Results 41 to 50 of about 82,871,848 (297)

Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes [PDF]

, 2012
Objective To determine the role of markers of plasma protein damage by glycation, oxidation and nitration in microalbuminuria onset or subsequent decline of glomerular filtration rate (termed “early GFR decline”) in patients with type 1 diabetes ...
Weston Andrew, Rabbani, N, Warram, James, Paul Thornalley, Perkins, BA, Naila Rabbani, Monika Niewczas, Thornalley, P, Thornalley, Paul J., Krolewski, AS, Rabbani, Naila, Adaikalakoteswari Antonysunil, Perkins Bruce A., Bruce A Perkins, Perkins, Bruce A., Weston, A, Thornalley Paul, Rabbani Naila, Krolewski, Andrzej S., Niewczas, M, Antonysunil Adaikalakoteswari, Adaikalakoteswari, A, Weston, Andrew J., Linda H Ficociello, Ficociello, LH, Ficociello Linda H., James Warram, Andrzej S Krolewski, Niewczas Monika, Warram, J, Andrew Weston, Antonysunil, Adaikalakoteswari, Warram James, Krolewski Andrzej S., Niewczas, Monika, Ficociello, Linda H.   +35 more
core   +1 more source

Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes [PDF]

, 2015
Background The receptor for advanced glycation end products (RAGE) is involved in the pathogenesis of diabetic complications, and soluble forms of the receptor (sRAGE) can counteract the detrimental action of the full-length receptor by acting as ...
Wong, Y, Lee, ACH, Betteridge, DJ, Tan, KCB, Lam, JKY, Shiu, SWM   +5 more
core   +1 more source

Elevated level of the soluble receptor for advanced glycation end-products involved in sarcopenia: an observational study

BMC Geriatrics, 2021
Background The soluble receptor for advanced glycation end products (sRAGE) has been proposed to serve as a marker for disease severity, but its role in sarcopenia, an age-related progressive loss of muscle mass and function, remains elusive.
Shou-En Wu, Yi-Lin Chiu, Tung-Wei Kao, Wei-Liang Chen   +3 more
doaj   +1 more source

Protein glycoxidation in neuropsychiatric disorders—from basic research to clinical practice

Redox Biology
This review integrates current findings on protein glycation, glycoxidation, and carbonyl stress in selected neurodegenerative and neuropsychiatric disorders, with a particular focus on mechanistic pathways relevant to Alzheimer's disease (AD), Parkinson'
Wiktor Orlof, Mateusz Maciejczyk
doaj   +1 more source

Plasma advanced glycation end products and soluble receptor for advanced glycation end products as indicators of sterol content in human carotid atherosclerotic plaques

Diabetes & Vascular Disease Research, 2022
Advanced glycation end products (AGEs) are independently related to cardiovascular disease (CVD) and favor cholesterol and oxysterol accumulation in macrophage foam cells.
Raphael S Pinto, Guilherme S Ferreira, Gina Camillo R Silvestre, Monique de Fátima M Santana, Valéria S Nunes, Lucas Ledesma, Paula R Pinto, Sayonara Ivana S de Assis, Ubiratan F Machado, Erasmo S da Silva, Marisa Passarelli   +10 more
doaj   +1 more source

RAGE is a critical factor of sex-based differences in age-induced kidney damage

Frontiers in Physiology, 2023
Introduction: Advanced glycation end products (AGEs) are a heterogeneous group of molecules with potential pathophysiological effects on the kidneys.
Seerat Bajwa, Alexander Luebbe, Ngoc Dong Nhi Vo, Eva-Maria Piskor, Christian Kosan, Gunter Wolf, Ivonne Loeffler   +6 more
doaj   +1 more source

Advanced glycation end products

, 2022
Advanced glycation end products (AGEs) are a heterogeneous group of compounds formed by non-enzymatic interactions between the carbonyl groups of reducing sugars and free amino groups of proteins, lipids, or nucleic acids.
Dat, Pham Thai
core  

Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice [PDF]

, 2014
The reactive dicarbonyls, glyoxal and methylglyoxal (MG), increase in diabetes and may participate in the development of diabetic complications. Glyoxal and MG are detoxified by the sequential activities of glyoxalase 1 (GLO1) and glyoxalase 2.
Rabbani, Naila, Brownlee, M., Geoffrion, M., Courville, K., Du, X., Irshad, Zehra, Vanderhyden, B. C., Ott-Braschi, S., Sui, G., Thornalley, Paul J., Milne, R. W., D'Agati, V. D.   +11 more
core   +1 more source

The impact of advanced glycation end products and their receptors on the development and prognosis of colorectal cancer

BMC Cancer
Purpose The purpose of this study was to analyze whether advanced glycation end products (AGEs) and their receptors had an impact on the development and prognosis of colorectal cancer (CRC).
Li-Juan Wang, Xiao-Yu Liu, Can Tan, Zi-wei Wang, Yong Cheng   +4 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source