deficiency of circulating sRAGE is associated with various human diseases. Whether sRAGE concentrations are reduced in chronic obstructive pulmonary disease (COPD) has not been determined.
Smith, D. J., Yerkovich, S. T., Towers, M. A., Carroll, M. L., Thomas, R., Upham, J. W.   +5 more
openaire   +5 more sources

Enhanced expression of receptor for advanced glycation end-products is associated with low circulating soluble isoforms of the receptor in Type 2 diabetes

, 2010
The sRAGE [soluble RAGE (receptor for advanced glycation end-products)] lack the transmembrane and cytoplasmic domain of the full-length receptor and can function as a decoy for RAGE ligands.
D. John Betteridge, Lin Leng, Richard Bucala, Tam, XHL, Bucala, R, Leng, L, Betteridge, DJ, Sammy W. M. Shiu, Kathryn C. B. Tan, Tan, KCB, Xystus H. L. Tam, Shiu, SWM   +11 more
core   +1 more source

Dietary Maillard reaction products: implications for human health and disease [PDF]

, 2009
When foods are heat processed, the sugars and lipids react with the proteins they contain via the Maillard and related reactions to form a wide range of products.
J. M. AMES, Ames, Jenny
core   +1 more source

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, EarlyView.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

Interaction of receptor for advanced glycation end products with advanced oxidation protein products induces podocyte injury [PDF]

, 2012
Chronic kidney disease (CKD) is characterized by progressive decline in renal function. Podocyte dropouts contribute to the pathogenesis of diabetic and nondiabetic CKD.
Yamamoto, Yasuhiko, Yamamoto, Hiroshi
core   +1 more source

Advanced Glycation End Products and Inflammation in Type 1 Diabetes Development

, 2022
Type 1 diabetes (T1D) is an autoimmune disease in which the β-cells of the pancreas are attacked by the host’s immune system, ultimately resulting in hyperglycemia. It is a complex multifactorial disease postulated to result from a combination
Rani O. Whiddett, Whiddett, Rani O., Fotheringham, Amelia K, Chenping Du, Whiddett, Rani O, Chen Chen, Josephine M. Forbes, Du, Chenping, Chen, Chen, Buckle, Irina, Forbes, Josephine M, Fotheringham, Amelia K., Forbes, Josephine M., Irina Buckle, Amelia K. Fotheringham   +14 more
core   +1 more source