Results 31 to 40 of about 38,510 (295)

Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function [PDF]

, 2009
Background Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders.
Lednev, Igor K., Helmut Wittkowski, Anatoli Ianoul, Igor B Bronstein, Shekhtman, Alexander, Bjoerk, Per, Alexander Shekhtman, Per Bjoerk, Foell, Dirk, Wei He, Igor K Lednev, Olga V Moroz, He, Wei, Burkitt, William I., Xie, Jingjing, Derrick, Peter J., Bronstein, Igor B., Vera Novitskaya, Polyakova, Oxana, Ianoul, Anatoli, Dirk Foell, Will Burkitt, Oxana Polyakova, Moroz, Olga V., Peter J Derrick, Wittkowski, Helmut, Novitskaya, Vera, Jingjing Xie   +27 more
core   +1 more source

Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE) [PDF]

Journal of Clinical Investigation, 2001
Tubulointerstitial disease, a prominent phenomenon in diabetic nephropathy, correlates with decline in renal function. The underlying pathogenic link between chronic hyperglycemia and the development of tubulointerstitial injury has not been fully elucidated, but myofibroblast formation represents a key step in the development of tubulointerstitial ...
Oldfield, MD, Bach, LA, Forbes, JM, Nikolic-Paterson, D, McRobert, A, Thallas, V, Atkins, RC, Osicka, T, Jerums, G, Cooper, ME   +9 more
openaire   +5 more sources

Vitamin D and advanced glycation end products and their receptors

Pharmacological Research, 2020
Advanced glycation end products (AGEs) are destructive molecules in the body that, at high levels, contribute to the progression of various chronic diseases. Numerous studies have suggested a modifying effect of vitamin D on AGEs and their receptors. This study sought to summarize the effects of vitamin D on AGEs and their receptors, including receptor
Sorayya, Kheirouri, Mohammad, Alizadeh
openaire   +2 more sources

Receptor for Advanced-Glycation End Products [PDF]

Circulation, 2006
Background— The beneficial effects of reperfusion therapies have been limited by the amount of ischemic damage that occurs before reperfusion. To enable development of interventions to reduce cell injury, our research has focused on understanding mechanisms involved in cardiac cell death after ...
Bucciarelli L, Kaneko M, Ananthakrishnan R, Harja E, Lee LK, Hwang YC, Lerner S, Bakr S, Li Q, Lu Y, Song F, Qu W, Gomez T, Zou YS, Yan SF, Schmidt AM, Ramasamy R   +16 more
openaire   +2 more sources

Advanced glycation end products induce peroxisome proliferator-activated receptor γ down-regulation-related inflammatory signals in human chondrocytes via Toll-like receptor-4 and receptor for advanced glycation end products. [PDF]

PLoS ONE, 2013
Accumulation of advanced glycation end products (AGEs) in joints is important in the development of cartilage destruction and damage in age-related osteoarthritis (OA).
Ying Ju Chen, Meei Ling Sheu, Keh Sung Tsai, Rong Sen Yang, Shing Hwa Liu   +4 more
doaj   +1 more source

Association between plasma sRAGE and emphysema according to the genotypes of AGER gene

BMC Pulmonary Medicine, 2022
Background Higher soluble receptor for advanced glycation end product (sRAGE) levels are considered to be associated with severe emphysema. However, the relationship remains uncertain when the advanced glycation end-product specific receptor (AGER) gene ...
Sooim Sin, Myung-nam Lim, Jeeyoung Kim, So Hyeon Bak, Woo Jin Kim   +4 more
doaj   +1 more source

Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice [PDF]

, 2014
The reactive dicarbonyls, glyoxal and methylglyoxal (MG), increase in diabetes and may participate in the development of diabetic complications. Glyoxal and MG are detoxified by the sequential activities of glyoxalase 1 (GLO1) and glyoxalase 2.
Rabbani, Naila, Brownlee, M., Geoffrion, M., Courville, K., Du, X., Irshad, Zehra, Vanderhyden, B. C., Ott-Braschi, S., Sui, G., Thornalley, Paul J., Milne, R. W., D'Agati, V. D.   +11 more
core   +1 more source

Receptor of advanced glycation end products and cardiovascular risk in elderly with type 2 diabetes mellitus

Journal of Biological Research, 2018
The interaction of Advanced Glycation End products (AGEs) and their specific receptor, Receptor for Advanced Glycation End products (RAGE) play an important role in diabetes and vascular complications.
Claudia Borsa, Daniela Gradinaru, Denisa Margina, Gabriel Ioan Prada, Catalina Pena   +4 more
doaj   +1 more source

Plasma advanced glycation end products and soluble receptor for advanced glycation end products as indicators of sterol content in human carotid atherosclerotic plaques

Diabetes & Vascular Disease Research, 2022
Advanced glycation end products (AGEs) are independently related to cardiovascular disease (CVD) and favor cholesterol and oxysterol accumulation in macrophage foam cells.
Raphael S Pinto, Guilherme S Ferreira, Gina Camillo R Silvestre, Monique de Fátima M Santana, Valéria S Nunes, Lucas Ledesma, Paula R Pinto, Sayonara Ivana S de Assis, Ubiratan F Machado, Erasmo S da Silva, Marisa Passarelli   +10 more
doaj   +1 more source

Comparative evaluation of Salivary-Soluble Receptor for Advanced Glycation End Product (sRAGE) levels among betel chewers and chronic periodontitis patients

Biomedical and Biotechnology Research Journal, 2021
Background: Advanced glycation end products (AGE) are heterogeneous groups of molecules formed from the nonenzymatic reaction of reducing sugars with free amino groups of proteins, lipids, and nucleic acids.
Rajkumar Chandini, V Vasanthi, K Raghavendhar Karthik, Krishnan Rajkumar   +3 more
doaj   +1 more source