Results 71 to 80 of about 59,203 (302)

Role of the receptor for advanced glycation end products inhepatic fbrosis

World Journal of Gastroenterology, 2009
To study the role of advanced glycation end products (AGE) and their specific receptor (RAGE) in the pathogenesis of liver fibrogenesis.In vitro RAGE expression and extracellular matrix-related gene expression in both rat and human hepatic stellate cells (HSC) were measured after stimulation with the two RAGE ligands, advanced glycation end product ...
Christina, Lohwasser, Daniel, Neureiter, Yury, Popov, Michael, Bauer, Detlef, Schuppan   +4 more
openaire   +2 more sources

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Higher levels of the soluble receptor for advanced glycation end products and lower levels of the extracellular newly identified receptor for advanced glycation end products were associated with lipid-lowering drugs in patients with type 1 diabetes: a comparative cross-sectional study

Lipids in Health and Disease, 2020
Background The receptors for advanced glycation end products (RAGE) are increased in atherosclerotic plaques. Soluble (s)RAGE decreases, whereas the extracellular newly identified receptor for advanced glycation end products (EN-RAGE) increases ...
Eva O. Melin, Jonatan Dereke, Magnus Hillman   +2 more
doaj   +1 more source

Association of SARS-CoV-2 nucleocapsid viral antigen and the receptor for advanced glycation end products with development of severe disease in patients presenting to the emergency department with COVID-19

Frontiers in Immunology, 2023
IntroductionThere remains a need to better identify patients at highest risk for developing severe Coronavirus Disease 2019 (COVID-19) as additional waves of the pandemic continue to impact hospital systems.
Zachary A. Matthay, Alexander T. Fields, Katherine D. Wick, Katherine D. Wick, Chayse Jones, Chayse Jones, H. Clifford Lane, Kimberly Herrera, Brenda Nuñez-Garcia, Efstathios Gennatas, Carolyn M. Hendrickson, Aaron E. Kornblith, Michael A. Matthay, Michael A. Matthay, Lucy Z. Kornblith, the COVID-19 Associated Coagulopathy Inflammation Thrombosis (Co-ACIT) Study Group, Biniam Ambachew, Roland J. Bainton, Sarah Cary, Lauren Chalwell, Christopher Colwell, Clayton Josephy, Philip Kurien, Deanna Lee, Matthieu LeGrand, Juan Carlos Montoy, Viet Nguyen, John J. Park, Arun Prakash, Brittany Robinson, Shelley India   +30 more
doaj   +1 more source

Transcriptional regulation of endothelin-1 expression by advanced glycation end-products in human aortic endothelium is mediated via NF-kappaΒ and AP-1 [PDF]

, 2012
Advanced Glycation End-products (AGEs) are produced by the non-enzymatic glycation of proteins, lipids and nucleic acids, resulting in an overload of highly reactive molecules of endogenous or exogenous (dietary) origin.
Adamopoulos, Christos, Dalagiorgou, Georgia, Diamanti-Kandarakis, Evanthia, Gargalionis, Antonios N., Kandaraki, Eleni A., Papavassiliou, Athanasios G., Piperi, Christina   +6 more
core  

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Advanced Glycation End-Products and Their Receptor-Mediated Roles: Inflammation and Oxidative Stress [PDF]

Iranian Journal of Medical Sciences, 2011
Glycation is a protein modification, which results in a change in a protein structure. Glycation is believed to be the etiology of various age-related diseases such as diabetes mellitus and Alzheimer’s disease (AD).
Parisa Younessi, Ali Younessi
doaj  

FPS-ZM1 Alleviates Circulating Indices of Liver Injury in Diet-Induced Type 2 Diabetic Mice

Acta Medica Iranica, 2022
Despite dietary/lifestyle modifications as well as glycemic and lipid control, non-alcoholic fatty liver disease (NAFLD) imposes a considerable risk to the patients by advancing to non-alcoholic steatohepatitis (NASH).
Somayeh Aslani, Saman Bahrambeigi, Davoud Sanajou   +2 more
doaj   +1 more source

AGEs in human lens capsule promote the TGFβ2-mediated EMT of lens epithelial cells:Implications for age-associated fibrosis [PDF]

, 2016
Proteins in basement membrane (BM) are long-lived and accumulate chemical modifications during aging; advanced glycation end-product (AGE) formation is one such modification. The human lens capsule is a BM secreted by lens epithelial cells. In this study,
Glomb, Marcus, Gupta, Pankaj, Howell, Scott, Nagaraj, Ram, Raghavan, Cibin, Singh, Annapurna, Smith, Andrew, Smith, Dawn, Smuda, Mareen, Wormstone, Ian   +9 more
core   +1 more source

Polymorphism of the RAGE Affects the Serum Inflammatory Levels and Risk of Ischemic Stroke in a Chinese Population

Cellular Physiology and Biochemistry, 2013
Background: Increasing evidence shows that inflammation plays an important role in the occurrence and progression of acute ischemic stroke. The receptor for advanced glycation end products (RAGE) has been documented to involve in the pathogenic ...
XiaoPing Cui, HongJie Chen, Xuwei Hou, ShouSen Wang, Shoba Jayaram, ZhaoCong Zheng   +5 more
doaj   +1 more source