Results 71 to 80 of about 82,871,848 (297)

Advanced Glycation End-Products and Their Receptor-Mediated Roles: Inflammation and Oxidative Stress [PDF]

Iranian Journal of Medical Sciences, 2011
Glycation is a protein modification, which results in a change in a protein structure. Glycation is believed to be the etiology of various age-related diseases such as diabetes mellitus and Alzheimer’s disease (AD).
Parisa Younessi, Ali Younessi
doaj  

The immunobiology of the receptor of advanced glycation end-products: Trends and challenges

Immunobiology, 2013
Pattern-recognition receptors have been highly conserved in evolution. They recognize danger signals including both pathogen- and damage-associated molecular patterns, also known as alarmins. Several signaling pathways leading to an inflammatory reaction as part of an effective defensive response, are thus triggered.
Ileana, González, Jacqueline, Romero, Boris L, Rodríguez, Ramón, Pérez-Castro, Armando, Rojas   +4 more
openaire   +2 more sources

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Pyridoxamine ameliorates the effects of advanced glycation end products on subtotal nephrectomy induced chronic renal failure rats

, 2014
Advanced glycation end products (AGEs) contribute to the pathogenesis of renal diseases and have become a new therapeutic target for treatment. Chronic renal failure (CRF) is the end-stage of chronic renal diseases and highly associated with increased ...
Chuang, Yao-Chen;Wu, Ming-Shiou;Wu, Tai-Hsien;Su, Yi-Kai;Lee, Yi-Min, 吳明修   +1 more
core   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Polymorphism of the RAGE Affects the Serum Inflammatory Levels and Risk of Ischemic Stroke in a Chinese Population

Cellular Physiology and Biochemistry, 2013
Background: Increasing evidence shows that inflammation plays an important role in the occurrence and progression of acute ischemic stroke. The receptor for advanced glycation end products (RAGE) has been documented to involve in the pathogenic ...
XiaoPing Cui, HongJie Chen, Xuwei Hou, ShouSen Wang, Shoba Jayaram, ZhaoCong Zheng   +5 more
doaj   +1 more source

Advanced glycation end products and their receptor contribute to ovarian ageing [PDF]

Human Reproduction, 2013
Do advanced glycation end products (AGE) and the receptor for advanced glycation end products (RAGE) affect the cells of the human ovarian follicle?AGE accumulate on the surface of ovarian granulosa-lutein (GL) cells and monocytes by binding to RAGE and other receptors with possible functional effects on these cells.AGE and RAGE are expressed in ...
Mette Haug, Stensen, Tom, Tanbo, Ritsa, Storeng, Peter, Fedorcsak   +3 more
openaire   +2 more sources

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Higher levels of the soluble receptor for advanced glycation end products and lower levels of the extracellular newly identified receptor for advanced glycation end products were associated with lipid-lowering drugs in patients with type 1 diabetes: a comparative cross-sectional study

Lipids in Health and Disease, 2020
Background The receptors for advanced glycation end products (RAGE) are increased in atherosclerotic plaques. Soluble (s)RAGE decreases, whereas the extracellular newly identified receptor for advanced glycation end products (EN-RAGE) increases ...
Eva O. Melin, Jonatan Dereke, Magnus Hillman   +2 more
doaj   +1 more source

Arthroscopic Images Predict Tendon Integrity After Arthroscopic Rotator Cuff Repair Using a Deep Learning Model

Arthroscopy, EarlyView.
Purpose To assess the feasibility of a deep learning model for predicting early structural integrity after arthroscopic rotator cuff repair (ARCR) using intraoperative arthroscopic images obtained after the double‐row bridging repair technique. Methods This retrospective study included patients who underwent ARCR between January 2016 and June 2024 ...
Kuan‐Ting Wu, Angelo Mosca, Shun‐Wun Jhan, Shu‐Mei Guo, Jenn‐Jier James Lien, Johannes Barth   +5 more
wiley   +1 more source