The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy [PDF]
, 2014 The discovery of increased formation of methylglyoxal (MG) by cell metabolism in high glucose concentration in vitro suggested possible relevance to diabetes and diabetes complications (1,2).
Rabbani, Naila, Thornalley, Paul J.
core +1 more source
, 2022 This record contains raw data related to the article "Modulation of soluble receptor for advanced glycation end products isoforms and advanced glycation end products in long-living individuals" Background: Circulating levels of soluble receptor for ...
Raucci Angela
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Receptor for Advanced-Glycation End Products [PDF]
Circulation, 2006 Background— The beneficial effects of reperfusion therapies have been limited by the amount of ischemic damage that occurs before reperfusion. To enable development of interventions to reduce cell injury, our research has focused on understanding mechanisms involved in cardiac cell death after ...
Bucciarelli L +16 more
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Echinacoside-Zinc Nanomaterial Inhibits Skin Glycation by Suppressing the Transcriptional Activation of the Receptor for Advanced Glycation End-Products. [PDF]
ACS Nano, 2023 Glycation is a nonenzymatically catalyzed spontaneous reaction that eventually leads to the formation of advanced glycation end-products (AGEs), which can bind to the receptor for AGEs (RAGE).
Han J +8 more
europepmc +2 more sources
Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function [PDF]
, 2009 Background Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders.
Lednev, Igor K. +27 more
core +1 more source
Advanced glycation end products induce peroxisome proliferator-activated receptor γ down-regulation-related inflammatory signals in human chondrocytes via Toll-like receptor-4 and receptor for advanced glycation end products. [PDF]
PLoS ONE, 2013 Accumulation of advanced glycation end products (AGEs) in joints is important in the development of cartilage destruction and damage in age-related osteoarthritis (OA).
Ying Ju Chen +4 more
doaj +1 more source
Association between plasma sRAGE and emphysema according to the genotypes of AGER gene
BMC Pulmonary Medicine, 2022 Background Higher soluble receptor for advanced glycation end product (sRAGE) levels are considered to be associated with severe emphysema. However, the relationship remains uncertain when the advanced glycation end-product specific receptor (AGER) gene ...
Sooim Sin +4 more
doaj +1 more source
Advanced glycation end products regulate the receptor of AGEs epigenetically
Frontiers in Cell and Developmental Biology, 2023 Advanced glycation end-products (AGEs) can boost their receptor of AGE (RAGE) expression through the downstream signaling pathway to facilitate AGE–RAGE interaction. In this regulation process, the primary signaling pathways are NF-κB and STAT3. However, the inhibition of these transcription factors cannot completely block the upregulation of RAGE ...
Xiaoqing Wu +4 more
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Journal of Biological Research, 2018 The interaction of Advanced Glycation End products (AGEs) and their specific receptor, Receptor for Advanced Glycation End products (RAGE) play an important role in diabetes and vascular complications.
Claudia Borsa +4 more
doaj +1 more source
Biomedical and Biotechnology Research Journal, 2021 Background: Advanced glycation end products (AGE) are heterogeneous groups of molecules formed from the nonenzymatic reaction of reducing sugars with free amino groups of proteins, lipids, and nucleic acids.
Rajkumar Chandini +3 more
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